A new formula for normal tissue complication probability (NTCP) as a function of equivalent uniform dose (EUD)

Physics in Medicine and Biology

Volumn 53, Issue 1, 2008, Pages 23-36

  Luxton, Gary ^a   Keall, Paul J ^a   King, Christopher R ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALGORITHMS; BIOLOGICAL ORGANS; IRRADIATION; MATHEMATICAL MODELS; PROBABILITY DISTRIBUTIONS;

EQUIVALENT UNIFORM DOSE (EUD); NORMAL TISSUE COMPLICATION PROBABILITY (NTCP);

TISSUE CULTURE;

ANALYTICAL PARAMETERS; ARTICLE; IRRADIATION; MATHEMATICAL COMPUTING; PRIORITY JOURNAL; PROBABILITY; QUANTITATIVE ANALYSIS; RADIATION DOSE; RADIATION DOSE DISTRIBUTION; RADIOCHEMISTRY; RISK ASSESSMENT; THEORETICAL MODEL; TISSUE DISTRIBUTION;

BIOPHYSICS; HUMANS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; NEOPLASMS; ORGAN SPECIFICITY; RADIATION INJURIES; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, CONFORMAL; RADIOTHERAPY, INTENSITY-MODULATED; RISK FACTORS;

EID: 38049045570     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/53/1/002     Document Type: Article

References (19)

1. Abramowitz A and Stegun I A 1964 Handbook of Mathematical Functions (National Bureau of Standards Applied Mathematics Series No. 55) (Washington, DC: US Govt Printing Office) p 10 p 297
2. Belderbos J, Heemsbergen W, Hoogeman M, Pengel K, Rossi M and Lebesque J 2005 Acute esophageal toxicity in non-small cell lung cancer patients after high dose conformal radiotherapy Radiother. Oncol. 75 157-64
3. Burman C, Kutcher G J, Emami B and Goitein M 1991 Fitting of normal tissue tolerance data to an analytic function Int. J. Radiat. Oncol. Biol. Phys. 21 123-35
4. Chapet O, Kong F-M, Lee J S, Hayman J A and Ten Haken R K 2005 Normal tissue complication probability modeling for acute esophagitis in patients treated with conformal radiation therapy for non-small cell lung cancer Radiother. Oncol. 77 176-81
5. Cheung R, Tucker S L, Ye J-S, Dong L, Liu H, Huang E, Mohan R and Kuban D 2004 Characterization of rectal normal tissue complication probability after high-dose external beam radiotherapy for prostate cancer Int. J. Radiat. Oncol. Biol. Phys. 58 1513-9
6. Dawson L A, Normolle D, Balter J M, McGinn C J, Lawrence T S and Ten Haken R K 2002 Analysis of radiation induced liver disease using the Lyman NTCP model Int. J. Radiat. Oncol. Biol. Phys. 53 810-21
7. Eisbruch A, Ten Haken R K, Kim H M, Marsh L H and Ship J A 1999 Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer Int. J. Radiat. Oncol. Biol. Phys 45 577-87
8. Emami B, Lyman J, Brown A, Coia L, Goitein M, Munzenrider J, Shank B, Solin L and Wesson M 1991 Tolerance of normal tissue to therapeutic irradiation Int. J. Radiat. Oncol. Biol. Phys 21 109-22
9. Kutcher G J and Burman C 1989 Calculation of complication probability factors for non-uniform normal tissue irradiation: the effective volume method Int. J. Radiat. Oncol. Biol. Phys. 16 1623-30
10. Kutcher G J, Burman C, Brewster L J, Goitein M and Mohan R 1991 Histogram reduction method for calculating complication probabilities for three-dimensional treatment planning evaluations Int. J. Radiat. Oncol. Biol. Phys. 21 137-46
11. Kwa S L S, Theuws J C M, Wagenaar A, Damen E M, Boersma L J, Baas P, Muller S H and Lebesque J V 1998a Evaluation of two dose-volume histogram reduction models for the prediction of radiation pneumonitis Radiother. Oncol. 48 61-9
12. Kwa S L S et al 1998b Radiation pneumonitis as a function of mean lung dose: an analysis of pooled data of 540 patients Int. J. Radiat. Oncol. Biol. Phys. 42 1-9
13. Lyman J T 1985 Complication probability as assessed from dose-volume histograms Radiat. Res. 104 S13-9
14. Mohan R, Mageras G S, Baldwin B, Brewster L J, Kutcher G J, Leibel S, Burman C M, Ling C C and Fuks Z 1992 Clinically relevant optimization of 3-D conformal treatments Med. Phys. 19 933-44
15. Niemierko A 1997 Reporting and analyzing dose distributions: a concept of equivalent uniform dose Med. Phys. 24 103-10
16. Niemierko A 1999 A generalized concept of equivalent uniform dose (EUD) Med. Phys. 26 1100 (Abstract)
17. Peeters S T H, Hoogeman M S, Heemsbergen W D, Hart A A M, Koper P C M and Lebesque J V 2006 Rectal bleeding, fecal incontinence, and high stool frequency after conformal radiotherapy for prostate cancer: normal tissue complication modeling Int. J. Radiat. Oncol. Biol. Phys. 66 11-9
18. Rancati T et al 2004 Fitting late rectal bleeding data using different NTCP models: results from an Italian multi-centric study (AIROPROS0101) Radiother. Oncol. 73 21-32
19. Seppenwoolde Y, Lebesque J V, de Jaeger K, Belderbos J S A, Boersma L J, Schilstra C, Henning G T, Hayman J A, Martel M K and Ten Haken R K 2003 Comparing different NTCP models that predict the incidence of radiation pneumonitis Int. J. Radiat. Oncol. Biol. Phys. 55 724-35