메뉴 건너뛰기




Volumn 40, Issue 5, 2012, Pages 1047-1051

The synaptic function of LRRK2

Author keywords

Drosophila; Leucine rich repeat kinase 2 (LRRK2); Microtubule dynamics; Mitochondrial transport; Neuromuscular junction; Synaptic growth

Indexed keywords

INITIATION FACTOR 4E; LEUCINE RICH REPEAT KINASE 2;

EID: 84866646876     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20120113     Document Type: Review
Times cited : (24)

References (22)
  • 1
    • 77953666105 scopus 로고    scopus 로고
    • Genetic animal models of Parkinson's disease
    • Dawson, T.M., Ko, H.S. and Dawson, V.L. (2010) Genetic animal models of Parkinson's disease. Neuron 66, 646-661
    • (2010) Neuron , vol.66 , pp. 646-661
    • Dawson, T.M.1    Ko, H.S.2    Dawson, V.L.3
  • 2
    • 66149135641 scopus 로고    scopus 로고
    • Drosophila models of neurodegenerative diseases
    • Lu, B. and Vogel, H. (2009) Drosophila models of neurodegenerative diseases. Annu. Rev. Pathol. 4, 315-342
    • (2009) Annu. Rev. Pathol. , vol.4 , pp. 315-342
    • Lu, B.1    Vogel, H.2
  • 3
    • 51949090816 scopus 로고    scopus 로고
    • Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
    • Imai, Y., Gehrke, S., Wang, H.Q., Takahashi, R., Hasegawa, K., Oota, E. and Lu, B. (2008) Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J. 27, 2432-2443
    • (2008) EMBO J. , vol.27 , pp. 2432-2443
    • Imai, Y.1    Gehrke, S.2    Wang, H.Q.3    Takahashi, R.4    Hasegawa, K.5    Oota, E.6    Lu, B.7
  • 6
    • 41549124987 scopus 로고    scopus 로고
    • Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons
    • Wang, D., Tang, B., Zhao, G., Pan, Q., Xia, K., Bodmer, R. and Zhang, Z. (2008) Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons. Mol. Neurodegener. 3, 3
    • (2008) Mol. Neurodegener. , vol.3 , pp. 3
    • Wang, D.1    Tang, B.2    Zhao, G.3    Pan, Q.4    Xia, K.5    Bodmer, R.6    Zhang, Z.7
  • 7
    • 78650389179 scopus 로고    scopus 로고
    • LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction
    • Lee, S., Liu, H.P., Lin, W.Y., Guo, H. and Lu, B. (2010) LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction. J. Neurosci. 30, 16959-16969
    • (2010) J. Neurosci. , vol.30 , pp. 16959-16969
    • Lee, S.1    Liu, H.P.2    Lin, W.Y.3    Guo, H.4    Lu, B.5
  • 9
    • 77649328234 scopus 로고    scopus 로고
    • The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation
    • Kumar, A., Greggio, E., Beilina, A., Kaganovich, A., Chan, D., Taymans, J.-M., Wolozin, B. and Cookson, M.R. (2010) The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation. PLoS ONE 5, e8730
    • (2010) PLoS ONE , vol.5
    • Kumar, A.1    Greggio, E.2    Beilina, A.3    Kaganovich, A.4    Chan, D.5    Taymans, J.-M.6    Wolozin, B.7    Cookson, M.R.8
  • 10
    • 0034729749 scopus 로고    scopus 로고
    • Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions
    • Sigrist, S.J., Thiel, P.R., Reiff, D.F., Lachance, P.E., Lasko, P. and Schuster, C.M. (2000) Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions. Nature 405, 1062-1065
    • (2000) Nature , vol.405 , pp. 1062-1065
    • Sigrist, S.J.1    Thiel, P.R.2    Reiff, D.F.3    Lachance, P.E.4    Lasko, P.5    Schuster, C.M.6
  • 11
    • 8844253301 scopus 로고    scopus 로고
    • The translational repressor Pumilio regulates presynaptic morphology and controls postsynaptic accumulation of translation factor eIF-4E
    • Menon, K.P., Sanyal, S., Habara, Y., Sanchez, R., Wharton, R.P., Ramaswami, M. and Zinn, K. (2004) The translational repressor Pumilio regulates presynaptic morphology and controls postsynaptic accumulation of translation factor eIF-4E. Neuron 44, 663-676
    • (2004) Neuron , vol.44 , pp. 663-676
    • Menon, K.P.1    Sanyal, S.2    Habara, Y.3    Sanchez, R.4    Wharton, R.P.5    Ramaswami, M.6    Zinn, K.7
  • 12
    • 0032834055 scopus 로고    scopus 로고
    • EIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
    • Gingras, A.C., Raught, B. and Sonenberg, N. (1999) eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu. Rev. Biochem. 68, 913-963
    • (1999) Annu. Rev. Biochem. , vol.68 , pp. 913-963
    • Gingras, A.C.1    Raught, B.2    Sonenberg, N.3
  • 13
    • 77955152366 scopus 로고    scopus 로고
    • Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
    • Gehrke, S., Imai, Y., Sokol, N. and Lu, B. (2010) Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. Nature 466, 637-641
    • (2010) Nature , vol.466 , pp. 637-641
    • Gehrke, S.1    Imai, Y.2    Sokol, N.3    Lu, B.4
  • 14
    • 0033602410 scopus 로고    scopus 로고
    • Balancing proliferation and apoptosis in vivo: The Goldilocks theory of E2F/DP action
    • Yamasaki, L. (1999) Balancing proliferation and apoptosis in vivo: the Goldilocks theory of E2F/DP action. Biochim. Biophys. Acta 1423, 9-15
    • (1999) Biochim. Biophys. Acta , vol.1423 , pp. 9-15
    • Yamasaki, L.1
  • 15
    • 0033710887 scopus 로고    scopus 로고
    • Drosophila Futsch regulates synaptic microtubule organization and is necessary for synaptic growth
    • Roos, J., Hummel, T., Ng, N., Klambt, C. and Davis, G.W. (2000) Drosophila Futsch regulates synaptic microtubule organization and is necessary for synaptic growth. Neuron 26, 371-382
    • (2000) Neuron , vol.26 , pp. 371-382
    • Roos, J.1    Hummel, T.2    Ng, N.3    Klambt, C.4    Davis, G.W.5
  • 16
    • 84855474847 scopus 로고    scopus 로고
    • Mitochondrial dynamics and mitophagy in Parkinson's disease: Disordered cellular power plant becomes a big deal in a major movement disorder
    • Imai, Y. and Lu, B. (2011) Mitochondrial dynamics and mitophagy in Parkinson's disease: disordered cellular power plant becomes a big deal in a major movement disorder. Curr. Opin. Neurobiol. 21, 935-941
    • (2011) Curr. Opin. Neurobiol. , vol.21 , pp. 935-941
    • Imai, Y.1    Lu, B.2
  • 19
    • 84859237566 scopus 로고    scopus 로고
    • Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria
    • Liu, S., Sawada, T., Lee, S., Yu, W., Silverio, G., Alapatt, P., Millan, I., Shen, A., Saxton, W., Kanao, T. et al. (2012) Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria. PLoS Genet. 8, e1002537
    • (2012) PLoS Genet. , vol.8
    • Liu, S.1    Sawada, T.2    Lee, S.3    Yu, W.4    Silverio, G.5    Alapatt, P.6    Millan, I.7    Shen, A.8    Saxton, W.9    Kanao, T.10
  • 20
    • 84856056846 scopus 로고    scopus 로고
    • Mitochondrial transport in neurons: Impact on synaptic homeostasis and neurodegeneration
    • Sheng, Z.H. and Cai, Q. (2012) Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration. Nat. Rev. Neurosci. 13, 77-93
    • (2012) Nat. Rev. Neurosci. , vol.13 , pp. 77-93
    • Sheng, Z.H.1    Cai, Q.2
  • 22
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • Narendra, D., Tanaka, A., Suen, D.F. and Youle, R.J. (2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 183, 795-803
    • (2008) J. Cell Biol. , vol.183 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3    Youle, R.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.