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Volumn 7, Issue 9, 2012, Pages

IP-FCM Measures Physiologic Protein-Protein Interactions Modulated by Signal Transduction and Small-Molecule Drug Inhibition

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; AMPICILLIN; BIOTIN; CYCLOHEXIMIDE; FC RECEPTOR; GENTAMICIN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; KANAMYCIN; LYMPHOCYTE ANTIGEN RECEPTOR; PHENYL PHOSPHATE; PHLEOMYCIN; PROTEIN INHIBITOR; PROTEIN KINASE ZAP 70; RO 26 4550; UNCLASSIFIED DRUG;

EID: 84866719263     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045722     Document Type: Article
Times cited : (15)

References (28)
  • 1
    • 70349838218 scopus 로고    scopus 로고
    • Cytokines and CNS development
    • Deverman BE, Patterson PH, (2009) Cytokines and CNS development. Neuron 64: 61-78.
    • (2009) Neuron , vol.64 , pp. 61-78
    • Deverman, B.E.1    Patterson, P.H.2
  • 2
    • 84855957129 scopus 로고    scopus 로고
    • How the TCR balances sensitivity and specificity for the recognition of self and pathogens
    • Morris GP, Allen PM, (2012) How the TCR balances sensitivity and specificity for the recognition of self and pathogens. Nat Immunol 13: 121-128.
    • (2012) Nat Immunol , vol.13 , pp. 121-128
    • Morris, G.P.1    Allen, P.M.2
  • 3
    • 33646177549 scopus 로고    scopus 로고
    • At the heart of the chromosome: SMC proteins in action
    • Hirano T, (2006) At the heart of the chromosome: SMC proteins in action. Nat Rev Mol Cell Biol 7: 311-322.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 311-322
    • Hirano, T.1
  • 5
    • 29944435762 scopus 로고    scopus 로고
    • The emerging role of the COP9 signalosome in cancer
    • Richardson KS, Zundel W, (2005) The emerging role of the COP9 signalosome in cancer. Mol Cancer Res 3: 645-653.
    • (2005) Mol Cancer Res , vol.3 , pp. 645-653
    • Richardson, K.S.1    Zundel, W.2
  • 6
    • 0030072624 scopus 로고    scopus 로고
    • High-throughput screening strategies to identify inhibitors of protein-protein interactions
    • Kay BK, Paul JI, (1996) High-throughput screening strategies to identify inhibitors of protein-protein interactions. Mol Divers 1: 139-140.
    • (1996) Mol Divers , vol.1 , pp. 139-140
    • Kay, B.K.1    Paul, J.I.2
  • 7
    • 3142781225 scopus 로고    scopus 로고
    • Small-molecule inhibitors of protein-protein interactions: progressing towards the dream
    • Arkin MR, Wells JA, (2004) Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat Rev Drug Discov 3: 301-317.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 301-317
    • Arkin, M.R.1    Wells, J.A.2
  • 8
    • 57649138736 scopus 로고    scopus 로고
    • Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles
    • Blazer LL, Neubig RR, (2009) Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles. Neuropsychopharmacology 34: 126-141.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 126-141
    • Blazer, L.L.1    Neubig, R.R.2
  • 9
    • 50649121848 scopus 로고    scopus 로고
    • Identification of chemical inhibitors of protein-kinase CK2 subunit interaction
    • Laudet B, Moucadel V, Prudent R, Filhol O, Wong YS, et al. (2008) Identification of chemical inhibitors of protein-kinase CK2 subunit interaction. Mol Cell Biochem 316: 63-69.
    • (2008) Mol Cell Biochem , vol.316 , pp. 63-69
    • Laudet, B.1    Moucadel, V.2    Prudent, R.3    Filhol, O.4    Wong, Y.S.5
  • 10
    • 32944470373 scopus 로고    scopus 로고
    • A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells
    • Stallings-Mann M, Jamieson L, Regala RP, Weems C, Murray NR, et al. (2006) A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells. Cancer Res 66: 1767-1774.
    • (2006) Cancer Res , vol.66 , pp. 1767-1774
    • Stallings-Mann, M.1    Jamieson, L.2    Regala, R.P.3    Weems, C.4    Murray, N.R.5
  • 11
    • 51349160681 scopus 로고    scopus 로고
    • High-throughput screening assays to discover small-molecule inhibitors of protein interactions
    • Colas P, (2008) High-throughput screening assays to discover small-molecule inhibitors of protein interactions. Curr Drug Discov Technol 5: 190-199.
    • (2008) Curr Drug Discov Technol , vol.5 , pp. 190-199
    • Colas, P.1
  • 12
    • 84858451531 scopus 로고    scopus 로고
    • Multiplex IP-FCM (immunoprecipitation-flow cytometry): Principles and guidelines for assessing physiologic protein-protein interactions in multiprotein complexes
    • Bida AT, Gil D, Schrum AG, (2011) Multiplex IP-FCM (immunoprecipitation-flow cytometry): Principles and guidelines for assessing physiologic protein-protein interactions in multiprotein complexes. Methods 56: 154-160.
    • (2011) Methods , vol.56 , pp. 154-160
    • Bida, A.T.1    Gil, D.2    Schrum, A.G.3
  • 13
    • 80055116623 scopus 로고    scopus 로고
    • IP-FCM: immunoprecipitation detected by flow cytometry
    • Davis TR, Schrum AG (2010) IP-FCM: immunoprecipitation detected by flow cytometry. J Vis Exp.
    • (2010) J Vis Exp
    • Davis, T.R.1    Schrum, A.G.2
  • 14
    • 70549110905 scopus 로고    scopus 로고
    • Visualization of multiprotein complexes by flow cytometry
    • Schrum AG (2009) Visualization of multiprotein complexes by flow cytometry. Curr Protoc Immunol Chapter 5: Unit5 9.
    • (2009) Curr Protoc Immunol , pp. 9
    • Schrum, A.G.1
  • 15
    • 34250684995 scopus 로고    scopus 로고
    • High-sensitivity detection and quantitative analysis of native protein-protein interactions and multiprotein complexes by flow cytometry
    • Schrum AG, Gil D, Dopfer EP, Wiest DL, Turka LA, et al. (2007) High-sensitivity detection and quantitative analysis of native protein-protein interactions and multiprotein complexes by flow cytometry. Sci STKE 2007: pl2.
    • (2007) Sci STKE , vol.2007
    • Schrum, A.G.1    Gil, D.2    Dopfer, E.P.3    Wiest, D.L.4    Turka, L.A.5
  • 16
    • 79960484634 scopus 로고    scopus 로고
    • Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells
    • Schrum AG, Gil D, Turka LA, Palmer E, (2011) Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells. J Immunol 187: 870-878.
    • (2011) J Immunol , vol.187 , pp. 870-878
    • Schrum, A.G.1    Gil, D.2    Turka, L.A.3    Palmer, E.4
  • 17
    • 84862868473 scopus 로고    scopus 로고
    • Small-molecule inhibitors of IL-2/IL-2R: lessons learned and applied
    • Wilson CG, Arkin MR, (2010) Small-molecule inhibitors of IL-2/IL-2R: lessons learned and applied. Curr Top Microbiol Immunol 348: 25-59.
    • (2010) Curr Top Microbiol Immunol , vol.348 , pp. 25-59
    • Wilson, C.G.1    Arkin, M.R.2
  • 18
    • 33751376416 scopus 로고    scopus 로고
    • A novel source of viable peripheral blood mononuclear cells from leukoreduction system chambers
    • Dietz AB, Bulur PA, Emery RL, Winters JL, Epps DE, et al. (2006) A novel source of viable peripheral blood mononuclear cells from leukoreduction system chambers. Transfusion 46: 2083-2089.
    • (2006) Transfusion , vol.46 , pp. 2083-2089
    • Dietz, A.B.1    Bulur, P.A.2    Emery, R.L.3    Winters, J.L.4    Epps, D.E.5
  • 19
    • 79951815697 scopus 로고    scopus 로고
    • Basal and antigen-induced exposure of the proline-rich sequence in CD3epsilon
    • de la Cruz J, Kruger T, Parks CA, Silge RL, van Oers NS, et al. (2011) Basal and antigen-induced exposure of the proline-rich sequence in CD3epsilon. J Immunol 186: 2282-2290.
    • (2011) J Immunol , vol.186 , pp. 2282-2290
    • de la Cruz, J.1    Kruger, T.2    Parks, C.A.3    Silge, R.L.4    van Oers, N.S.5
  • 20
    • 14244262563 scopus 로고    scopus 로고
    • T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes
    • Gil D, Schrum AG, Alarcon B, Palmer E, (2005) T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes. J Exp Med 201: 517-522.
    • (2005) J Exp Med , vol.201 , pp. 517-522
    • Gil, D.1    Schrum, A.G.2    Alarcon, B.3    Palmer, E.4
  • 21
    • 44849104684 scopus 로고    scopus 로고
    • A role for CD8 in the developmental tuning of antigen recognition and CD3 conformational change
    • Gil D, Schrum AG, Daniels MA, Palmer E, (2008) A role for CD8 in the developmental tuning of antigen recognition and CD3 conformational change. J Immunol 180: 3900-3909.
    • (2008) J Immunol , vol.180 , pp. 3900-3909
    • Gil, D.1    Schrum, A.G.2    Daniels, M.A.3    Palmer, E.4
  • 22
    • 0345415723 scopus 로고    scopus 로고
    • Surface T-cell antigen receptor expression and availability for long-term antigenic signaling
    • Schrum AG, Turka LA, Palmer E, (2003) Surface T-cell antigen receptor expression and availability for long-term antigenic signaling. Immunol Rev 196: 7-24.
    • (2003) Immunol Rev , vol.196 , pp. 7-24
    • Schrum, A.G.1    Turka, L.A.2    Palmer, E.3
  • 24
    • 0037191792 scopus 로고    scopus 로고
    • Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes
    • Stefanova I, Dorfman JR, Germain RN, (2002) Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature 420: 429-434.
    • (2002) Nature , vol.420 , pp. 429-434
    • Stefanova, I.1    Dorfman, J.R.2    Germain, R.N.3
  • 25
    • 0030753124 scopus 로고    scopus 로고
    • Identification of a Small Molecule Inhibitor of the IL-2/IL-2RŒ± Receptor Interaction Which Binds to IL-2
    • Tilley JW, Chen L, Fry DC, Emerson SD, Powers GD, et al. (1997) Identification of a Small Molecule Inhibitor of the IL-2/IL-2RŒ± Receptor Interaction Which Binds to IL-2. Journal of the American Chemical Society 119: 7589-7590.
    • (1997) Journal of the American Chemical Society , vol.119 , pp. 7589-7590
    • Tilley, J.W.1    Chen, L.2    Fry, D.C.3    Emerson, S.D.4    Powers, G.D.5
  • 26
    • 2542643984 scopus 로고    scopus 로고
    • Integrating Fragment Assembly and Biophysical Methods in the Chemical Advancement of Small-Molecule Antagonists of IL-2: Äâ An Approach for Inhibiting Protein, àíProtein Interactions'Ć
    • Raimundo BC, Oslob JD, Braisted AC, Hyde J, McDowell RS, et al. (2004) Integrating Fragment Assembly and Biophysical Methods in the Chemical Advancement of Small-Molecule Antagonists of IL-2: Äâ An Approach for Inhibiting Protein, àíProtein Interactions'Ć. Journal of Medicinal Chemistry 47: 3111-3130.
    • (2004) Journal of Medicinal Chemistry , vol.47 , pp. 3111-3130
    • Raimundo, B.C.1    Oslob, J.D.2    Braisted, A.C.3    Hyde, J.4    McDowell, R.S.5
  • 27
    • 34548418142 scopus 로고    scopus 로고
    • Methods for the detection and analysis of protein-protein interactions
    • Berggard T, Linse S, James P, (2007) Methods for the detection and analysis of protein-protein interactions. Proteomics 7: 2833-2842.
    • (2007) Proteomics , vol.7 , pp. 2833-2842
    • Berggard, T.1    Linse, S.2    James, P.3
  • 28
    • 84857712365 scopus 로고    scopus 로고
    • Protein-protein interaction inhibitors get into the groove
    • Mullard A, (2012) Protein-protein interaction inhibitors get into the groove. Nat Rev Drug Discov 11: 173-175.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 173-175
    • Mullard, A.1


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