Irrelevance of Microsatellite Instability in the Epidemiology of Sporadic Pancreatic Ductal Adenocarcinoma

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Laghi, Luigi ^a   Beghelli, Stefania ^b   Spinelli, Antonino ^a   Bianchi, Paolo ^a   Basso, Gianluca ^a,c   Di Caro, Giuseppe ^a,c   Brecht, Anna ^d   Celesti, Giuseppe ^a   Turri, Giona ^b   Bersani, Samantha ^b   Schumacher, Guido ^d   Röcken, Christoph ^d   Gräntzdörffer, Ilona ^d   Roncalli, Massimo ^a,c   Zerbi, Alessandro ^a   Neuhaus, Peter ^d   Bassi, Claudio ^e   Montorsi, Marco ^a,c   Scarpa, Aldo ^b   Malesci, Alberto ^a,c  

^a HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d HUMBOLDT UNIVERSITY   (Germany)

^e UNIVERSITY HOSPITAL OF VERONA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MLH1;

ADULT; AGED; ARTICLE; BAT25 GENE; BAT26 GENE; CANCER EPIDEMIOLOGY; CONTROLLED STUDY; FAMILY RELATION; FEMALE; GENE; GENE MUTATION; GENETIC SCREENING; GERM LINE; GERMANY; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; ITALY; LIFE HISTORY; MAJOR CLINICAL STUDY; MALE; METHYLATION; MICROSATELLITE INSTABILITY; MONONUCLEOTIDE REPEAT; NR 21 GENE; NR 24 GENE; NR 27 GENE; NUCLEOTIDE REPEAT; PANCREAS ADENOCARCINOMA; PANCREAS RESECTION; PREVALENCE; PROTEIN DEPLETION; RETROSPECTIVE STUDY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGED; CARCINOMA, PANCREATIC DUCTAL; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA MISMATCH REPAIR; FEMALE; HUMANS; MALE; METHYLATION; MICROSATELLITE INSTABILITY; MIDDLE AGED; NUCLEAR PROTEINS; PANCREAS; PANCREATIC NEOPLASMS; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84866662081     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046002     Document Type: Article

References (40)

1. Katz MH, Hwang R, Fleming JB, Evans DB, (2008) Tumor-node-metastasis staging of pancreatic adenocarcinoma. CA Cancer J Clin 58: 111-125.
2. Hidalgo M, (2010) Pancreatic cancer. N Engl J Med 362(1996); 1978:1986-1990.1996;1605-1917.
3. Grover S, Syngal S, (2010) Hereditary pancreatic cancer. Gastroenterology 139: 1076-1080, 1080 e1071-1072.
4. Laghi L, Bianchi P, Malesci A, (2008) Differences and evolution of the methods for the assessment of microsatellite instability. Oncogene 27: 6313-6321.
5. Malesci A, Laghi L, Bianchi P, Delconte G, Randolph A, et al. (2007) Reduced likelihood of metastases in patients with microsatellite-unstable colorectal cancer. Clin Cancer Res 13: 3831-3839.
6. Alexander J, Watanabe T, Wu TT, Rashid A, Li S, et al. (2001) Histopathological identification of colon cancer with microsatellite instability. Am J Pathol 158: 527-535.
7. Halling KC, Harper J, Moskaluk CA, Thibodeau SN, Petroni GR, et al. (1999) Origin of microsatellite instability in gastric cancer. Am J Pathol 155: 205-211.
8. Murphy MA, Wentzensen N, (2010) Frequency of mismatch repair deficiency in ovarian cancer: A systematic review. Int J Cancer.
9. DiMagno EP, Reber HA, Tempero MA, (1999) AGA technical review on the epidemiology, diagnosis, and treatment of pancreatic ductal adenocarcinoma. American Gastroenterological Association. Gastroenterology 117: 1464-1484.
10. Carpelan-Holmstrom M, Nordling S, Pukkala E, Sankila R, Luttges J, et al. (2005) Does anyone survive pancreatic ductal adenocarcinoma? A nationwide study re-evaluating the data of the Finnish Cancer Registry. Gut 54: 385-387.
11. Nakata B, Wang YQ, Yashiro M, Nishioka N, Tanaka H, et al. (2002) Prognostic value of microsatellite instability in resectable pancreatic cancer. Clin Cancer Res 8: 2536-2540.
12. Yamamoto H, Itoh F, Nakamura H, Fukushima H, Sasaki S, et al. (2001) Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability. Cancer Res 61: 3139-3144.
13. Geary J, Sasieni P, Houlston R, Izatt L, Eeles R, et al. (2008) Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC). Fam Cancer 7: 163-172.
14. Kastrinos F, Mukherjee B, Tayob N, Wang F, Sparr J, et al. (2009) Risk of pancreatic cancer in families with Lynch syndrome. Jama 302: 1790-1795.
15. Goggins M, Offerhaus GJ, Hilgers W, Griffin CA, Shekher M, et al. (1998) Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+. Am J Pathol 152: 1501-1507.
16. Tomaszewska R, Okon K, Stachura J, (2003) Expression of the DNA mismatch repair proteins (hMLH1 and hMSH2) in infiltrating pancreatic cancer and its relation to some phenotypic features. Pol J Pathol 54: 31-37.
17. Ghimenti C, Tannergard P, Wahlberg S, Liu T, Giulianotti PG, et al. (1999) Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumours. Br J Cancer 80: 11-16.
18. Maple JT, Smyrk TC, Boardman LA, Johnson RA, Thibodeau SN, et al. (2005) Defective DNA mismatch repair in long-term (> or = 3 years) survivors with pancreatic cancer. Pancreatology 5: 220-227; discussion 227-228.
19. Wilentz RE, Goggins M, Redston M, Marcus VA, Adsay NV, et al. (2000) Genetic, immunohistochemical, and clinical features of medullary carcinoma of the pancreas: A newly described and characterized entity. Am J Pathol 156: 1641-1651.
20. Real FX, (2005) Pancreatic Ductal Adenocarcinoma: Microsatellite Instability, familial Cancer Syndromes, and Medullary Histology. Pancreatology 5: 227-228.
21. Boland CR, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, et al. (1998) A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 58: 5248-5257.
22. Perucho M, (1999) Correspondence re: C.R. Boland, et al., A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res., 58: 5248-5257, 1998. Cancer Res 59: 249-256.
23. Xicola RM, Llor X, Pons E, Castells A, Alenda C, et al. (2007) Performance of different microsatellite marker panels for detection of mismatch repair-deficient colorectal tumors. J Natl Cancer Inst 99: 244-252.
24. Percesepe A, Kristo P, Aaltonen LA, Ponz de Leon M, de la Chapelle A, et al. (1998) Mismatch repair genes and mononucleotide tracts as mutation targets in colorectal tumors with different degrees of microsatellite instability. Oncogene 17: 157-163.
25. Nardon E, Glavac D, Benhattar J, Groenen PJ, Hofler G, et al. (2010) A multicenter study to validate the reproducibility of MSI testing with a panel of 5 quasimonomorphic mononucleotide repeats. Diagn Mol Pathol 19: 236-242.
26. AGA (1999) American gastroenterological association medical position statement: epidemiology, diagnosis, and treatment of pancreatic ductal adenocarcinoma. Gastroenterology 117: 1463-1484.
27. Nagakawa T, Konishi I, Ueno K, Ohta T, Akiyama T, et al. (1991) Surgical treatment of pancreatic cancer. The Japanese experience. Int J Pancreatol 9: 135-143.
28. Nagakawa T, Nagamori M, Futakami F, Tsukioka Y, Kayahara M, et al. (1996) Results of extensive surgery for pancreatic carcinoma. Cancer 77: 640-645.
29. Onoyama H, Kamigaki T, Yamamoto M, Saitoh Y, (1992) [Treatment and present status of pancreatic cancer]. Gan To Kagaku Ryoho 19: 2304-2310.
30. Furukawa H, Okada S, Saisho H, Ariyama J, Karasawa E, et al. (1996) Clinicopathologic features of small pancreatic adenocarcinoma. A collective study. Cancer 78: 986-990.
31. Longnecker DS, Karagas MR, Tosteson TD, Mott LA, (2000) Racial differences in pancreatic cancer: comparison of survival and histologic types of pancreatic carcinoma in Asians, blacks, and whites in the United States. Pancreas 21: 338-343.
32. Zell JA, Rhee JM, Ziogas A, Lipkin SM, Anton-Culver H, (2007) Race, socioeconomic status, treatment, and survival time among pancreatic cancer cases in California. Cancer Epidemiol Biomarkers Prev 16: 546-552.
33. Banville N, Geraghty R, Fox E, Leahy DT, Green A, et al. (2006) Medullary carcinoma of the pancreas in a man with hereditary nonpolyposis colorectal cancer due to a mutation of the MSH2 mismatch repair gene. Hum Pathol 37: 1498-1502.
34. Calhoun ES, Jones JB, Ashfaq R, Adsay V, Baker SJ, et al. (2003) BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets. Am J Pathol 163: 1255-1260.
35. Immervoll H, Hoem D, Kugarajh K, Steine SJ, Molven A, (2006) Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: lack of mutations in the BRAF and EGFR genes. Virchows Arch 448: 788-796.
36. Ruemmele P, Dietmaier W, Terracciano L, Tornillo L, Bataille F, et al. (2009) Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions. Am J Surg Pathol 33: 691-704.
37. Suraweera N, Duval A, Reperant M, Vaury C, Furlan D, et al. (2002) Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR. Gastroenterology 123: 1804-1811.
38. Laghi L, Ranzani GN, Bianchi P, Mori A, Heinimann K, et al. (2002) Frameshift mutations of human gastrin receptor gene (hGARE) in gastrointestinal cancers with microsatellite instability. Lab Invest 82: 265-271.
39. Miranda E, Destro A, Malesci A, Balladore E, Bianchi P, et al. (2006) Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer. Br J Cancer 95: 1101-1107.
40. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB, (1996) Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 93: 9821-9826.