A novel combination of methotrexate and epigallocatechin attenuates the overexpression of pro-inflammatory cartilage cytokines and modulates antioxidant status in adjuvant arthritic rats

Inflammation

Volumn 35, Issue 4, 2012, Pages 1435-1447

  Roy, Souvik ^a   Sannigrahi, Santanu ^a   Vaddepalli, Ram Prasad ^b   Ghosh, Balaram ^c   Pusp, Priyanka ^d  

^a NSHM Knowledge Campus ^*  (India)

^b ST PETER'S INSTITUTE OF PHARMACEUTICAL SCIENCES   (India)

^c MEDICAL COLLEGE AND HOSPITAL   (India)

^d Galaxy Concept Pvt Ltd   (India)

Author keywords

Adjuvant arthritis; Antioxidant; Cytokines; Epigallocatechin; Methotrexate

Indexed keywords

CATALASE; CYTOKINE; EPIGALLOCATECHIN; FREUND ADJUVANT; GLUTATHIONE; INTERLEUKIN 6; METHOTREXATE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ANTIOXIDANT STATUS; ARTICLE; CARTILAGE; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFECT; ENZYME ACTIVITY; HINDLIMB; HISTOPATHOLOGY; IMMUNOMODULATION; INFLAMMATION; LIPID PEROXIDATION; MALE; METABOLIC PARAMETERS; NONHUMAN; PAW EDEMA; PROTEIN EXPRESSION; RADIOGRAPHY; RAT; RHEUMATOID ARTHRITIS; TISSUE HOMOGENATE;

ANIMALS; ARTHRITIS, EXPERIMENTAL; CATALASE; CATECHIN; DISEASE PROGRESSION; DRUG COMBINATIONS; GLUTATHIONE; INTERLEUKIN-6; LIPID PEROXIDATION; MALE; METHOTREXATE; MYCOBACTERIUM; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 84866743565     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-012-9457-2     Document Type: Article

References (53)

1. Firestein, G.S. 2003. Evolving concept of rheumatoid arthritis. Nature 423: 356-361. doi:10.1038/nature01661. PMID: 12748655.
2. Mathew, A.J., J. Antony, S. Eremenco, B.V. Paul, B. Jayakumar, and J. Philip. 2009. Health-related quality of life in rheumatoid arthritis patients in South India. Singapore Medical Journal 50: 800-803. PMID: 19710980.
3. Wortmann, R.L. 1991. Pathogenesis of rheumatoid arthritis: Basis for future therapies. Seminars in Arthritis and Rheumatism 21 (suppl): 35-39. PMID: 1749947.
4. Zvaifler, N.J. 1988. New perspectives on the pathogenesis of rheumatoid arthritis. American Journal of Medicine 85(suppl): 12-17. PMID: 3052052.
5. Hassan, M.Q., R.A. Hadi, Z.S. Al-Rawi, V.A. Padron, and S.J. Stohs. 2001. The glutathione defense system in the pathogenesis of rheumatoid arthritis. Journal of Applied Toxicology 21: 69-73. doi:10.1002/jat.736. PMID: 11180282.
6. Heliovaara, M., P. Knekt, K. Aho, R.K. Aaran, G. Alfthan, and A. Aromaa. 1994. Serum antioxidants and risk of rheumatoid arthritis. Annals of the Rheumatic Diseases 53: 51-53. PMID: 8311556.
7. Jaswal, S., H.C. Mehta, A.K. Sood, and J. Kaur. 2003. Antioxidant status in rheumatoid arthritis and role of antioxidant therapy. Clinica Chimica Acta 338: 123-129. PMID: 14637276.
8. Feldmann, M., F.M. Brennan, and R.N. Maini. 1996. Role of cytokines in rheumatoid arthritis. Annual Review of Immunology 14: 397-440. doi:10.1146/annurev.immunol.14.1.397. PMID: 8717520.
9. Chu, C.Q., M. Field, M. Feldmann, and R.N. Maini. 1991. Localization of tumor necrosis factor alpha in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis. Arthritis and Rheumatism 34: 1125-1232. PMID: 1930331.
10. Farahat, M.M., G. Yanni, R. Poston, and G.S. Panayi. 1993. Cytokine expression in synovial membrane of patients with rheumatoid arthritis & osteoarthritis. Annals of the Rheumatic Diseases 52: 870-875. PMID: 8311538.
11. Nishimoto, N. 2006. Interleukin-6 in rheumatoid arthritis. Current Opinion in Rheumatology 18: 277-281. PMID: 16582692.
12. Akira, S., T. Taga, and T. Kishimoto. 1993. Interleukin-6 in biology and medicine. Advances in Immunology 54: 1-78. PMID: 8379461.
13. Kishimoto, T. 2005. IL-6: From laboratory to bedside. Clinical Reviews in Allergy & Immunology 28: 177-186. doi:10.1385/ CRIAI:28:3:177. PMID: 16129902.
14. Benslay, D.N., and A.M. Bendele. 1991. Development of a rapid screen for detecting and differentiating immunomodulatory vs antiinflammatory compounds in rats. Agents and Actions 34: 254-256. PMID: 1793040.
15. Halloran, M.M., J.M. Woods, Z. Szekanecz, N. Barquin, G.K. Haines, A. Walz, and A.E. Koch. 1999. The role of an epithelial neutrophil-Activating peptide-78-like protein in rat adjuvant-induced arthritis. Journal of Immunology 162: 7492-7500. PMID: 10358204.
16. Billiau, A., and P. Matthys. 2001. Modes of action of Freund's adjuvants in experimental models of autoimmune diseases. Journal of Leukocyte Biology 70: 849-860. PMID: 11739546.
17. Braun, J., and R. Rau. 2009. An update on methotrexate. Current Opinion in Rheumatology 21: 216-223. PMID: 19373092.
18. Cronstein, B.N. 2005. Low-dose methotrexate: A mainstay in the treatment of rheumatoid arthritis. Pharmacological Reviews 57: 163-172. doi:10.1124/pr.57.2.3. PMID: 15914465.
19. Joannides, A.J., H. El-Shaboury, R. Guirguis, J.J. Fasler, and V. Rajagopal. 2011. Methotrexate-Associated lymphoproliferative disorder presenting as disseminated malignancy. Rheumatology 50: 1927-1928. doi:10.1093/ rheumatology/ker214. PMID: 21719419.
20. MCkendry, R.J., and P. Dale. 1993. Adverse effects of low dose methotrexate therapy in rheumatoid arthritis. Journal of Rheumatology 20: 1850-1856. PMID: 8308769.
21. Smolen, J.S., D. Aletaha, J.W. Bijlsma, F.C. Breedveld, D. Boumpas, G. Burmester, B. Combe, M. Cutolo, M. de Wit, M. Dougados, P. Emery, A. Gibofsky, J.J. Gomez-Reino, B. Haraoui, J. Kalden, E.C. Keystone, T.K. Kvien, I. McInnes, E. Martin-Mola, C. Montecucco, M. Schoels, and D. van der Heijde. 2010. Treating rheumatoid arthritis to target: Recommendations of an international task force. Annals of the Rheumatic Diseases 69: 631-637. doi:10.1136/ard.2009.123919. PMID: 20215140.
22. Weinblatt, M.E., J.M. Kremer, A.D. Bankhurst, K.J. Bulpitt, R.M. Fleischmann, R.I. Fox, C.G. Jackson, M. Lange, and D.J. Burge. 1999. A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. The New England Journal of Medicine 340: 253-259. PMID: 9920948.
23. Trevisanato, S.I., and Y.I. Kim. 2000. Tea and health. Nutrition Reviews 58: 1-10. PMID: 10697388.
24. Yang, C.S., and Z.Y. Wang. 1993. Tea and cancer. Journal of the National Cancer Institute 85: 1038-1049. doi:10.1093/jnci/ 85.13.1038. PMID: 8515490.
25. Katiyar, S.K., and C.A. Elmets. 2001. Green tea polyphenolic antioxidants and skin photo protection. International Journal of Oncology 18: 1307-1313. PMID: 11351267.
26. Lin, Y.L., and J.K. Lin. 1997. Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by downregulating lipopolysaccharide-induced activity of transcription factor nuclear factorkappaB. Molecular Pharmacology 52: 465-472. PMID: 9281609.
27. Sachinidis, A., R.A. Skach, C. Seul, Y. Ko, J. Hescheler, H.Y. Ahn, and J. Fingerle. 2002. Inhibition of the PDGF beta-receptor tyrosine phosphorylation and its downstream intracellular signal transduction pathway in rat and human vascular smooth muscle cells by different catechins. The FASEB Journal 16: 893-895. PMID: 12039871.
28. Mukhtar, H., and N. Ahmad. 2000. Tea Polyphenols: Prevention of cancer and optimizing health. American Journal of Clinical Nutrition 71: 1698S-1702S. PMID: 10837321.
29. Constantin, A., P. Loubet-lescoulie, N. Lambert, and A. Cantagrel. 1998. Anti-inflammatory and immunoregulatory action of methotrexate in the treatment of rheumatoid arthritis: Evidence of increased interleukin-4 and interleukin-10 gene expression demonstrated in vitro by competitive reverse transcriptase-polymerase chain reaction. Arthritis and Rheumatism 41: 48-57. doi:10.1002/ 1529-0131(199801)41. PMID: 9433869.
30. Chesbrough, M., and J. McArthur. 1972. Laboratory manual of rural tropical hospitals. Churchil: The English Language Book Society. 31. David, G., and A.J. Sykes. 1951. Westergren and Wintrobe methods of estimating ESR compared. British Medical Journal 2: 1496-1497. PMID: 14886634.
31. Balasubramaniam, P., and A. Malathi. 1992. Comparative study of hemoglobin estimated by Drabkin's and Sahli's methods. Journal of Postgraduate Medicine 38: 8-9. PMID: 1512732.
32. Okhawa, H., N. Oishi, and K. Yagi. 1979. Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction. Analytical Biochemistry 95: 351-358. PMID: 36810.
33. Ellman, G.L. 1959. Tissue sulphydril groups. Archives of Biochemistry and Biophysics 82: 70-77. PMID: 13650640.
34. Kakkar, P., B. Das, and P.N. Viswanthan. 1984. A modified spectrophotometric assay of superoxide dismutase. Indian Journal of Biochemistry & Biophysics 21: 130-132. PMID: 6490072.
35. Narendhirakannan, R.T., S. Subramanian, and M. Kandaswamy. 2005. Free radical scavenging activity of Cleome gynandra L. leaves on adjuvant induced arthritis in rats. Molecular and Cellular Biochemistry 276: 71-80. doi:10.1007/s11010-005-3234-6. PMID: 16132687.
36. Hegen, M., J.C. Keith, M. Collins, and C.L. Nickerson-Nutter. 2008. Utility of animal models for identification of potential therapeutics for rheumatoid arthritis. Annals of the Rheumatic Diseases 67: 1505-1515. PMID: 18055474.
37. Bevaart, L., M.J. Vervoordeldonk, and P.P. Tak. 2010. Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis? Arthritis and Rheumatism 62: 2192-2205. doi:10.1002/art.27503. PMID: 20506322.
38. Quinones, M.P., S.K. Ahuja, F. Jimenez, J. Schaefer, E. Garavito, A. Rao, G. Chenaux, R.L. Reddick, W.A. Kuziel, and S.S. Ahuja. 2004. Experimental arthritis in CC chemokine receptor 2-null mice closely mimics severe human rheumatoid arthritis. The Journal ofClinical Investigation 113: 856-866. doi:10.1172/JCI20126. PMID: 15067318.
39. Altman, A., and F.J. Dixon. 1989. Immunomodifiers in vaccines. Advances in Veterinary Science and Comparative Medicine 33: 301-343. PMID: 2467538.
40. Crofford, L.J., H. Sano, K. Karalis, E.L. Webster, E.A. Goldmuntz, G.P. Chrousos, and R.L. Wilder. 1992. Local secretion of corticotrophin releasing hormone in the joints of Lewis rats with inflammatory arthritis. The Journal of Clinical Investigation 90: 2555-2564. doi:10.1172/JCI116150. PMID: 1281840.
41. Linblad, E.B. 2000. Freund's adjuvants. In Methods in molecular medicine: Vaccine adjuvants -preparation methods and research protocols, ed. D.T. O' Hagan, 49-63. Totowa: Humana Press.
42. Cannella, A.C., and J.R. O'Dell. 2003. Is there still a role for traditional disease modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis? Current Opinion in Rheumatology 15: 185-192. PMID: 12707569.
43. Swierkot, J., and J. Szechinski. 2006. Methotrexate in rheumatoid arthritis. Pharmacological Reports 58: 473-492. PMID: 16963793.
44. Rovensky, J., M. Stancikova, E. Rovenska, S. Stvrtina, V. Stvrtinova, and K. Svik. 2009. Treatment of rat adjuvant arthritis with flavonoid (Detralex), methotrexate, and their combination. Annals of the New York Academy of Sciences 1173: 798-804. doi:10.1111/j.1749-6632.2009.04618.x. PMID: 19758231.
45. Alastair, G., and M.B. Mowat. 1971. Hematological abnormalities in rheumatoid arthritis. Seminars in Arthritis and Rheumatism 1: 195-219. doi:10.1016/0049-0172(72)90001-7. PMID: 4343443.
46. Sotnikova, R., S. Ponist, J. Navarova, D. Mihalova, V. Tomekova, M. Strosova, and K. Bauerova. 2009. Effects of sesame oil in the model of adjuvant arthritis. Neuro Endocrinology Letters 30: 22-24. PMID: 20027138.
47. Ekambaram, S.P., S.S. Perumal, and V. Subramanian. 2011. Assessment of the in-vivo and in-vitro antioxidant potential of Strychnos potatorum Linn. seeds in Freund's adjuvant induced arthritic rats. Journal of Medicinal Plants Research 5: 4780-4787.
48. Karatas, F., I. Ozates, H. Canatan, I. Halifeoglu, M. Karatepe, and R. Colakt. 2003. Antioxidant status and lipid peroxidation in patients with rheumatoid arthritis. Indian Journal of Medical Research 118: 178-181. PMID:14700353.
49. Bauerová, K., S. Poništ, D. Mihalová, F. Dráfi, and V. Kuncírová. 2011. Utilization of adjuvant arthritis model for evaluation of new approaches in rheumatoid arthritis therapy focused on regulation of immune processes and oxidative stress. Interdisciplinary Toxicology 4: 33-39. doi:10.2478/v10102-011-0007-9. PMID: 21577282.
50. Cong, X. D., M. J. Ding, D. Z. Dai, Y. Wu, Y. Zhang, and Y. Dai. 2011. ER Stress, P66shc, and P-Akt/Akt mediate adjuvantinduced inflammation, which is blunted by argirein, a supermolecule and rhein in Rats. Inflammation PMID: 22095404. doi:10.1007/s10753-011-9407-4.
51. Guerne, P.A., B.L. Zuraw, J.H. Vaughan, D.A. Carson, and M. Lotz. 1989. Synovium as a source of interleukin 6 in vitro: Contribution to local and systemic manifestations of arthritis. The Journal of Clinical Investigation 83: 585-592. doi:10.1172/ JCI113921. PMID: 2464001.
52. Nietfeld, J.J., B. Wilbrink, M. Helle, J.L.A.M. Vanroy, R.W. Denotter, A.J.G. Swaak, and O. Huber-Bruning. 1990. Interleukin-1-induced interleukin-6 is required for the inhibition of proteoglycan synthesis by interleukin-1 in human articular cartilage. Arthritis and Rheumatism 33: 1695-1701. PMID: 2242066.
53. Deleuran, B.W., C.Q. Chu, M. Field, F.M. Brennan, P. Katsiki, M. Feldmann, and R.N. Maini. 1992. Localization of interleukin-1 a, type 1 interleukin-1 receptor and interleukin-1 receptor antagonist in the synovial membrane and cartilage/pannus junction in rheumatoid arthritis. British Journal of Rheumatology 31: 809-811. doi:10.1093/rheumatology/31.12.801. PMID: 1458286.