메뉴 건너뛰기




Volumn 245, Issue 8, 2012, Pages 453-463

The N-terminal half of the connexin protein contains the core elements of the pore and voltage gates

Author keywords

Channel pore; Chimera; Cysteine scanning; Hemichannels; Voltage gating connexin

Indexed keywords

CONNEXIN 46; CYSTEINE; GAP JUNCTION PROTEIN; REAGENT; THIOL;

EID: 84866742557     PISSN: 00222631     EISSN: 14321424     Source Type: Journal    
DOI: 10.1007/s00232-012-9457-z     Document Type: Article
Times cited : (37)

References (41)
  • 3
    • 0034957206 scopus 로고    scopus 로고
    • Gating properties of gap junction channels assembled from connexin43 and connexin43 fused with green fluorescent protein
    • Bukauskas FF, Bukauskiene A, Bennett MV, Verselis VK (2001) Gating properties of gap junction channels assembled from connexin43 and connexin43 fused with green fluorescent protein. Biophys J 81:137-152
    • (2001) Biophys J , vol.81 , pp. 137-152
    • Bukauskas, F.F.1    Bukauskiene, A.2    Bennett, M.V.3    Verselis, V.K.4
  • 4
    • 0036556336 scopus 로고    scopus 로고
    • Formation of the gap junction nexus: Binding partners for connexins
    • Duffy HS, Delmar M, Spray DC (2002) Formation of the gap junction nexus: binding partners for connexins. J Physiol Paris 96:243-249
    • (2002) J Physiol Paris , vol.96 , pp. 243-249
    • Duffy, H.S.1    Delmar, M.2    Spray, D.C.3
  • 5
    • 33745528139 scopus 로고    scopus 로고
    • The gap junction cellular internet: Connexin hemichannels enter the signalling limelight
    • Evans WH, De Vuyst E, Leybaert L (2006) The gap junction cellular internet: connexin hemichannels enter the signalling limelight. Biochem J 397:1-14
    • (2006) Biochem J , vol.397 , pp. 1-14
    • Evans, W.H.1    De Vuyst, E.2    Leybaert, L.3
  • 7
    • 0035704411 scopus 로고    scopus 로고
    • Emerging issues of connexin channels: Biophysics fills the gap
    • Harris AL (2001) Emerging issues of connexin channels: biophysics fills the gap. Q Rev Biophys 34:325-472
    • (2001) Q Rev Biophys , vol.34 , pp. 325-472
    • Harris, A.L.1
  • 8
    • 0019350755 scopus 로고
    • Kinetic properties of a voltage-dependent junctional conductance
    • Harris AL, Spray DC, Bennett MV (1981) Kinetic properties of a voltage-dependent junctional conductance. J Gen Physiol 77:95-117
    • (1981) J Gen Physiol , vol.77 , pp. 95-117
    • Harris, A.L.1    Spray, D.C.2    Bennett, M.V.3
  • 9
    • 33646137561 scopus 로고    scopus 로고
    • Conductance of connexin hemichannels segregates with the first transmembrane segment
    • Hu X, Ma M, Dahl G (2006) Conductance of connexin hemichannels segregates with the first transmembrane segment. Biophys J 90:140-150
    • (2006) Biophys J , vol.90 , pp. 140-150
    • Hu, X.1    Ma, M.2    Dahl, G.3
  • 11
    • 0032321487 scopus 로고    scopus 로고
    • Substituted-cysteine accessibility method
    • Karlin A, Akabas MH (1998) Substituted-cysteine accessibility method. Methods Enzymol 293:123-145
    • (1998) Methods Enzymol , vol.293 , pp. 123-145
    • Karlin, A.1    Akabas, M.H.2
  • 13
    • 0141919839 scopus 로고    scopus 로고
    • Single-channel SCAM identifies pore-lining residues in the first extracellular loop and first transmembrane domains of cx46 hemichannels
    • Kronengold J, Trexler EB, Bukauskas FF, Bargiello TA, Verselis VK (2003b) Single-channel SCAM identifies pore-lining residues in the first extracellular loop and first transmembrane domains of Cx46 hemichannels. J Gen Physiol 122:389-405
    • (2003) J Gen Physiol , vol.122 , pp. 389-405
    • Kronengold, J.1    Trexler, E.B.2    Bukauskas, F.F.3    Bargiello, T.A.4    Verselis, V.K.5
  • 14
    • 80555135976 scopus 로고    scopus 로고
    • Molecular dynamics simulations of the cx26 hemichannel: Evaluation of structural models with brownian dynamics
    • Kwon T, Harris AL, Rossi A, Bargiello TA (2011) Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics. J Gen Physiol 138: 475-493
    • (2011) J Gen Physiol , vol.138 , pp. 475-493
    • Kwon, T.1    Harris, A.L.2    Rossi, A.3    Bargiello, T.A.4
  • 15
    • 63149198803 scopus 로고    scopus 로고
    • Connexin mutations causing skin disease and deafness increase hemichannel activity and cell death when expressed in xenopus oocytes
    • Lee JR, Derosa AM, White TW (2009) Connexin mutations causing skin disease and deafness increase hemichannel activity and cell death when expressed in Xenopus oocytes. J Invest Dermatol 129:870-878
    • (2009) J Invest Dermatol , vol.129 , pp. 870-878
    • Lee, J.R.1    Derosa, A.M.2    White, T.W.3
  • 16
    • 73149098341 scopus 로고    scopus 로고
    • Post-translational modifications of connexin26 revealed by mass spectrometry
    • Locke D, Bian S, Li H, Harris AL (2009) Post-translational modifications of connexin26 revealed by mass spectrometry. Biochem J 424:385-398
    • (2009) Biochem J , vol.424 , pp. 385-398
    • Locke, D.1    Bian, S.2    Li, H.3    Harris, A.L.4
  • 20
    • 43749106037 scopus 로고    scopus 로고
    • Charges dispersed over the permeation pathway determine the charge selectivity and conductance of a cx32 chimeric hemichannel
    • Oh S, Verselis VK, Bargiello TA (2008) Charges dispersed over the permeation pathway determine the charge selectivity and conductance of a Cx32 chimeric hemichannel. J Physiol 586: 2445-2461
    • (2008) J Physiol , vol.586 , pp. 2445-2461
    • Oh, S.1    Verselis, V.K.2    Bargiello, T.A.3
  • 21
    • 0033745976 scopus 로고    scopus 로고
    • Reversal of the gating polarity of gap junctions by negative charge substitutions in the N-terminus of connexin 32
    • Purnick PE, Oh S, Abrams CK, Verselis VK, Bargiello TA (2000) Reversal of the gating polarity of gap junctions by negative charge substitutions in the N-terminus of connexin 32. Biophys J 79:2403-2415
    • (2000) Biophys J , vol.79 , pp. 2403-2415
    • Purnick, P.E.1    Oh, S.2    Abrams, C.K.3    Verselis, V.K.4    Bargiello, T.A.5
  • 22
    • 0033063884 scopus 로고    scopus 로고
    • The role of a conserved proline residue in mediating conformational changes associated with voltage gating of cx32 gap junctions
    • Ri Y, Ballesteros JA, Abrams CK, Oh S, Verselis VK, Weinstein H, Bargiello TA (1999) The role of a conserved proline residue in mediating conformational changes associated with voltage gating of Cx32 gap junctions. Biophys J 76:2887-2898
    • (1999) Biophys J , vol.76 , pp. 2887-2898
    • Ri, Y.1    Ballesteros, J.A.2    Abrams, C.K.3    Oh, S.4    Verselis, V.K.5    Weinstein, H.6    Bargiello, T.A.7
  • 23
    • 77954320871 scopus 로고    scopus 로고
    • 2+ permeability in cx26 hemichannels formed by the A40 V and G45E mutations that cause keratitis ichthyosis deafness syndrome
    • 2+ permeability in Cx26 hemichannels formed by the A40 V and G45E mutations that cause keratitis ichthyosis deafness syndrome. J Gen Physiol 136:47-62
    • (2010) J Gen Physiol , vol.136 , pp. 47-62
    • Sanchez, H.A.1    Mese, G.2    Srinivas, M.3    White, T.W.4    Verselis, V.K.5
  • 25
    • 0019365945 scopus 로고
    • Equilibrium properties of a voltage-dependent junctional conductance
    • Spray DC, Harris AL, Bennett MV (1981) Equilibrium properties of a voltage-dependent junctional conductance. J Gen Physiol 77: 77-93
    • (1981) J Gen Physiol , vol.77 , pp. 77-93
    • Spray, D.C.1    Harris, A.L.2    Bennett, M.V.3
  • 26
    • 0033564511 scopus 로고    scopus 로고
    • Voltage dependence of macroscopic and unitary currents of gap junction channels formed by mouse connexin50 expressed in rat neuroblastoma cells
    • Srinivas M, Costa M, Gao Y, Fort A, Fishman GI, Spray DC (1999) Voltage dependence of macroscopic and unitary currents of gap junction channels formed by mouse connexin50 expressed in rat neuroblastoma cells. J Physiol (Lond) 517:673-689
    • (1999) J Physiol (Lond) , vol.517 , pp. 673-689
    • Srinivas, M.1    Costa, M.2    Gao, Y.3    Fort, A.4    Fishman, G.I.5    Spray, D.C.6
  • 27
    • 20444397467 scopus 로고    scopus 로고
    • Correlative studies of gating in cx46 and cx50 hemi-channels and gap junction channels
    • Srinivas M, Kronengold J, Bukauskas FF, Bargiello TA, Verselis VK (2005) Correlative studies of gating in Cx46 and Cx50 hemi-channels and gap junction channels. Biophys J 88:1725-1739
    • (2005) Biophys J , vol.88 , pp. 1725-1739
    • Srinivas, M.1    Kronengold, J.2    Bukauskas, F.F.3    Bargiello, T.A.4    Verselis, V.K.5
  • 28
    • 33748464388 scopus 로고    scopus 로고
    • Structural determinants for the differences in voltage gating of chicken cx56 and cx45.6 gap-junctional hemichannels
    • Tong JJ, Ebihara L (2006) Structural determinants for the differences in voltage gating of chicken Cx56 and Cx45.6 gap-junctional hemichannels. Biophys J 91:2142-2154
    • (2006) Biophys J , vol.91 , pp. 2142-2154
    • Tong, J.J.1    Ebihara, L.2
  • 29
    • 16644385797 scopus 로고    scopus 로고
    • Exchange of gating properties between rat cx46 and chicken cx45.6
    • Tong JJ, Liu X, Dong L, Ebihara L (2004) Exchange of gating properties between rat cx46 and chicken cx45.6. Biophys J 87:2397-2406
    • (2004) Biophys J , vol.87 , pp. 2397-2406
    • Tong, J.J.1    Liu, X.2    Dong, L.3    Ebihara, L.4
  • 31
    • 0033636361 scopus 로고    scopus 로고
    • The first extracellular loop domain is a major determinant of charge selectivity in connexin46 channels
    • Trexler EB, Bukauskas FF, Kronengold J, Bargiello TA, Verselis VK (2000) The first extracellular loop domain is a major determinant of charge selectivity in connexin46 channels. Biophys J 79: 3036-3051
    • (2000) Biophys J , vol.79 , pp. 3036-3051
    • Trexler, E.B.1    Bukauskas, F.F.2    Kronengold, J.3    Bargiello, T.A.4    Verselis, V.K.5
  • 34
    • 66749104885 scopus 로고    scopus 로고
    • The connexin channel pore: Pore-lining segments and residues
    • Harris AL, Locke D (eds) Humana Press, New York
    • Verselis VK (2009) The connexin channel pore: pore-lining segments and residues. In: Harris AL, Locke D (eds) Connexins: a guide. Humana Press, New York, pp 77-102
    • (2009) Connexins: A Guide , pp. 77-102
    • Verselis, V.K.1
  • 35
    • 35448996973 scopus 로고    scopus 로고
    • Gap junction channels permeability and voltage gating advances in molecular and cell biology
    • Hertzberg EL (ed) Elsevier, Stamford
    • Verselis VK, Veenstra R (2000) Gap junction channels permeability and voltage gating advances in molecular and cell biology. In: Hertzberg EL (ed) Gap junctions. Elsevier, Stamford, pp 129-192
    • (2000) Gap Junctions , pp. 129-192
    • Verselis, V.K.1    Veenstra, R.2
  • 36
    • 0028299152 scopus 로고
    • Opposite voltage gating polarities of two closely related connexins
    • Verselis VK, Ginter CS, Bargiello TA (1994) Opposite voltage gating polarities of two closely related connexins. Nature 368:348-351
    • (1994) Nature , vol.368 , pp. 348-351
    • Verselis, V.K.1    Ginter, C.S.2    Bargiello, T.A.3
  • 37
    • 63249084923 scopus 로고    scopus 로고
    • Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domain
    • Verselis VK, Trelles MP, Rubinos C, Bargiello TA, Srinivas M (2009) Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domain. J Biol Chem 284:4484-4493
    • (2009) J Biol Chem , vol.284 , pp. 4484-4493
    • Verselis, V.K.1    Trelles, M.P.2    Rubinos, C.3    Bargiello, T.A.4    Srinivas, M.5
  • 38
    • 1942485065 scopus 로고    scopus 로고
    • The permeability of gap junction channels to probes of different size is dependent on connexin composition and permeant-pore affinities
    • Weber PA, Chang HC, Spaeth KE, Nitsche JM, Nicholson BJ (2004) The permeability of gap junction channels to probes of different size is dependent on connexin composition and permeant-pore affinities. Biophys J 87:958-973
    • (2004) Biophys J , vol.87 , pp. 958-973
    • Weber, P.A.1    Chang, H.C.2    Spaeth, K.E.3    Nitsche, J.M.4    Nicholson, B.J.5
  • 39
    • 0027070644 scopus 로고
    • Mouse cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70
    • White TW, Bruzzone R, Goodenough DA, Paul DL (1992) Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70. Mol Biol Cell 3:711-720
    • (1992) Mol Biol Cell , vol.3 , pp. 711-720
    • White, T.W.1    Bruzzone, R.2    Goodenough, D.A.3    Paul, D.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.