4-1BB Signaling Breaks the Tolerance of Maternal CD8+ T Cells That Are Reactive with Alloantigens

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Kim, Kwang H ^a   Choi, Beom K ^a   Kim, Jung D ^b   Kim, Young H ^a   Lee, Sun K ^c   Suh, Jae H ^d   Lee, Sang C ^a   Kang, Sang W ^c   Kwon, Byoung S ^a,e  

^a National Cancer Center   (South Korea)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c University of Ulsan   (South Korea)

^d University of Ulsan College of Medicine   (South Korea)

^e TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 1BBL ANTIGEN ANTIBODY; ALLOANTIGEN; CD137 ANTIGEN; CD137 ANTIGEN ANTIBODY; CD4 ANTIBODY; COMPLEMENT COMPONENT C3; IMMUNOGLOBULIN G; INDOLEAMINE 2,3 DIOXYGENASE; MONOCLONAL ANTIBODY; OKT 8; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ANTIGEN RECOGNITION; ARTICLE; BACTERIAL IMMUNITY; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; FEMALE; FETUS; FETUS RISK; FETUS WASTAGE; IMMUNOLOGICAL TOLERANCE; LISTERIOSIS; MOUSE; NONHUMAN; PLACENTA; PREGNANCY; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD137; AUTOANTIBODIES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; FETUS; IMMUNE TOLERANCE; ISOANTIGENS; LISTERIA MONOCYTOGENES; LISTERIOSIS; MALE; MICE; PLACENTA; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; SIGNAL TRANSDUCTION;

LISTERIA MONOCYTOGENES; MUS;

EID: 84866673871     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045481     Document Type: Article

References (32)

1. Trowsdale J, Betz AG, (2006) Mother's little helpers: mechanisms of maternal-fetal tolerance. Nat Immunol 7: 241-246.
2. Mellor AL, Sivakumar J, Chandler P, Smith K, Molina H, et al. (2001) Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy. Nat Immunol 2: 64-68.
3. Hayaishi O, Hirata F, Ohnishi T, Henry JP, Rosenthal I, et al. (1977) Indoleamine 2,3-dioxygenase: incorporation of 18O2- and 18O2 into the reaction products. J Biol Che 252: 3548-3550.
4. Melero I, Shuford WW, Newby SA, Aruffo A, Ledbetter JA, et al. (1997) Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med 3: 682-685.
5. Kwon BS, Weissman SM, (1989) cDNA sequences of two inducible T-cell genes. Proc Natl Acad Sci U S A 86: 1963-1967.
6. Pollok KE, Kim YJ, Zhou Z, Hurtado J, Kim KK, et al. (1993) Inducible T cell antigen 4-1BB. Analysis of expression and function. J Immunol 150: 771-781.
7. Vinay DS, Cha K, Kwon BS, (2006) Dual immunoregulatory pathways of 4-1BB signaling. J Mol Med 84: 726-736.
8. Halstead ES, Mueller YM, Altman JD, Katsikis PD, (2002) In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses. Nat Immunol 3: 536-541.
9. Larsen CP, Knechtle SJ, Adams A, Pearson T, Kirk AD, (2006) A New Look at Blockade of T-cell Costimulation: A Therapeutic Strategy for Long-term Maintenance of Immunosuppression. Am J Transplant 6: 876-883.
10. Yoshimatsu J, Matsumoto H, Narahara H, (2006) Co-stimulatory molecule OX40 ligand in early human pregnancy. Int J Gynaecol Obstet 93: 240-241.
11. Vacchio MS, Hodes RJ, (2007) CD28 costimulation is required for in vivo induction of peripheral tolerance in CD8+ T cells. J Exp Med 26: 19-26.
12. Phillips TA, Ni J, Hunt JS, (2001) Death-Inducing Tumour Necrosis Factor (TNF) superfamily ligands and Receptors are Transcribed in human placentae, cytotrophoblasts, Placental Macrophages and Placental Cell Lines. Placenta 22: 663-672.
13. Eckstrum K, Bany BM, (2011) Tumor necrosis factor receptor subfamily 9 (Tnfrsf9) gene is expressed in distinct cell populations in mouse uterus and conceptus during implantation period of pregnancy. Cell Tissue Res 344: 567-576.
14. Girardi G, Salmon JB, (2003) The role of complement in pregnancy and fetal loss. Autoimmunity 36: 19-26.
15. Xu C, Mao D, Holers VM, Palanca B, Cheng AM, et al. (2000) A critical role for murine complement regulator crry in fetomaternal tolerance. Science 287: 498-501.
16. Luft BJ, Remington JS, (1982) Effect of pregnancy on resistance to Listeria monocytogenes and Toxoplasma gondii infections in mice. Infect Immun 38: 1164-1171.
17. Constantin CM, Masopust D, Gourley T, Grayson J, Strickland OL, et al. (2007) Normal establishment of virus-specific memory CD8 T cell pool following primary infection during pregnancy. J Immunol 179: 4383-4389.
18. Seo SK, Choi JH, Kim YH, Kang WJ, Park HY, et al. (2004) 4-1BB-mediated immunotherapy of rheumatoid arthritis. Nat Med 10: 1088-1094.
19. Shuford WW, Klussman K, Tritchler DD, Loo DT, Chalupny J, et al. (2007) 4-1BB costimulation signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med 26: 47-55.
20. Sun Y, Lin X, Chen HM, Wu Q, Subudhi SK, et al. (2002) Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis. J Immunol 168: 1457-1465.
21. Choi BK, Asai T, Vinay DS, Kim YH, Kwon BS, (2006) 4-1BB-mediated amelioration of experimental autoimmune uveoretinitis is caused by indoleamine 2, 3-dioxygenase-dependent mechanisms. Cytokine 34: 233-242.
22. Myers L, Takahashi C, Mittler RS, Rossi RJ, Vella AT, (2003) Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering. Proc Natl Acad Sci U S A 100: 5348-5353.
23. Raghupathy R, (2001) Pregnancy: success and failure within the Th1/Th2/Th3 paradigm. Semin Immunol. 13: 219-227.
24. Mittler RS, Bailey TS, Klussman K, Trailsmith MD, Hoffmann MK, (1999) Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy. J Exp Med 190: 1535-1540.
25. Polte T, Foell J, Werner C, Hoymann HG, Braun A, et al. (2006) CD137-mediated immunotherapy for allergic asthma. J Clin Invest 116: 1025-1036.
26. Hellstrom KE, Hellstrom I, (2003) Therapeutic vaccination with tumor cells that engage CD137. Mol Med 81: 71-86.
27. Joachim RA, Hildebrandt M, Oder J, Klapp BF, Arck PC, (2001) Murine stress-triggered abortion is mediated by increase of CD8+ TNF-alpha+ decidual cells via substance P. Am J Reprod Immunol. 45: 303-309.
28. Makhseed M, Raghupathy R, Azizieh F, Omu A, Al-Shamali E, et al. (2001) Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions. Hum Reprod 16: 2219-2226.
29. Schwarz H (2006) Significance of reverse signal transduction for the biology of the CD137 receptor/lignad system. In: Chen L, editor. CD137 Pathway. Springer: New York. 29-45.
30. Kim JD, Kim CH, Kwon BS, (2011) Regulation of mouse 4-1BB expression: multiple promoter usages and a splice variant. Mol Cells 31: 141-149.
31. Wilcox RA, Tamada K, Flies DB, Zhu G, Chapoval AI, et al. (2004) Ligation of CD137 receptor prevents and reverses established anergy of CD8+ cytolytic T lymphocytes in vivo. Blood 103: 177-184.
32. Kwon BS, Hurtado JC, Lee ZH, Kwack KB, Seo SK, et al. (2002) Immune responses in 4-1BB (CD137)-deficient mice. J Immunol 168: 5483-5490.