Normal tissue complication probability modeling of acute hematologic toxicity in patients treated with intensity-modulated radiation therapy for squamous cell carcinoma of the anal canal

International Journal of Radiation Oncology Biology Physics

Volumn 84, Issue 3, 2012, Pages 700-706

  Bazan, Jose G ^a   Luxton, Gary ^a   Mok, Edward C ^a   Koong, Albert C ^a   Chang, Daniel T ^a  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Anal cancer; Bone marrow toxicity; Intensity modulated radiation therapy; Normal tissue complication probability

Indexed keywords

ANAL CANAL; ANAL CANCER; BONE MARROW; DOSIMETRIC PARAMETER; HEMATOLOGIC TOXICITY; INTENSITY MODULATED RADIATION THERAPY; LOGISTIC REGRESSIONS; LOW DOSE RADIATION; LUMBOSACRAL SPINE; MEAN DOSE; NORMAL TISSUE COMPLICATION PROBABILITIES; PELVIC BONE; SQUAMOUS CELL CARCINOMA; SUBSITES;

BONE; CHEMORADIOTHERAPY; CHEMOTHERAPY; CONSTRAINED OPTIMIZATION; HYDRAULIC STRUCTURES; LOGISTICS; PATIENT MONITORING; PHYSICAL THERAPY; PROBABILITY; TISSUE;

TOXICITY;

CAPECITABINE; ERYTHROPOIETIN; FLUOROURACIL; HEMOGLOBIN; MITOMYCIN C; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ADOLESCENT; ADULT; ANAL CANAL; ANEMIA; ANUS CARCINOMA; ARTICLE; BLOOD TRANSFUSION; BONE MARROW; BONE MASS; CHEMORADIOTHERAPY; CLINICAL ARTICLE; CONTINUOUS INFUSION; DOSIMETRY; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; FEMALE; HEMOGLOBIN BLOOD LEVEL; HUMAN; ILIAC BONE; INTENSITY MODULATED RADIATION THERAPY; LEUKOCYTE COUNT; LEUKOPENIA; LUMBOSACRAL SPINE; LYMAN KUTCHER BURMAN MODEL; MALE; MODEL; MULTIPLE CYCLE TREATMENT; NEUTROPENIA; NEUTROPHIL COUNT; NORMAL TISSUE COMPLICATION PROBABILITY; PELVIC GIRDLE; PRIORITY JOURNAL; PROBABILITY; RADIATION DOSE; SQUAMOUS CELL CARCINOMA; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

ADULT; AGED; AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; ANUS NEOPLASMS; BONE MARROW; CARCINOMA, SQUAMOUS CELL; CHEMORADIOTHERAPY; DEOXYCYTIDINE; FEMALE; FLUOROURACIL; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; ORGANS AT RISK; PELVIC BONES; PROBABILITY; RADIOTHERAPY DOSAGE; RADIOTHERAPY, INTENSITY-MODULATED; RETROSPECTIVE STUDIES;

EID: 84866734154     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.12.072     Document Type: Article

References (19)

1. N.D. Nigro, V.K. Vaitkevicius, and B. Considine Jr. Combined therapy for cancer of the anal canal: A preliminary report Dis Colon Rectum 17 1974 354 356
2. Epidermoid anal cancer: Results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. UKCCCR Anal Cancer Trial Working Party. UK Co-ordinating Committee on Cancer Research Lancet 348 1996 1049 1054
3. H. Bartelink, F. Roelofsen, and F. Eschwege Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: Results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups J Clin Oncol 15 1997 2040 2049
4. M. Flam, M. John, and T.F. Pajak Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: Results of a phase III randomized intergroup study J Clin Oncol 14 1996 2527 2539
5. L.A. W.K. Kachnic, and R.J. Myerson RTOG 0529: A phase II study of dose-painted IMRT (DP-IMRT), 5-fluorouracil, and mitomycin-C for the reduction of acute morbidity in anal cancer [Abstract] J Clin Oncol 29 2011 368
6. J.T. Lyman Complication probability as assessed from dose-volume histograms Radiat Res Suppl 8 1985 S13 S19
7. G.J. Kutcher, and C. Burman Calculation of complication probability factors for non-uniform normal tissue irradiation: The effective volume method Int J Radiat Oncol Biol Phys 16 1989 1623 1630
8. G.J. Kutcher, C. Burman, and L. Brewster Histogram reduction method for calculating complication probabilities for three-dimensional treatment planning evaluations Int J Radiat Oncol Biol Phys 21 1991 137 146
9. R. Mohan, G.S. Mageras, and B. Baldwin Clinically relevant optimization of 3-D conformal treatments Med Phys 19 1992 933 944
10. A. Niemierko Reporting and analyzing dose distributions: A concept of equivalent uniform dose Med Phys 24 1997 103 110
11. B. Emami, J. Lyman, and A. Brown Tolerance of normal tissue to therapeutic irradiation Int J Radiat Oncol Biol Phys 21 1991 109 122
12. G. Luxton, P.J. Keall, and C.R. King A new formula for normal tissue complication probability (NTCP) as a function of equivalent uniform dose (EUD) Phys Med Biol 53 2008 23 36
13. L.K. Mell, D.A. Schomas, and J.K. Salama Association between bone marrow dosimetric parameters and acute hematologic toxicity in anal cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy Int J Radiat Oncol Biol Phys 70 2008 1431 1437
14. K. Albuquerque, D. Giangreco, and C. Morrison Radiation-related predictors of hematologic toxicity after concurrent chemoradiation for cervical cancer and implications for bone marrow-sparing pelvic IMRT Int J Radiat Oncol Biol Phys 79 2011 1043 1047
15. L.K. Mell, J.D. Kochanski, and J.C. Roeske Dosimetric predictors of acute hematologic toxicity in cervical cancer patients treated with concurrent cisplatin and intensity-modulated pelvic radiotherapy Int J Radiat Oncol Biol Phys 66 2006 1356 1365
16. B.S. Rose, B. Aydogan, and Y. Liang Normal tissue complication probability modeling of acute hematologic toxicity in cervical cancer patients treated with chemoradiotherapy Int J Radiat Oncol Biol Phys 79 2011 800 807
17. J.G. Bazan, W. Hara, and A. Hsu Intensity-modulated radiation therapy versus conventional radiation therapy for squamous cell carcinoma of the anal canal Cancer 117 2011 3342 3351
18. A. Trotti, A.D. Colevas, and A. Setser CTCAE v3.0: Development of a comprehensive grading system for the adverse effects of cancer treatment Semin Radiat Oncol 13 2003 176 181
19. M.E. Daly, G. Luxton, and C.Y. Choi Normal tissue complication probability estimation by the Lyman-Kutcher-Burman method does not accurately predict spinal cord tolerance to stereotactic radiosurgery Int J Radiat Oncol Biol Phys 82 2012 2025 2032