Structural and mechanistic investigations on Salmonella typhimurium acetate kinase (AckA): Identification of a putative ligand binding pocket at the dimeric interface

BMC Structural Biology

Volumn 12, Issue , 2012, Pages

  Chittori, Sagar ^a,b   Savithri, Handanahal S ^a   Murthy, Mathur R N ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b DHHS   (United States)

Author keywords

Acetate and Sugar Kinases Heat shock cognate (Hsc) 70 Actin (ASKHA) superfamily; Acetate metabolism; AckA Pta pathway; Conformational rearrangement; Enzyme regulation

Indexed keywords

ACETATE KINASE; ACETIC ACID; ACETYL PHOSPHATE; ADENOSINE TRIPHOSPHATE; CITRIC ACID; COBALT; CYTIDINE TRIPHOSPHATE; FORMIC ACID; GUANOSINE TRIPHOSPHATE; MAGNESIUM ION; MANGANESE; METHANOSARCINA THERMOPHILA ACETATE KINASE; PHOSPHATE; PROPIONIC ACID; SALMONELLA TYPHIMURIUM ACETATE KINASE; UNCLASSIFIED DRUG; URIDINE TRIPHOSPHATE;

ARTICLE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ELECTRON; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME LOCALIZATION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; LIGAND BINDING; METHANOSARCINA THERMOPHILA; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DOMAIN; SALMONELLA TYPHIMURIUM; THERMOSTABILITY;

ACETATE KINASE; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; BIOCATALYSIS; CITRIC ACID; CRYSTALLOGRAPHY, X-RAY; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN MULTIMERIZATION; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; SALMONELLA TYPHIMURIUM; SEQUENCE ANALYSIS, PROTEIN; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI; METHANOSARCINA THERMOPHILA; SALMONELLA TYPHIMURIUM;

EID: 84866775525     PISSN: None     EISSN: 14726807     Source Type: Journal    
DOI: 10.1186/1472-6807-12-24     Document Type: Article

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