Compound instability in dimethyl sulphoxide, case studies with 5-aminopyrimidines and the implications for compound storage and screening

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 20, 2012, Pages 6405-6409

  Procházková, Eliška ^a   Jansa, Petr ^a   Březinová, Anna ^a   Čechová, Lucie ^a   Mertlíková Kaiserová, Helena ^a   Holý, Antonín ^a   Dračínský, Martin ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

5 Aminopyrimidines; Dimethyl sulphoxide; Oxidation; Pyrimidopteridines; Self condensation

Indexed keywords

5 AMINOPYRIMIDINE DERIVATIVE; ALLOXAN; ANTIOXIDANT; DIMETHYL SULFOXIDE; PTERIDINE; PYRIMIDINE DERIVATIVE; SOLVENT; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL REACTION; DRUG STABILITY; DRUG STORAGE; DRUG STRUCTURE; IN VITRO STUDY; OXIDATION; POLYMERIZATION; REACTION ANALYSIS;

AMINOPYRIDINES; DIMETHYL SULFOXIDE; OXIDANTS; OXIDATION-REDUCTION; SOLVENTS;

EID: 84866735022     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.065     Document Type: Article

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