What happened: The chemistry side of the incident with EMS contamination in Viracept tablets

Toxicology Letters

Volumn 190, Issue 3, 2009, Pages 248-253

  Gerber, Christoph ^a   Toelle, Heinz Gerhard ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Analytical method development; Ethyl methane sulfonate; Nelfinavir mesilate; Patient exposure; Stability study; Viracept

Indexed keywords

MESYLIC ACID ETHYL ESTER; MESYLIC ACID METHYL ESTER; NELFINAVIR;

ARTICLE; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); DERIVATIZATION; DRUG COATING; DRUG CONTAMINATION; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG HALF LIFE; DRUG IMPURITY; DRUG MANUFACTURE; DRUG QUALITY; DRUG SAFETY; DRUG SCREENING; DRUG STABILITY; DRUG STORAGE; DRUG STRUCTURE; DRUG SYNTHESIS; GENOTOXICITY; HEALTH HAZARD; HUMAN; MASS FRAGMENTOGRAPHY; PRIORITY JOURNAL; QUALITY CONTROL; RECOMMENDED DRUG DOSE; REFERENCE VALUE; STORAGE TEMPERATURE; TABLET FORMULATION; TEMPERATURE SENSITIVITY;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CONTAMINATION; ENVIRONMENTAL EXPOSURE; ETHYL METHANESULFONATE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HIV PROTEASE INHIBITORS; HUMANS; MUTAGENS; NELFINAVIR; PRODUCT SURVEILLANCE, POSTMARKETING; TABLETS;

EID: 69549149575     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.02.020     Document Type: Article

References (5)

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