Identification of clinical and simple laboratory variables predicting responsible gastrointestinal lesions in patients with iron deficiency anemia

International Journal of Medical Sciences

Volumn 8, Issue 1, 2011, Pages 30-38

  Songul, Serefhanoglu ^a   Buyukasik, Yahya ^a   Emmungil, Hakan ^a   Sayinalp, Nilgun ^a   Haznedaroglu, Ibrahim Celalettin ^a   Goker, Hakan ^a   Aksu, Salih ^a   Ozcebe, Osman Ilhami ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Endoscopic investigation; Gastrointestinal lesions; Iron deficiency anemia; Predictive risk factors

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; HEMOGLOBIN;

ABDOMINAL TENDERNESS; ADULT; AGE; ARTICLE; CHRONIC DIARRHEA; COLONOSCOPY; DEFECATION HABIT; DIAGNOSTIC VALUE; ESOPHAGODUODENOSCOPY; FEMALE; GASTROINTESTINAL DISEASE; GASTROINTESTINAL ENDOSCOPY; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRON DEFICIENCY ANEMIA; MAJOR CLINICAL STUDY; MALE; PREDICTION; PREDICTIVE VALUE; RISK FACTOR; SEX DIFFERENCE; WEIGHT REDUCTION;

EID: 79751510053     PISSN: None     EISSN: 14491907     Source Type: Journal    
DOI: 10.7150/ijms.8.30     Document Type: Article

References (48)

1. Gasche C, Lomer MC, Cavill I, Weiss G. Iron, anaemia, and inflammatory bowel diseases. Gut. 2004; 53: 1190-7.
2. Clark SF. Iron deficiency anemia. Nutr Clin Pract.2008; 23: 128-41.
3. Kepczyk T, Kadakia SC. Prospective evaluation of gastrointestinal tract in patients with iron-deficiency anemia. Dig Dis Sci. 1995; 40: 1283-9.
4. Cook IJ, Pavli P, Riley JW, et al. Gastrointestinal investigation of iron deficiency anaemia. BMJ. 1986; 292: 1380-2.
5. Zuckerman G, Benitez J. A prospective study of bidirectional endoscopy (colonoscopy and upper endoscopy) in the evaluation of patients with occult gastrointestinal bleeding. Am J Gastroenterol. 1992; 87: 62-6.
6. Hardwick RH, Armstrong CP. Synchronous upper and lower gastrointestinal endoscopy is an effective method of investigating iron-deficiency anaemia. Br J Surg. 1997; 84: 1725-8.
7. Rockey DC. Occult gastrointestinal bleeding. Gastroenterol Clin North Am. 2005; 34: 699-718.
8. Powell N, McNair A. Gastrointestinal evaluation of anaemic patients without evidence of iron deficiency. Eur J Gastroenterol Hepatol. 2008; 20: 1094-100.
9. Guyatt GH, Oxman AD, Ali M, et al. Laboratory diagnosis of iron-deficiency anemia: an overview. J Gen Intern Med. 1992; 7: 145-53.
10. Dickey W, McMillan SA, McCrum EE, Evans AE. Association between serum levels of total IgA and IgA class endomysial and antigliadin antibodies: implications for coeliac disease screening. Eur J Gastroenterol Hepatol. 1997; 9: 559-62.
11. McIntyre AS, Long RG. Prospective survey of investigations in outpatients referred with iron deficiency anaemia. Gut 1993; 34: 1102-7.
12. Lindsay JO, Robinson SD, Jackson JE, Walters JR: The investigation of iron deficiency anemia - a hospital based audit. Hepatogastroenterology. 1999; 46: 2887-90.
13. Majid S, Salih M, Wasaya R, Jafri W. Predictors of gastrointestinal lesions on endoscopy in iron deficiency anemia without gastrointestinal symptoms. BMC Gastroenterology. 2008; 8: 52.
14. Zhu A, Kaneshiro M, Kaunitz JD. Evaluation and treatment of iron deficiency anemia: a gastroenterological perspective. Dig Dis Sci. 2010; 55: 548-59.
15. Alleyne M, Horne MK, Miller JL. Individualized treatment for iron-deficiency anemia in adults. Am J Med. 2008; 121: 943-8.
16. Lee JG, Sahagun G, Oehlke MA, Lieberman DA. Serious gastrointestinal pathology found in patients with serum ferritin values #50 ng/ ml. Am J Gastroenterol. 1998; 93: 772-6.
17. Ioannou GN, Spector J, Scott K, Rockey DC. Prospective evaluation of a clinical guideline for the diagnosis and management of iron deficiency anemia. Am J Med. 2002; 113: 281-7.
18. Zuckerman GR, Prakash C, Askin MP, Lewis BS. American Gastroenterological Association medical position statement: evaluation and management of occult and obscure gastrointestinal bleeding. Gastroenterology. 2000; 118: 197-201.
19. Tan YM, Rosmawati M, Ranjeev P, Goh KL. Predictive factors by multivariate analysis for colorectal cancer in Malaysian patients undergoing colonoscopy. J Gastroenterol Hepatol. 2002; 97: 590-3.
20. Sworczak K, Siekierska HM, Drobinska A, et al. Iron deficiency anemia as the sole symptom of small intestine carcinoma. Med Sci Monit. 2001; 7: 457-60.
21. Rockey DC. Gastrointestinal bleeding. In: Feldman M, Friedman LS, Sleisneger MH, eds. Gastrointestinal and Liver Disease; 7th edn, vol 1. Philadelphia: WB Saunders, 2002: 221-48.
22. Gordon SR, Smith R, Power GC. The role of endoscopy in the evaluation of iron deficiency anemia in patients over the age of 50. Am J Gastroenterol. 1994; 89: 1963-7.
23. Fireman Z, Gurevich V, Coscas D, et al. Results of gastrointestinal evaluation of hospitalized patients with iron deficiency anemia. IMAJ. 1999; 1: 232-5.
24. Wilcox CM, Alexander LN, Clark WS. Prospective evaluation of the gastrointestinal tract in patients with iron deficiency and no systemic or gastrointestinal symptoms or signs. Am J Med. 1997; 103: 405-9.
25. Peterson WL. Gastrointestinal bleeding. In: Sleisenger MH, Fordtran JS, eds. Gastrointestinal disease; 4th ed; Vol 1. Philadelphia: WB Saunders, 1989: 415-6.
26. Ahlquist DA. Approach to the patient with occult gastrointestinal bleeding. In: Yamada T, ed. Textbook of gastroenterology; Vol 1. Philadelphia: JB Lippincott, 1991: 616-33.
27. Goddard AF, McIntyre AS, Scott BB. Guidelines for the management of iron deficiency anemia for the British Society of Gastroenterology. Gut. 2000; 46: 1-5.
28. Rockey DC, Cello JP. Evaluation of gastrointestinal tract in patients with iron deficiency anemia. N Engl J Med. 1993; 329: 1691-5.
29. Bini EJ, Micale PL, Weinshel EH. Evaluation of the gastrointestinal tract in premenopausal women with iron deficiency anemia. Am J Med. 1998; 105: 281-6.
30. Rockey DC. Occult gastrointestinal bleeding. N Engl J Med. 1999; 341: 38-48.
31. Bampton PA, Holloway RH. A prospective study of the gastroenterological causes of iron deficiency anaemia in a general hospital. Aust N Z J Med. 1996; 26: 793-9.
32. Till SH, Grundman MJ. Prevalence of concomitant disease in patients with iron deficiency anaemia. Br Med J. 1997; 314: 206-8.
33. Ioannou GN, Rockey DC, Bryson CL, Weiss NS. Iron deficiency and gastrointestinal malignancy: A population-based cohort study. Am J Med. 2002; 113: 276-80.
34. McIntyre AS, Long RG. Prospective survey of investigations in outpatients referred with iron deficiency anemia. Gut. 1993; 34: 1102-7.
35. Joosten E, Ghesquiere B, Linthoudt H, et al. Upper and lower gastrointestinal evaluation of elderly inpatients who are iron deficient. Am J Med. 1999; 107: 24-9.
36. Capurso G, Baccini F, Osborn J, et al. Can patient characteristics predict the outcome of endoscopic evaluation of iron deficiency anemia: a multiple logistic regression analysis. Gastrointest Endosc. 2004; 59: 766-71.
37. Green BT, Rockey DC. Gastrointestinal endoscopic evaluation of premenopausal women with iron deficiency anemia. J Clin Gastroenterol. 2004; 38: 104-9.
38. Kepczyk T, Cremins JE, Long BD, et al. A prospective, multidisciplinary evaluation of premenopausal women with iron-deficiency anemia. Am J Gastroenterol. 1999; 94: 109-15.
39. Nahon S, Lahmek P, Lesgourgues B, et al. Predictive factors of GI lesions in 241 women with iron deficiency anemia. Am J Gastroenterol. 2002; 97: 590-653.
40. Konno M, Muraoka S, Takahashi M, Imai T. Iron-deficiency anemia associated with Helicobacter pyl ori gastriti s. J Ped Gastr Nutr. 2000; 31: 52-6.
41. Choe YH, Kim SK, Son BK, et al. Randomized placebo controlled trial of Helicobacter pylori eradication for iron-deficiency anemia in preadolescent children and adolescents. Helicobacter. 1999; 4: 135-9.
42. Choe YH, Lee JE, Kim SK. Effect of helicobacter pylori eradication on sideropenic refractory anaemia in adolescent girls with Helicobacter pylori infection. Acta Paediatr. 2000; 89: 154-7.
43. Choe YH, Hwang TS, Kim HJ, et al. A possible relation of the Helicobacter pylori Pfr gene to iron deficiency anemia? Helicobacter. 2001; 6: 55-9.
44. Choe YH, Kwon YS, Jung MK, et al. Helicobacter pylori- associated iron-deficiency anemia in adolescent female athletes. J Pediatr. 2001; 139: 100-4.
45. Ashorn M, Ruuska T, Makipernaa A. Helicobacter pylori and iron deficiency anaemia in children. Scand J Gastr. 2001; 36: 701-5.
46. Annibale B, Marignani M, Monarca B, et al. Reversal of iron deficiency anemia after Helicobacter pylori eradication in patients with asymptomatic gastritis. Ann Intern Med. 1999; 131: 668-72.
47. Hershko, C, Hoffbrand, AV, Keret, D et al. Role of autoimmune gastritis, Helicobacter pylori and celiac disease in refractory or unexplained iron deficiency anemia. Haematologica. 2005; 90: 585-95.
48. Grisolano SW, Oxentenko AS, Murray JA, et al. The usefulness of routine small bowel biopsies in evaluation of iron deficiency anemia. J Clin Gastroenterol. 2004; 38: 756-60.