Increased ferritin levels could reflect ongoing aging-associated inflammation and may obscure underlying iron deficiency in the geriatric population

European Geriatric Medicine

Volumn 3, Issue 5, 2012, Pages 277-280

  Cankurtaran, M ^a   Yavuz, B B ^a   Halil, M ^a   Ulger, Z ^a   Haznedaroglu, I C ^a   Ariogul, S ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Acute phase response; Ferritin; Inflammaging; Inflammation; Iron deficiency

Indexed keywords

ALBUMIN; C REACTIVE PROTEIN; FERRITIN; IRON; TRANSFERRIN;

AGED; AGING; ALBUMIN BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FERRITIN BLOOD LEVEL; GERIATRIC PATIENT; HUMAN; INFLAMMATION; IRON BLOOD LEVEL; IRON DEFICIENCY; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR VOLUME; PRIORITY JOURNAL;

EID: 84866730272     PISSN: 18787649     EISSN: 18787657     Source Type: Journal    
DOI: 10.1016/j.eurger.2012.06.005     Document Type: Article

References (18)

1. G.D. Ginder Microcytic and hypochromic anemias L. Goldman, D. Ausiello, Cecil Medicine 23rd ed. 2008 Saunders, Elsevier Inc Philadelphia 1187 1194
2. C.A. Northrop-Clewes Interpreting indicators of iron status during an acute-phase response-lessons from malaria and human immunodeficiency virus Ann Clin Biochem 45 2008 18 32 (Pubitemid 351724610)
3. I. Aimone-Gastin Biochemical markers of iron status Nephrol Ther 2 Suppl. 5 2006 S321 S326
4. A.M. Konijn Iron metabolism in inflammation Baillieres Clin Haematol 7 1994 829 849
5. P. Lencel, and D. Magne Inflammaging: the driving force in osteoporosis Med Hypotheses 76 2011 317 321
6. J.D. Walston Inflammation and aging J.B. Halter, J.G. Ouslander, M.E. Tinetti, S. Studenski, K.P. High, S. Asthana, Hazzard's geriatric medicine and gerontology 6th ed. 2009 McGraw Hill Co. USA 37 44
7. M. Goto Inflammaging (inflammation + aging): a driving force for human aging based on an evolutionarily antagonistic pleiotropy theory Biosci Trends 2 2008 218 230
8. A.P. Navarrete-Reyes, and M. Montaña-Alvarez Inflammaging. Aging inflammatory origin Rev Invest Clin 61 2009 327 336
9. K.J. Hunt, B.M. Walsh, D. Voegeli, and H.C. Roberts Inflammation in aging part 1: physiology and immunological mechanisms Biol Res Nurs 11 2010 245 252
10. C. Franceschi, M. Bonafe, S. Valensin, F. Olivieri, M. De Luca, and E. Ottaviani Inammaging. An evolutionary perspective on immunosenescence Ann N Y Acad Sci 908 2000 244 254
11. C. Franceschi, and M. Bonafe Centenarians as a model for healthy aging Biochem Soc Trans 31 2003 457 461 (Pubitemid 36520700)
12. S.P. Ballou, F.B. Lozanski, S. Hodder, D.L. Rzewnicki, L.C. Mion, and J.D. Sipe Quantitative and qualitative alterations of acute-phase proteins in healthy elderly persons Age Ageing 25 1996 224 230 (Pubitemid 26152041)
13. H. Bruunsgaard, K. Andersen-Ranberg, B. Jeune, A.N. Pedersen, P. Skinhoj, and B.K. Pedersen A high plasma concentration of TNF-alpha is associated with dementia in centenarians J Gerontol A Biol Sci Med Sci 54 1999 M357 M364
14. H. Bruunsgaard, and B.K. Pedersen Age-related inammatory cytokines and disease Immunol Allergy Clin North Am 23 2003 15 39
15. J. Parkin, and B. Cohen An overview of the immune system Lancet 357 2001 1777 1789 (Pubitemid 32524226)
16. K.S. Krabbe, M. Pedersen, and H. Bruunsgaard Inammatory mediators in the elderly Exp Gerontol 39 2004 687 699
17. K.J. Hunt, B.M. Walsh, D. Voegeli, and H.C. Roberts Inflammation in aging part 2: implications for the health of older people and recommendations for nursing practice Biol Res Nurs 11 2010 253 260
18. S. Serefhanoglu, Y. Buyukasik, H. Emmungil, N. Sayinalp, I.C. Haznedaroglu, and H. Goker Identification of clinical and simple laboratory variables predicting responsible gastrointestinal lesions in patients with iron deficiency anemia Int J Med Sci 28 2010 30 38