Biological evaluation of MR36, a novel non-polyglutamatable thymidylate synthase inhibitor that blocks cell cycle progression in melanoma cell lines

Investigational New Drugs

Volumn 30, Issue 4, 2012, Pages 1484-1492

  Giudice, Stefania ^a   Benassi, Luisa ^a   Bertazzoni, Giorgia ^a   Veratti, Eugenia ^a   Morini, Daria ^a   Azzoni, Paola ^a   Costi, Maria P ^a   Venturelli, Alberto ^a   Pirondi, Silvia ^a   Seidenari, Stefania ^a   Magnoni, Cristina ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Antifolates; Apoptosis; Chemotherapy; Melanoma cell lines; Thymidylate synthase

Indexed keywords

CASPASE 3; CYCLIN D1; FAS ANTIGEN; GENOMIC DNA; MESSENGER RNA; MR 36; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER RESEARCH; CELL CYCLE ARREST; CELL CYCLE REGULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INHIBITION; IN VITRO STUDY; INTRACELLULAR SIGNALING; MELANOMA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELL CYCLE; CELL LINE, TUMOR; COUMARINS; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MELANOMA; MODELS, BIOLOGICAL; PHOSPHORYLATION; POLYGLUTAMIC ACID; RETINOBLASTOMA PROTEIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; THYMIDYLATE SYNTHASE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84866743928     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-011-9733-2     Document Type: Article

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