Inhibition of Na V1.6 sodium channel currents by a novel series of 1,4-disubstituted-triazole derivatives obtained via copper-catalyzed click chemistry

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 20, 2012, Pages 6401-6404

  Rivara, Mirko ^a   Patel, Manoj K ^b   Amori, Laura ^a   Zuliani, Valentina ^a  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

1,4 Triazoles; Click chemistry; Patch clamp electrophysiology; rNa V1.6; Sodium channels

Indexed keywords

1,4 TRIAZOLE DERIVATIVE; ALKYNE; ANTICONVULSIVE AGENT; AZIDE; COPPER; HETEROCYCLIC COMPOUND; SODIUM CHANNEL BLOCKING AGENT; SODIUM CHANNEL NAV1.6; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL; SCN8A PROTEIN, RAT; VOLTAGE GATED SODIUM CHANNEL BLOCKING AGENT;

ANTICONVULSANT ACTIVITY; ARTICLE; CATALYST; CHANNEL GATING; CLICK CHEMISTRY; CONFORMATIONAL TRANSITION; CYCLOADDITION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EPILEPSY; IC 50; NONHUMAN; RAT; SODIUM CURRENT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ANIMAL; CATALYSIS; CELL STRAIN HEK293; CHEMISTRY; HUMAN; METABOLISM; SYNTHESIS;

RATTUS;

ANIMALS; CATALYSIS; CLICK CHEMISTRY; COPPER; HEK293 CELLS; HUMANS; NAV1.6 VOLTAGE-GATED SODIUM CHANNEL; RATS; TRIAZOLES; VOLTAGE-GATED SODIUM CHANNEL BLOCKERS;

EID: 84866735406     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.067     Document Type: Article

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