Cataract-associated D3Y mutation of human connexin46 (hCx46) increases the dye coupling of gap junction channels and suppresses the voltage sensitivity of hemichannels

Journal of Bioenergetics and Biomembranes

Volumn 44, Issue 5, 2012, Pages 607-614

  Schlingmann, Barbara ^a,b   Schadzek, Patrik ^a   Busko, Stefan ^a   Heisterkamp, Alexander ^c   Ngezahayo, Anaclet ^a,b  

^a LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^b CENTER FOR SYSTEMS NEUROSCIENCE   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Cataract; Dye transfer; HCx46; Hemichannels; N terminus; Voltage sensitivity

Indexed keywords

ASPARTIC ACID; CONNEXIN 46; CONNEXIN 50; ENHANCED GREEN FLUORESCENT PROTEIN; ETHIDIUM BROMIDE; GAP JUNCTION PROTEIN; GLUTAMIC ACID; LUCIFER YELLOW; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CATARACT; CONTROLLED STUDY; GAP JUNCTION; GENE EXPRESSION; GENE MUTATION; HELA CELL; HOMEOSTASIS; LENS FIBER; METABOLITE; NONHUMAN; OOCYTE; VOLTAGE CLAMP; VOLTAGE SENSITIVE DYE IMAGING; XENOPUS;

AMINO ACID SUBSTITUTION; ANIMALS; CATARACT; CONNEXINS; ETHIDIUM; EYE DISEASES, HEREDITARY; FLUORESCENT DYES; GAP JUNCTIONS; HELA CELLS; HUMANS; ISOQUINOLINES; MUTATION, MISSENSE; XENOPUS LAEVIS;

EID: 84866729303     PISSN: 0145479X     EISSN: 15736881     Source Type: Journal    
DOI: 10.1007/s10863-012-9461-0     Document Type: Article

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