Cell responses to growth factors: The role of receptor tyrosine kinase intracellular domain fragments

Science Signaling

Volumn 5, Issue 243, 2012, Pages

  Carpenter, Graham ^a   Pozzi, Ambra ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CHAPERONE; EPIDERMAL GROWTH FACTOR RECEPTOR 4; ESTROGEN RECEPTOR BETA; GAMMA SECRETASE; GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; TYROSINE KINASE RECEPTOR; VASCULOTROPIN RECEPTOR 1;

BREAST TUMOR; CELL DEATH; CELL MIGRATION; CYTOPLASM; ENDOTHELIUM CELL; FETUS LUNG MATURATION; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; REVIEW; WNT SIGNALING PATHWAY;

CELL NUCLEUS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, BIOLOGICAL; PEPTIDE FRAGMENTS; RECEPTOR PROTEIN-TYROSINE KINASES; SECOND MESSENGER SYSTEMS;

EID: 84866845433     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2003526     Document Type: Review

References (38)

1. C. Y. Ni, M. P. Murphy, T. E. Golde, G. Carpenter, γ-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 294, 2179-2181 (2001).
2. G. Carpenter, H. J. Liao, Trafficking of receptor tyrosine kinases to the nucleus. Exp. Cell Res. 315, 1556-1566 (2009).
3. S. P. Sardi, J. Murtie, S. Koirala, B. A. Patten, G. Corfas, Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell 127, 185-197 (2006).
4. C. C. Williams, J. G. Allison, G. A. Vidal, M. E. Burow, B. S. Beckman, L. Marrero, F. E. Jones, The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone. J. Cell Biol. 167, 469-478 (2004).
5. I. Paatero, A. Jokilammi, P. T. Heikkinen, K. Iljin, O. P. Kallioniemi, F. E. Jones, P. M. Jaakkola, K. Elenius, Interaction with ErbB4 promotes hypoxia-inducible factor-1α signaling. J. Biol. Chem. 287, 9659-9671 (2012).
6. R. S. Muraoka-Cook, M. Sandahl, C. Husted, D. Hunter, L. Miraglia, S. M. Feng, K. Elenius, H. S. Earp, 3rd, The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells. Mol. Biol. Cell 17, 4118-4129 (2006).
7. M. Mazzone, L. M. Selfors, J. Albeck, M. Overholtzer, S. Sale, D. L. Carroll, D. Pandya, Y. Lu, G. B. Mills, J. C. Aster, S. Artavanis-Tsakonas, J. S. Brugge, Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 107, 5012-5017 (2010).
8. J. Han, J. Allalunis-Turner, M. J. Hendzel, Characterization and comparison of protein complexes initiated by the intracellular domain of individual Notch paralogs. Biochem. Biophys. Res. Commun. 407, 479-485 (2011).
9. J. Rokicki, P. M. Das, J. M. Giltnane, O. Wansbury, D. L. Rimm, B. A. Howard, F. E. Jones, The ERalpha coactivator, HER4/4ICD, regulates progesterone receptor expression in normal and malignant breast epithelium. Mol. Cancer 9, 150 (2010).
10. A. D. Thor, S. M. Edgerton, F. E. Jones, Subcellular localization of the HER4 intracellular domain, 4ICD, identifies distinct prognostic outcomes for breast cancer patients. Am. J. Pathol. 175, 1802-1809 (2009).
11. C. Lai, L. Feng, Implication of γ-secretase in neuregulin-induced maturation of oligodendrocytes. Biochem. Biophys. Res. Commun. 314, 535-542 (2004).
12. K. Hoeing, K. Zscheppang, S. Mujahid, S. Murray, M. V. Volpe, C. E. Dammann, H. C. Nielsen, Presenilin-1 processing of ErbB4 in fetal type II cells is necessary for control of fetal lung maturation. Biochim. Biophys. Acta 1813, 480-491 (2011).
13. K. Zscheppang, T. Dörk, A. Schmiedl, F. E. Jones, C. E. Dammann, Neuregulin receptor ErbB4 functions as a transcriptional cofactor for the expression of surfactant protein B in the fetal lung. Am. J. Respir. Cell Mol. Biol. 45, 761-767 (2011).
14. K. Zscheppang, M. Konrad, M. Zischka, V. Huhn, C. E. Dammann, Estrogen-induced upregulation of Sftpb requires transcriptional control of neuregulin receptor ErbB4 in mouse lung type II epithelial cells. Biochim. Biophys. Acta 1813, 1717-1727 (2011).
15. A. Naresh, W. Long, G. A. Vidal, W. C. Wimley, L. Marrero, C. I. Sartor, S. Tovey, T. G. Cooke, J. M. Bartlett, F. E. Jones, The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells. Cancer Res. 66, 6412-6420 (2006).
16. J. Lyu, V. Yamamoto, W. Lu, Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis. Dev. Cell 15, 773-780 (2008).
17. H. Peradziryi, N. A. Kaplan, M. Podleschny, X. Liu, P. Wehner, A. Borchers, N. S. Tolwinski, PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling. EMBO J. 30, 3729-3740 (2011).
18. H. W. Na, W. S. Shin, A. Ludwig, S. T. Lee, The cytosolic domain of protein-tyrosine kinase 7 (PTK7), generated from sequential cleavage by a disintegrin and metalloprotease 17 (ADAM17) and γ-secretase, enhances cell proliferation and migration in colon cancer cells. J. Biol. Chem. 287, 25001-25009 (2012).
19. J. Cai, W. G. Jiang, M. B. Grant, M. Boulton, Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1. J. Biol. Chem. 281, 3604-3613 (2006).
20. N. Rahimi, T. E. Golde, R. D. Meyer, Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1/FLT1 in leukemic cancer cells. Cancer Res. 69, 2607-2614 (2009).
21. J. Cai, Z. Chen, Q. Ruan, S. Han, L. Liu, X. Qi, S. L. Boye, W. W. Hauswirth, M. B. Grant, M. E. Boulton, γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1. J. Biol. Chem. 286, 42514-42523 (2011).
22. J. Cai, L. Wu, X. Qi, S. Li Calzi, S. Caballero, L. Shaw, Q. Ruan, M. B. Grant, M. E. Boulton, PEDF regulates vascular permeability by a γ-secretase-mediated pathway. PLoS ONE 6, e21164 (2011).
23. Z. Ablonczy, A. Prakasam, J. Fant, A. Fauq, C. Crosson, K. Sambamurti, Pigment epithelium-derived factor maintains retinal pigment epithelium function by inhibiting vascular endothelial growth factor-R2 signaling through γ-secretase. J. Biol. Chem. 284, 30177-30186 (2009).
24. Y. Y. Hu, M. H. Zheng, R. Zhang, Y. M. Liang, H. Han, Notch signaling pathway and cancer metastasis. Adv. Exp. Med. Biol. 727, 186-198 (2012).
25. K. G. Leong, K. Niessen, I. Kulic, A. Raouf, C. Eaves, I. Pollet, A. Karsan, Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J. Exp. Med. 204, 2935-2948 (2007).
26. X. Zhang, T. Chen, J. Zhang, Q. Mao, S. Li, W. Xiong, Y. Qiu, Q. Xie, J. Ge, Notch1 promotes glioma cell migration and invasion by stimulating β-catenin and NF-κB signaling via AKT activation. Cancer Sci. 103, 181-190 (2012).
27. A. M. Chioni, R. Grose, FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior. J. Cell Biol. 197, 801-817 (2012).
28. T. M. LaVallee, I. A. Prudovsky, G. A. McMahon, X. Hu, T. Maciag, Activation of the MAP kinase pathway by FGF-1 correlates with cell proliferation induction while activation of the Src pathway correlates with migration. J. Cell Biol. 141, 1647-1658 (1998).
29. F. Belleudi, C. Scrofani, M. R. Torrisi, P. Mancini, Polarized endocytosis of the keratinocyte growth factor receptor in migrating cells: role of SRC-signaling and cortactin. PLoS ONE 6, e29159 (2011).
30. C. L. Ewen, K. P. Kane, R. C. Bleackley, A quarter century of granzymes. Cell Death Differ. 19, 28-35 (2012).
31. C. R. Loeb, J. L. Harris, C. S. Craik, Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis. J. Biol. Chem. 281, 28326-28335 (2006).
32. K. Wilhelmsen, P. van der Geer, Phorbol 12-myristate 13-acetate-induced release of the colony-stimulating factor 1 receptor cytoplasmic domain into the cytosol involves two separate cleavage events. Mol. Cell. Biol. 24, 454-464 (2004).
33. G. Glenn, P. van der Geer, CSF-1 and TPA stimulate independent pathways leading to lysosomal degradation or regulated intramembrane proteolysis of the CSF-1 receptor. FEBS Lett. 581, 5377-5381 (2007).
34. C. Litterst, A. Georgakopoulos, J. Shioi, E. Ghersi, T. Wisniewski, R. Wang, A. Ludwig, N. K. Robakis, Ligand binding and calcium influx induce distinct ectodomain/γ-secretase-processing pathways of EphB2 receptor. J. Biol. Chem. 282, 16155-16163 (2007).
35. K. T. Lin, S. Sloniowski, D. W. Ethell, I. M. Ethell, Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion. J. Biol. Chem. 283, 28969-28979 (2008).
36. C. R. Degnin, M. B. Laederich, W. A. Horton, Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3. Mol. Biol. Cell 22, 3861-3873 (2011).
37. B. Foveau, F. Ancot, C. Leroy, A. Petrelli, K. Reiss, V. Vingtdeux, S. Giordano, V. Fafeur, D. Tulasne, Down-regulation of the met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis. Mol. Biol. Cell 20, 2495-2507 (2009).
38. M. B. Marron, H. Singh, T. A. Tahir, J. Kavumkal, H. Z. Kim, G. Y. Koh, N. P. Brindle, Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2. J. Biol. Chem. 282, 30509-30517 (2007).