The enemy within: Intronic miR-26b represses its host gene, ctdsp2, to regulate neurogenesis

Genes and Development

Volumn 26, Issue 1, 2012, Pages 6-10

  Han, Jinju ^a   Denli, Ahmet M ^a   Gage, Fred H ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

ctdsp2; miR 26b; Neurogenesis; Neuronal differentiation; REST; Zebrafish

Indexed keywords

C TERMINAL DOMAIN SMALL PHOSPHATASE 2; MICRORNA; MICRORNA 26B; PHOSPHATASE; REPRESSOR ELEMENT 1 SILENCING TRANSCRIPTION FACTOR; RNA PRECURSOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; DOWN REGULATION; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; GENE REPRESSION; HUMAN; INTRON; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA TRANSCRIPTION;

ANIMALS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICRORNAS; NEURONS; PHOSPHOPROTEIN PHOSPHATASES; ZEBRAFISH PROTEINS;

DANIO RERIO;

EID: 84855317651     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.184416.111     Document Type: Article

References (37)

1. Ameres SL, Martinez J, Schroeder R. 2007. Molecular basis for target RNA recognition and cleavage by human RISC. Cell 130: 101-112.
2. Bahn S, Mimmack M, Ryan M, Caldwell MA, Jauniaux E, Starkey M, Svendsen CN, Emson P. 2002. Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: A gene expression study. Lancet 359: 310-315.
3. Ballas N, Grunseich C, Lu DD, Speh JC, Mandel G. 2005. REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell 121: 645-657.
4. Barik S. 2008. An intronic microRNA silences genes that are functionally antagonistic to its host gene. Nucleic Acids Res 36: 5232-5241.
5. Baskerville S, Bartel DP. 2005. Microarray profiling ofmicroRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA 11: 241-247.
6. Conaco C, Otto S, Han JJ, Mandel G. 2006. Reciprocal actions of REST and a microRNA promote neuronal identity. Proc Natl Acad Sci 103: 2422-2427.
7. Dill H, Linder B, Fehr A, Fischer U. 2012. Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2. Genes Dev (this issue). doi: 10.1101/gad. 177774.111.
8. Heo I, Joo C, Cho J, Ha M, Han J, Kim VN. 2008. Lin28 mediates the terminal uridylation of let-7 precursor microRNA. Mol Cell 32: 276-284.
9. Heo I, Joo C, Kim YK, Ha M, Yoon MJ, Cho J, Yeom KH, Han J, Kim VN. 2009. TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell 138: 696-708.
10. Hwang HW, Wentzel EA, Mendell JT. 2007. A hexanucleotide element directs microRNA nuclear import. Science 315: 97-100.
11. Jones SW, Watkins G, Le Good N, Roberts S, Murphy CL, Brockbank SM, Needham MR, Read SJ, Newham P. 2009. The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-a and MMP13. Osteoarthritis Cartilage 17: 464-472.
12. Katoh T, Sakaguchi Y, Miyauchi K, Suzuki T, Kashiwabara S, Baba T, Suzuki T. 2009. Selective stabilization of mammalian microRNAs by 39 adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2. Genes Dev 23: 433-438.
13. Kertesz M, Iovino N, Unnerstall U, Gaul U, Segal E. 2007. The role of site accessibility in microRNA target recognition. Nat Genet 39: 1278-1284.
14. Kim YK, Kim VN. 2007. Processing of intronic microRNAs. EMBO J 26: 775-783.
15. Kim VN, Han J, Siomi MC. 2009. Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol 10: 126-139.
16. Kim H, Huang W, Jiang X, Pennicooke B, Park PJ, Johnson MD. 2010. Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship. Proc Natl Acad Sci 107: 2183-2188.
17. Krol J, Busskamp V, Markiewicz I, Stadler MB, Ribi S, Richter J, Duebel J, Bicker S, Fehling HJ, Schubeler D, et al. 2010. Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs. Cell 141: 618-631.
18. Lee EJ, Baek M, Gusev Y, Brackett DJ, Nuovo GJ, Schmittgen TD. 2008. Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors. RNA 14: 35-42.
19. Lunyak VV, Rosenfeld MG. 2005. No rest for REST: REST/NRSF regulation of neurogenesis. Cell 121: 499-501.
20. Lutter D, Marr C, Krumsiek J, Lang EW, Theis FJ. 2010. Intronic microRNAs support their host genes by mediating synergistic and antagonistic regulatory effects. BMC Genomics 11: 224. doi: 10.1186/1471-2164-11-224.
21. Majumder S. 2006. REST in good times and bad: Roles in tumor suppressor and oncogenic activities. Cell Cycle 5: 1929-1935.
22. Newman MA, Thomson JM, Hammond SM. 2008. Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA 14: 1539-1549.
23. Ooi L, Wood IC. 2007. Chromatin crosstalk in development and disease: Lessons from REST. Nat Rev Genet 8: 544-554.
24. Rodriguez A, Griffiths-Jones S, Ashurst JL, Bradley A. 2004. Identification of mammalian microRNA host genes and transcription units. Genome Res 14: 1902-1910.
25. Schoenherr CJ, Anderson DJ. 1995. Silencing is golden: Negative regulation in the control of neuronal gene transcription. Curr Opin Neurobiol 5: 566-571.
26. Siomi H, Siomi MC. 2010. Posttranscriptional regulation of microRNA biogenesis in animals. Mol Cell 38: 323-332.
27. Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, et al. 2004. Human embryonic stem cells express a unique set of microRNAs. Dev Biol 270: 488-498.
28. Thompson J, Lepikhova T, Teixido-Travesa N, Whitehead MA, Palvimo JJ, Janne OA. 2006. Small carboxyl-terminal domain phosphatase 2 attenuates androgen-dependent transcription. EMBO J 25: 2757-2767.
29. Thomson JM, Newman M, Parker JS, Morin-Kensicki EM, Wright T, Hammond SM. 2006. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev 20: 2202-2207.
30. Trabucchi M, Briata P, Garcia-Mayoral M, Haase AD, Filipowicz W, Ramos A, Gherzi R, Rosenfeld MG. 2009. The RNAbinding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature 459: 1010-1014.
31. Visvanathan J, Lee S, Lee B, Lee JW, Lee SK. 2007. The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. Genes Dev 21: 744-749.
32. Viswanathan SR, Daley GQ, Gregory RI. 2008. Selective blockade of microRNA processing by Lin28. Science 320: 97-100.
33. Wrighton KH, Willis D, Long J, Liu F, Lin X, Feng XH. 2006. Small C-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance transforming growth factor-b signaling. J Biol Chem 281: 38365-38375.
34. Yeo M, Lee SK, Lee B, Ruiz EC, Pfaff SL, Gill GN. 2005. Small CTD phosphatases function in silencing neuronal gene expression. Science 307: 596-600.
35. Zhou D, Li S, Wen J, Gong X, Xu L, Luo Y. 2008. Genome-wide computational analyses of microRNAs and their targets from Canis familiaris. Comput Biol Chem 32: 60-65.
36. Zohn IE, Brivanlou AH. 2001. Expression cloning of Xenopus Os4, an evolutionarily conserved gene, which induces mesoderm and dorsal axis. Dev Biol 239: 118-131.
37. Zuccato C, Tartari M, Crotti A, Goffredo D, Valenza M, Conti L, Cataudella T, Leavitt BR, Hayden MR, Timmusk T, et al. 2003. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nat Genet 35: 76-83.