Enemy or partner: Relationship between intronic micrornas and their host genes

IUBMB Life

Volumn 64, Issue 10, 2012, Pages 835-840

  Gao, Xu ^a   Qiao, Yu ^a   Han, Dong ^a   Zhang, Yanfen ^a   Ma, Ning ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

antagonistic; coexpression; host gene; intronic microRNA; synergetic

Indexed keywords

INTRONIC MICRORNA; MICRORNA; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; BIOLOGICAL FUNCTIONS; GENE; GENE EXPRESSION; GENE FUNCTION; GENE INTERACTION; GENETIC TRANSCRIPTION; HUMAN; INTRON; MEDICAL LITERATURE; NEGATIVE FEEDBACK; NONHUMAN; REVIEW; TUMOR CELL;

ANIMALS; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; HUMANS; INTRONS; MICE; MICRORNAS; ORGAN SPECIFICITY;

EID: 84866695456     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.1079     Document Type: Review

References (56)

1. Årom, U. A., Nielsen, F. C., and, Lund, A. H., (2008) MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. Mol. Cell 30, 460-471.
2. Tay, Y., Zhang, J., Thomson, A. M., Lim, B., and, Rigoutsos, I., (2008) MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature 455, 1124-1128.
3. Place, R. F., Li, L. C., Pookot, D., Noonan, E. J., and, Dahiya, R., (2008) MicroRNA-373 induces expression of genes with complementary promoter sequences. Proc. Natl. Acad. Sci. USA 105, 1608-1613.
4. Eiring, A. M., Harb, J. G., Neviani, P., Garton, C., Oaks, J. J., et al. (2010) miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell 140, 652-665.
5. Kim, D. H., Saetrom, P., SnÃve, O. Jr., and, Rossi, J. J., (2008) MicroRNA-directed transcriptional gene silencing in mammalian cells. Proc. Natl. Acad. Sci. USA 105, 16230-16235.
6. Fazi, F., Rosa, A., Fatica, A., Gelmetti, V., De Marchis, M. L., et al. (2005) A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell 123, 819-831.
7. Bartel, D. P., (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297.
8. Meng, Y., and, Shao, C., (2012) Large-scale identification of mirtrons in Arabidopsis and rice. PLoS One 7, e31163.
9. Voinnet, O., (2009) Origin, biogenesis, and activity of plant microRNAs. Cell 136, 669-687.
10. Van Rooij, E., Sutherland, L. B., Qi, X., Richardson, J. A., Hill, J., et al. (2007) Control of stress-dependent cardiac growth and gene expression by a microRNA. Science 316, 575-579.
11. Najafi-Shoushtari, S. H., Kristo, F., Li, Y., Shioda, T., Cohen, D. E., et al. (2010) MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science 328, 1566-1569.
12. Grady, W. M., Parkin, R. K., Mitchell, P. S., Lee, J. H., Kim, Y.-H., et al. (2008) Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer. Oncogene 27, 3880-3888.
13. Dill, H., Linder, B., Fehr, A., and, Fischer, U., (2012) Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2. Genes Dev. 26, 25-30.
14. Han, J., Denli, A. M., and, Gage, F. H., (2012) The enemy within: intronic miR-26b represses its host gene, ctdsp2, to regulate neurogenesis. Genes Dev. 26, 6-10.
15. Zhu, Y., Lu, Y., Zhang, Q., Liu, J. J., Li, T. J., et al. (2012) MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein. Nucleic Acids Res 40, 4615-4625.
16. Ma, N., Wang, X., Qiao, Y., Li, F., Hui, Y., et al. (2011) Coexpression of an intronic microRNA and its host gene reveals a potential role for miR-483-5p as an IGF2 partner. Mol. Cell Endocrinol. 333, 96-101.
17. Cao, G., Huang, B., Liu, Z., Zhang, J., Xu, H., et al. (2010) Intronic miR-301 feedback regulates its host gene, ska2, in A549 cells by targeting MEOX2 to affect ERK/CREB pathways. Biochem. Biophys. Res. Commun. 396, 978-982.
18. Lutter, D., Marr, C., Krumsiek, J., Lang, E. W., Theis, F. J., et al. (2010) Intronic microRNAs support their host genes by mediating synergistic and antagonistic regulatory effects. BMC Genomics 11, 224-235.
19. Baskerville, S., and, Bartel, D.P., (2005) Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA 11, 241-247.
20. Ning, L., Williams, A. H., Kim, Y., McAnally, J., Bezprozvannaya, S., et al. (2007) An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133. Proc. Natl. Acad. Sci. USA 104, 20844-20849.
21. Kim, Y.K., and, Kim, V.N., (2007) Processing of intronic microRNAs. EMBO J. 26, 775-783.
22. Ruby, J. G., Jan, C. H., and, Bartel, D. P., (2007) Intronic microRNA precursors that bypass Drosha processing. Nature 448, 83-86.
23. Havens, M. A., Reich, A. A., Duelli, D. M., and, Hastings, M. L., (2012) Biogenesis of mammalian microRNAs by a non-canonical processing pathway. Nucleic Acids Res. 40, 4626-4640.
24. Kuhnert, F., Mancuso, M. R., Hampton, J., Stankunas, K., Asano, T., et al. (2008) Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126. Development 135, 3989-3993.
25. Veronese, A., Lupini, L., Consiglio, J., Visone, R., Ferracin, M., et al. (2010) Oncogenic role of miR-483-3p at the IGF2/483 locus. Cancer Res. 70, 140-3149.
26. Veronese, A., Visone, R., Consiglio, J., Acunzo, M., Lupini, L., et al. (2011) Mutated beta-catenin evades a microRNA-dependent regulatory loop. Proc. Natl. Acad. Sci. USA 108, 4840-4845.
27. Qiao, Y., Ma, N., Wang, X., Hui, Y., Li, F., et al. (2011) MiR-483-5p controls angiogenesis in vitro and targets serum response factor. FEBS Lett. 585, 3095-3100.
28. Tran, V. G., Court, F., Duputié, A., Antoine, E., Aptel, N., et al. (2012) H19 antisense RNA can up-regulate igf2 transcription by activation of a novel promoter in mouse myoblasts. PLoS One 7, e37923.
29. Bell, M. L., Buvoli, M., and, Leinwand, L. A., (2010) Uncoupling of expression of an intronic microRNA and its myosin host gene by exon skipping. Mol. Cell Biol. 30, 1937-1945.
30. Cai, X., Hagedorn, C. H., and, Cullen, B. R., (2004) Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 10, 1957-1966.
31. Lee, K. H., Lotterman, C., Karikari, C., Omura, N., Feldmann, G., et al. (2009) Epigenetic silencing of MicroRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer. Pancreatology 9, 293-301.
32. Hinske, L. C. G., Galante, P. A. F., Kuo, W. P., and, Ohno-Machado, L., (2010) A potential role for intragenic miRNAs on their hosts' interactome. BMC Genomics 11, 533.
33. Kos, A., Olde Loohuis, N. F., Wieczorek, M. L., Glennon, J. C., Martens, G. J., et al. (2012) A potential regulatory role for intronic microRNA-338-3p for its host gene encoding apoptosis-associated tyrosine kinase. PLoS One 7, e31022.
34. Shi, W., Gerster, K., Alajez, N. M., Tsang, J., Waldron, L., et al. (2011) MicroRNA-301 mediates proliferation and invasion in human breast cancer. Cancer Res. 71, 2926-2937.
35. Rayner, K. J., Suárez, Y., Dávalos, A., Parathath, S., Fitzgerald, M. L., et al. (2010) MiR-33 contributes to the regulation of cholesterol homeostasis. Science 328, 1570-1573.
36. Rayner, K. J., Esau, C. C., Hussain, F. N., McDaniel, A. L., Marshall, S. M., et al. (2011) Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. Nature 478, 404-408.
37. van Rooij, E., Quiat, D., Johnson, B. A., Sutherland, L. B., Qi, X., et al. (2009) A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev. Cell. 17, 662-673.
38. Musiyenko, A., Bitko, V., and, Barik S., (2008) Ectopic expression of miR-126, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells. J. Mol. Med. (Berl.) 86, 313-322.
39. Barik, S., (2008) An intronic microRNA silences genes that are functionally antagonistic to its host gene. Nucleic Acids Res. 36, 5232-5241.
40. Ronchetti, D., Lionetti, M., Mosca, L., Agnelli, L., Andronache, A., et al. (2008) An integrative genomic approach reveals coordinated expression of intronic miR-335, miR-342, and miR-561 with deregulated host genes in multiple myeloma. BMC Med. Genomics 1, 37.
41. Poliseno, L., Tuccoli, A., Mariani, L., Evangelista, M., Citti, L., et al. (2006) MicroRNAs modulate the angiogenic properties of HUVECs. Blood 108, 3068-3071.
42. Ie Sage, C., Nagel, R., Egan, D. A., Schries, M., Mesman, E., et al. (2007) Regulaation of the p27 (Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation. EMBO J. 26, 3699-3708.
43. Ma, N., Li, F., Li, D., Hui, Y., Wang, X., et al. (2012) Igf2-derived intronic miR-483 promotes mouse hepatocellular carcinoma cell proliferation. Mol. Cell Biochem. 361, 337-343.
44. Tsang, W. P., Ng, E. K., Ng, S. S., Jin, H., Yu, J., et al. (2010) Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer. Carcinogenesis. 31, 350-358.
45. Keniry, A., Oxley, D., Monnier, P., Kyba, M., Dandolo, L., Smits G, Reik W,. (2012) The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r. Nat. Cell Biol. 14, 659-665.
46. Liu, J., Zhang, L., Wang, D., Shen, H., Jiang M, et al. (2003) Congenital diaphragmatic hernia, kidney agenesis and cardiac defects associated with Slit3-deficiency in mice. Mech Dev. 120, 1059-1070.
47. Osokine, I., Hsu, R., Loeb, G. B., and, McManus, M. T., (2008) Unintentional miRNA ablation is a risk factor in gene knockout studies: a short report. PLoS Genet. 4, e34.
48. He, C., Li, Z., Chen, P., Huang, H., Hurst, L. D., et al. (2012) Young intragenic miRNAs are less coexpressed with host genes than old ones: implications of miRNA-host gene coevolution. Nucleic Acids Res. 40, 4002-4012.
49. Smits, G., Mungall, A. J., Griffiths-Jones, S., Smith, P., Beury, D., et al. (2008) Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians. Nat. Genet. 40, 971-976.
50. Sikand, K., Slane, S. D., and, Shukla, G. C., (2009) Intrinsic expression of host genes and intronic miRNAs in prostate carcinoma cells. Cancer Cell Int. 9, 21-34.
51. Poliseno, L., Salmena, L., Riccardi, L., Fornari, A., Song, M. S., et al. (2010) dentification of the miR-106bâ 25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 intransformation. Sci. Signal. 3, ra29.
52. Saito, Y., Friedman, J. M., Chihara, Y., Egger, G., Chuang, J. C., et al. (2009) Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem. Biophys. Res. Commun. 379, 726-731.
53. Ding, J., Huang, S., Wu, S., Zhao, Y., Liang, L., et al. (2010) Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA. Nat. Cell Biol. 12, 390-399.
54. Levy, C., Khaled, M., Iliopoulos, D., Janas, M. M., and, Schubert, S., (2010) Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma. Mol. Cell. 40, 841-849.
55. Tie, J., Pan, Y., Zhao, L., Wu, K., Liu, J., et al. (2010) MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. PLoS Genet. 6, e1000879.
56. Zhu, Y., Kalbfleisch, T., Brennan, M. D., and, Li, Y., (2009) A microRNA gene is hosted in an intron of a schizophrenia-susceptibility gene. Schizophr. Res. 109, 86-89.