Do proteomics analyses provide insights into reduced oxidative stress in the brain of an Alzheimer disease transgenic mouse model with an M631L amyloid precursor protein substitution and thereby the importance of amyloid-beta-resident methionine 35 in Alzheimer disease pathogenesis?

Antioxidants and Redox Signaling

Volumn 17, Issue 11, 2012, Pages 1507-1514

  Sultana, Rukhsana ^a,b   Robinson, Renã A S ^a,b   Bader Lange, Miranda ^a,b   Fiorini, Ada ^c   Galvan, Veronica ^d   Fombonne, Joanna ^d   Baker, Austin ^a,b   Gorostiza, Olivia ^d   Zhang, Junli ^d   Cai, Jian ^e   Pierce, William M ^e   Bredesen, Dale E ^d,f   Allan Butterfield, D ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^e UNIVERSITY OF LOUISVILLE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTIOXIDANT; METHIONINE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE MUTATION; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEOMICS; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GENE EXPRESSION REGULATION; HUMANS; LEUCINE; METHIONINE; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; OXIDATIVE STRESS; PROTEINS; PROTEOMICS;

MUS; MUS MUSCULUS;

EID: 84866857074     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2011.4470     Document Type: Article

References (9)

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