Novel AI-2 quorum sensing inhibitors in Vibrio harveyi identified through structure-based virtual screening

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 20, 2012, Pages 6413-6417

  Zhu, Peng ^a   Peng, Hanjing ^b   Ni, Nanting ^b   Wang, Binghe ^b   Li, Minyong ^a  

^a SHANDONG UNIVERSITY   (China)

^b GEORGIA STATE UNIVERSITY   (United States)

Author keywords

AI 2; LuxPQ; Quorum sensing inhibitors; Vibrio harveyi; Virtual screening

Indexed keywords

ANTIINFECTIVE AGENT;

ANTIBACTERIAL ACTIVITY; ARTICLE; COMPUTER MODEL; COMPUTER PROGRAM; CRYSTAL STRUCTURE; CYTOPATHOGENIC EFFECT; DRUG IDENTIFICATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; IC 50; MOLECULAR DOCKING; NONHUMAN; QUORUM SENSING; VIBRIO HARVEYI; VIRTUAL REALITY;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; MOLECULAR DOCKING SIMULATION; PHOSPHOTRANSFERASES; PROTEIN CONFORMATION; QUORUM SENSING; TRANSCRIPTION FACTORS; VIBRIO; VIBRIO INFECTIONS;

VIBRIO HARVEYI;

EID: 84866735024     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.062     Document Type: Article

References (25)

1. J.A. Smith, J. Wang, S.M. Nguyen-Mau, V. Lee, and H.O. Sintim Chem. Commun. 2009 7033
2. L. Hall-Stoodley, and P. Stoodley Trends Microbiol. 13 2005 7
3. H. Matsusaki, N. Chinachoti, K. Sonomoto, and A. Ishizaki Ann. N.Y. Acad. Sci. 864 1998 422
4. P.V. Dunlap J. Mol. Microbiol. Biotechnol. 1 1999 5
5. A. Camilli, and B.L. Bassler Science 311 2006 1113
6. A. Eberhard, A.L. Burlingame, C. Eberhard, G.L. Kenyon, K.H. Nealson, and N.J. Oppenheimer Biochemistry (Mosc.) 20 1981 2444
7. B.L. Bassler, M. Wright, and M.R. Silverman Mol. Microbiol. 13 1994 273
8. V. Sperandio, A.G. Torres, B. Jarvis, J.P. Nataro, and J.B. Kaper Proc. Natl. Acad. Sci. U.S.A. 100 2003 8951
9. J.M. Henke, and B.L. Bassler J. Bacteriol. 186 2004 6902
10. E.C. Pesci, J.B. Milbank, J.P. Pearson, S. McKnight, A.S. Kende, E.P. Greenberg, and B.H. Iglewski Proc. Natl. Acad. Sci. U.S.A. 96 1999 11229
11. G.J. Lyon, J.S. Wright, A. Christopoulos, R.P. Novick, and T.W. Muir J. Biol. Chem. 277 2002 6247
12. C.A. Lowery, T.J. Dickerson, and K.D. Janda Chem. Soc. Rev. 37 2008 1337
13. N.C. Reading, and V. Sperandio FEMS Microbiol. Lett. 254 2006 1
14. M.B. Neiditch, M.J. Federle, A.J. Pompeani, R.C. Kelly, D.L. Swem, P.D. Jeffrey, B.L. Bassler, and F.M. Hughson Cell 126 2006 1095
15. P. Zhu, and M. Li Curr. Med. Chem. 19 2012 174
16. M. Li, N. Ni, H.T. Chou, C.D. Lu, P.C. Tai, and B. Wang ChemMedChem 3 2008 1242
17. H. Peng, Y. Cheng, N. Ni, M. Li, G. Choudhary, H.T. Chou, C.D. Lu, P.C. Tai, and B. Wang ChemMedChem 4 2009 1457
18. A.M. Stock Nat. Struct. Mol. Biol. 13 2006 861
19. G. Brackman, S. Celen, K. Baruah, P. Bossier, S. Van Calenbergh, H.J. Nelis, and T. Coenye Microbiology (Reading, England) 155 2009 4114
20. J.C. Baber, W.A. Shirley, Y. Gao, and M. Feher J. Chem. Inf. Model. 46 2005 277
21. N. Ni, H.-T. Chou, J. Wang, M. Li, C.-D. Lu, P.C. Tai, and B. Wang Biochem. Biophy. Res. Commun. 369 2008 590
22. R. Vilchez, A. Lemme, V. Thiel, S. Schulz, H. Sztajer, and I. Wagner-Döbler Anal. Bioanal. Chem. 387 2007 489
23. J. Wu, J. Wang, M. Li, Y. Yang, B. Wang, and Y.G. Zheng Bioorg. Chem. 39 2011 53
24. Q. Yang, D. Fedida, H. Xu, B. Wang, L. Du, X. Wang, M. Li, and Q. You ChemMedChem 5 2010 1353
25. M. Li, Y.J. Huang, P.C. Tai, and B. Wang Biochem. Biophys. Res. Commun. 368 2008 839