Hypoxia-induced lipid peroxidation in rat brain and protective effect of carnitine and phosphocreatine

Neurochemical Research

Volumn 27, Issue 9, 2002, Pages 899-904

  Rauchová, Hana ^a,b   Koudelová, Jitka ^c   Drahota, Zdeněk ^a   Mourek, Jindřich ^c  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^b CZECH TECHNICAL UNIVERSITY IN PRAGUE   (Czech Republic)

^c CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Brain (rat); Carnitine; Hypobaric hypoxia; Lactate pyruvate ratio; Lipid peroxidation; Phosphocreatine

Indexed keywords

ALPHA TOCOPHEROL; CARNITINE; CREATINE PHOSPHATE; LACTIC ACID; LIPID; PYRUVIC ACID; SCAVENGER; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DISEASE MARKER; HYPOBARISM; HYPOXIA; LACTATE BLOOD LEVEL; LIPID PEROXIDATION; METABOLISM; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANOXIA; BRAIN; CARNITINE; FEMALE; LIPID PEROXIDATION; MALE; PHOSPHOCREATINE; RATS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

ANIMALIA;

EID: 0036746892     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020339530924     Document Type: Article

References (34)

1. Halliwell, B. 1992. Reactive oxygen species and the central nervous system. J. Neurochem. 59:1609-1623.
2. Braughler, M. J. and Hall, E. D. 1989. Central nervous system trauma and stroke. I. Biochemical considerations for oxygen radical formation and lipid peroxidation. Free Radic. Biol. Med. 6:303-313.
3. Gutteridge, J. M. C. 1995. Oxidative stress in neurobiology: An important role for iron. Pages 287-302, in Cutler, R. G., Packer, L., Bertram, J., and Mon, A. (eds.), Stress and Aging, Birkhauser Verlag, Basel.
4. Groenendaal, F., Mishra, O. P., McGowan, J. E., Hoffman, D. J., and Delivoria-Papadopoulos, M. 1996. Cytosolic and membrane-bound cerebral nitric oxide synthase activity during hypoxia in cortical tissue of newborn piglets. Neurosci. Lett. 15:121-124.
5. Kaplán, P., Doval, M., Majerová, Z., Lehotský, J., and Račay, P. 2000. Iron-induced lipid peroxidation and protein modification in endoplasmic reticulum membranes: Protection by stobadine. Int. J. Biochem. Cell Biol. 32:539-547.
6. +-ATPase activity. Physiol. Res. 48:73-78.
7. Ferrarri, R., DiMauro, S., and Sherwood, G. (eds.) 1992. L-Carnitine and its role in medicine: From function to therapy. Page 433. Academic Press, Harcourt Brace Jovanovich Publishers, London.
8. Broderick, T. L., Quinney, H. A., Barker, C. C., and Lopaschuk, G. D. 1993. Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation. Circulation 87:972-981.
9. Calvani, M. and Arrigoni-Martelli, E. 1999. Attenuation by acetyl-L-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion. Int. J. Tissue React. 21:1-6.
10. Loster, H. and Punzel, M. 1998. Effects of L-carnitine on mechanical recovery of isolated rat hearts in relation to the reperfusion with glucose and palmitate. Mol. Cell Biochem. 185:65-75.
11. Opie, L. H. 1987. Role of carnitine in fatty acid metabolism of normal and ischemic myocardium. Am. Heart J. 97:375-388.
12. Reznick, A. Z., Kagan, V. E., Ramsey, R., Tsuchiya, M., Khwaja, S., Serbinova, E. A., and Packer, L. 1992. Antiradical effects in L-propionyl carnitine protection of the heart against ischemia-reperfusion injury: The possible role of iron chelation. Arch. Biochem. Biophys. 296:394-401.
13. Luo, X., Reichetzer, B., Trines, J., Benson, L. N., and Lehotay, D. C. 1999. L-Carnitine attenuates doxorubicin-induced lipid peroxidation in rats. Free Radic. Biol. Med. 26:1158-1165.
14. Packer, L., Valenza, E., Serbinova, P., Starke-Reed, P., Frost, K., and Kagan V. 1991. Free radical scavenging is involved in the protective effect of L-propionyl-carnitine against ischemiareperfusion injury of the heart. Arch. Biochem. Biophys. 288:533-537.
15. Koudelová, J., Mourek, J., Drahota, Z., and Rauchová, H. 1994. Protective effect of carnitine on lipoperoxide formation in rat brain. Physiol. Res. 43:387-389.
16. Marešová, D., Rauchová, H., Jandová, K., Valkounová, I., Koudelová, J., and Trojan, S. 2001. Carnitine pretreatment can partially change the excitability in the immature nervous tissue. Physiol. Res. 50:439-442.
17. Burton, G. W., Cheeseman, K. H., Doba, T., Ingold, K. U., and Slater, T. F. 1983. Vitamin E as an antioxidant in vitro and in vivo. Pages 4-18, in Biology of Vitamin E, Ciba Foundation Symposium 101, Pitman Press, London.
18. Koudelová, J., Rauchová, H., Šlapetová, V., Mourek, J., and Drahota, Z. 1999. Hypoxia-induced lipid peroxidation in rat brain: Protective effect of carnitine and phosphocreatine. Physiol. Res. 48(suppl. 1):S111.
19. Trojan, S. 1993. Protective effect of vitamin E on brain ischaemia during ontogenesis. Physiol. Res. 42:53-54.
20. Ohkawa, H., Ohishi, N., and Yagi, K. 1979. Assay of lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal. Biochem. 95:351-358.
21. Koudelová, J. and Mourek, J. 1992. Different degrees of lipid peroxidation in the CNS of young and adult rats exposed to short-term hypobaric hypoxia. Physiol. Res. 41:207-212.
22. Moore, S. A. 2001. Polyunsaturated fatty acid synthesis and release by brain-derived cells in vitro. J. Mol. Neurosci. 16:195-200.
23. Blázquez, C., Woods, A., De Ceballos, M. L., Carling, D., and Guzmán, M. 1999. The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes. J. Neurochem. 73:1674-1682.
24. Igisu, H., Matsuoka, M., and Iryo, Y. 1995. Protection of the brain by carnitine. Sangyo Eiseigaku Zasshi 37:75-82.
25. Matsuoka, M. and Igisu, H. 1992. Preservation of energy metabolites by carnitine in the mouse brain under ischemia. Brain Res. 590:334-336.
26. Saks, V. A. and Strumia, E. 1993. Phosphocreatine: Molecular and cellular aspects of the mechanism of cardioprotective action. Curr. Ther. Res. 53:565-598.
27. Bralet, J., Bouvier, C., Schreiber, L., and Boquillon, M. 1991. Effect of acidosis on lipid peroxidation in brain slices. Brain Res. 539:175-177.
28. +-ATPase activity. Physiol. Res. 48:73-78.
29. O'Donnell-Tormey, J., Nathan, C. F., Lanks, K., DeBoer, C. J., and De La Harpe, J. 1987. Secretion of pyruvate: An antioxidant defense of mammalian cells. J. Exp. Med. 165:500-514.
30. Shostak, A., Gotloib, L., Kushnier, R., and Wajsbrot, V. 2000. Protective effect of pyruvate upon cultured mesothelial cells exposed to 2 mM hydrogen peroxide. Nephron 84:362-366.
31. Crestanello, J. A., Kamelgard, J., and Whitman, G. J. R. 1995. The cumulative nature of pyruvate's dual mechanism for myocardial protection. J. Surg. Res. 59:198-204.
32. Dobsak, P., Courderot-Masuyer, C., Zeller. M., Vergely, C., Laubriet, A., Assem, M., Eicher, J. C., Teyssier, J. R., Wolf, J. E., and Rochette, L. 1999. Antioxidative properties of pyruvate and protection of the ischemic rat heart during cardioplegia. J. Cardiovasc. Pharmacol. 34:651-659.
33. Salahudeen, A. K., Clark, E. C., and Nath, K. A. 1991. Hydrogen peroxide-induced renal injury: A protective role for pyruvate in vitro and in vivo. J. Clin. Invest. 88:1886-1893.
34. Desagher, S., Glowinski, J., and Prémont, J. 1997. Ryruvate protects neurons against hydrogen peroxide-induced toxicity. J. Neurosci. 17:9060-9067.