Ex Vivo and In Silico Feasibility Study of Monitoring Electric Field Distribution in Tissue during Electroporation Based Treatments

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Kranjc, Matej ^a   Bajd, Franci ^b   Sersa, Igor ^b   Woo, Eung Je ^c   Miklavcic, Damijan ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b JO EF STEFAN INSTITUTE   (Slovenia)

^c Kyung Hee University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL TISSUE; ARTICLE; COMPUTER ASSISTED IMPEDANCE TOMOGRAPHY; COMPUTER MODEL; CONDUCTANCE; CONTROLLED STUDY; ELECTRIC FIELD; ELECTROCHEMOTHERAPY; ELECTROPORATION; EX VIVO STUDY; FEASIBILITY STUDY; IMAGE ANALYSIS; IMAGE RECONSTRUCTION; MAGNETIC RESONANCE ELECTRICAL IMPEDANCE TOMOGRAPHY; NONHUMAN; SIMULATION; TISSUE DISTRIBUTION;

ANIMALS; CHICKENS; ELECTRIC IMPEDANCE; ELECTROPORATION; FEASIBILITY STUDIES; TOMOGRAPHY;

EID: 84866710516     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045737     Document Type: Article

References (36)

1. Mir LM, Orlowski S, (1999) Mechanisms of electrochemotherapy. Adv Drug Deliv Rev 35: 107-118.
2. Neumann E, Schaeferridder M, Wang Y, Hofschneider P, (1982) Gene-Transfer into Mouse Lyoma Cells by Electroporation in High Electric-Fields. EMBO J 1: 841-845.
3. Kotnik T, Pucihar G, Miklavcic D, (2010) Induced Transmembrane Voltage and Its Correlation with Electroporation-Mediated Molecular Transport. J Membrane Biol 236: 3-13.
4. Orlowski S, Belehradek J, Paoletti C, Mir LM, (1988) Transient electropermeabilization of cells in culture. Increase of the cytotoxicity of anticancer drugs. Biochem Pharmacol 37: 4727-4733.
5. Sersa G, Cemazar M, Miklavcic D, (1995) Antitumor Effectiveness of Electrochemotherapy with cis-Diamminedichloroplatinum(II) in Mice. Cancer Res 55: 3450-3455.
6. Marty M, Sersa G, Garbay JR, Gehl J, Collins CG, et al. (2006) Electrochemotherapy- An easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study. EJC Suppl 4: 3-13.
7. Sersa G, Miklavcic D (2008) Electrochemotherapy of Tumours. JoVE. Available: http://www.jove.com/index/Details.stp?ID=1038.
8. Sersa G, Cufer T, Paulin SM, Cemazar M, Snoj M, (2012) Electrochemotherapy of chest wall breast cancer recurrence. Cancer Treat Rev 5: 379-386.
9. Garcia PA, Pancotto T, Rossmeisl JH, Henao-Guerrero N, Gustafson NR, et al. (2011) Non-Thermal Irreversible Electroporation (N-TIRE) and Adjuvant Fractionated Radiotherapeutic Multimodal Therapy for Intracranial Malignant Glioma in a Canine Patient. Technol Cancer Res Treat 10: 73-83.
10. Rubinsky J, Onik G, Mikus P, Rubinsky B, (2008) Optimal parameters for the destruction of prostate cancer using irreversible electroporation. J Urol 180: 2668-2674.
11. Edhemovic I, Gadzijev EM, Brecelj E, Miklavcic D, Kos B, et al. (2011) Electrochemotherapy: a new technological approach in treatment of metastases in the liver. Technol Cancer Res Treat 10: 475-485.
12. Thomson KR, Cheung W, Ellis SJ, Federman D, Kavnoudias H, et al. (2011) Investigation of the safety of irreversible electroporation in humans. J Vasc Interv Radiol 22: 611-621.
13. Miklavcic D, Beravs K, Semrov D, Cemazar M, Demsar F, et al. (1998) The Importance of Electric Field Distribution for Effective in Vivo Electroporation of Tissues. Biophys J 74: 2152-2158.
14. Miklavcic D, Snoj M, Zupanic A, Kos B, Cemazar M, et al. (2010) Towards treatment planning and treatment of deep-seated solid tumors by electrochemotherapy. Biomed Eng Online 9: 10.
15. Zupanic A, Kos B, Miklavcic D, (2012) Treatment planning of electroporation-based medical interventions: electrochemotherapy, gene electrotransfer and irreversible electroporation. Physics in Medicine and Biology 57: 5425-5440 doi:10.1088/0031-9155/57/17/5425.
16. Pavlin M, Kanduser M, Rebersek M, Pucihar G, Hart FX, et al. (2005) Effect of cell electroporation on the conductivity of a cell suspension. Biophys J 88: 4378-4390 doi:10.1529/biophysj.104.048975.
17. Cukjati D, Batiuskaite D, André F, Miklavcic D, Mir LM, (2007) Real time electroporation control for accurate and safe in vivo non-viral gene therapy. Bioelectrochemistry 70: 501-507 doi:10.1016/j.bioelechem.2006.11.001.
18. Kos B, Zupanic A, Kotnik T, Snoj M, Sersa G, et al. (2010) Robustness of Treatment Planning for Electrochemotherapy of Deep-Seated Tumors. J Membrane Biol 236: 147-153.
19. Pavliha D, Kos B, Zupanic A, Marcan M, Sersa G, et al. (2012) Patient-specific treatment planning of electrochemotherapy: Procedure design and possible pitfalls. Bioelectrochemistry: In press. doi:10.1016/j.bioelechem.2012.01.007.
20. Granot Y, Ivorra A, Maor E, Rubinsky B, (2009) In vivo imaging of irreversible electroporation by means of electrical impedance tomography. Phys Med Biol 54: 4927-4943 doi:10.1088/0031-9155/54/16/006.
21. Ivorra A, Rubinsky B, (2007) In vivo electrical impedance measurements during and after electroporation of rat liver. Bioelectrochemistry 70: 287-295 doi:10.1016/j.bioelechem.2006.10.005.
22. Zhang Y, Guo Y, Ragin AB, Lewandowski RJ, Yang G-Y, et al. (2010) MR Imaging to Assess Immediate Response to Irreversible Electroporation for Targeted Ablation of Liver Tissues: Preclinical Feasibility Studies in a Rodent Model1. Radiology 256: 424-432 doi:10.1148/radiol.10091955.
23. Lee EW, Chen C, Prieto VE, Dry SM, Loh CT, et al. (2010) Advanced Hepatic Ablation Technique for Creating Complete Cell Death: Irreversible Electroporation. Radiology 255: 426-433 doi:10.1148/radiol.10090337.
24. Kranjc M, Bajd F, Sersa I, Miklavcic D, (2011) Magnetic Resonance Electrical Impedance Tomography for Monitoring Electric Field Distribution During Tissue Electroporation. IEEE Trans Med Imaging 30: 1771-1778.
25. Miklavcic D, Semrov D, Mekid H, Mir LM, (2000) A validated model of in vivo electric field distribution in tissues for electrochemotherapy and for DNA electrotransfer for gene therapy. Biochim Biophys Acta 1523: 73-83.
26. Pucihar G, Krmelj J, Rebersek M, Napotnik TB, Miklavcic D, (2011) Equivalent pulse parameters for electroporation. IEEE Trans Biomed Eng 58: 3279-3288 doi:10.1109/TBME.2011.2167232.
27. Khang HS, Lee BI, Oh SH, Woo EJ, Lee SY, et al. (2002) J-substitution algorithm in Magnetic Resonance Electrical Impedance Tomography (MREIT): Phantom experiments for static resistivity images. IEEE Trans Med Imaging 21: 695-702.
28. Kwon O, Woo E, Yoon J, Seo J, (2002) Magnetic resonance electrical impedance tomography (MREIT): Simulation study of J-substitution algorithm. IEEE Trans Biomed Eng 49: 160-167.
29. Sersa I, Jarh O, Demsar F, (1994) Magnetic Resonance Microscopy of Electric Currents. J Magn Reson 111: 93-99 doi:10.1006/jmra.1994.1230.
30. Sersa I, (2008) Auxiliary phase encoding in multi spin-echo sequences: application to rapid current density imaging. J Magn Reson 190: 86-94 doi:10.1016/j.jmr.2007.10.009.
31. Sel D, Cukjati D, Batiuskaite D, Slivnik T, Mir LM, et al. (2005) Sequential finite element model of tissue electropermeabilization. IEEE Trans Biomed Eng 52: 816-827 doi:10.1109/TBME.2005.845212.
32. Corovic S, Zupanic A, Miklavcic D, (2008) Numerical Modeling and Optimization of Electric Field Distribution in Subcutaneous Tumor Treated With Electrochemotherapy Using Needle Electrodes. IEEE Trans Plasma Sci IEEE Nucl Plasma Sci Soc 36: 1665-1672 doi:10.1109/TPS.2008.2000996.
33. Essone Mezeme M, Pucihar G, Pavlin M, Brosseau C, Miklavcic D, (2012) A numerical analysis of multicellular environment for modeling tissue electroporation. Appl Phys Lett 100: 143701.
34. Ivorra A, Al-Sakere B, Rubinsky B, Mir LM, (2009) In vivo electrical conductivity measurements during and after tumor electroporation: conductivity changes reflect the treatment outcome. Phys Med Biol 54: 5949-5963.
35. Kim S, Kwon O, Seo J, Yoon J, (2003) On a nonlinear partial differential equation arising in magnetic resonance electrical impedance tomography. SIAM J Appl Math 34: 511-526.
36. Seo JK, Woo EJ, (2011) Magnetic Resonance Electrical Impedance Tomography (MREIT). SIAM Rev 53: 40.