Glioblastoma Cell-Secreted Interleukin-8 Induces Brain Endothelial Cell Permeability via CXCR2

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Dwyer, Julie ^a,b,c   Hebda, Jagoda K ^a,b,c   Le Guelte, Armelle ^a,b,c   Galan Moya, Eva Maria ^a,b,c   Smith, Sherri S ^a,b,c   Azzi, Sandy ^a,b,c   Bidere, Nicolas ^d   Gavard, Julie ^a,b,c  

^a CNRS   (France)

^b INSERM   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d INSERM U1014   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR2; INTERLEUKIN 8; VASCULAR ENDOTHELIAL CADHERIN;

ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; ANTIBODY SCREENING; ARTICLE; BLOOD VESSEL PERMEABILITY; BRAIN BLOOD VESSEL; CELL JUNCTION; CELL MEMBRANE PERMEABILITY; CELLULAR SECRETION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG DESIGN; ENDOTHELIUM CELL; GLIOBLASTOMA; HOMEOSTASIS; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; SIGNAL TRANSDUCTION; TUMOR CELL; TUMOR REGRESSION;

BRAIN NEOPLASMS; CAPILLARY PERMEABILITY; CELL LINE, TUMOR; CULTURE MEDIA, CONDITIONED; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; INTERLEUKIN-8; RECEPTORS, INTERLEUKIN-8B;

EID: 84866644780     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045562     Document Type: Article

References (47)

1. Jain RK, di Tomaso E, Duda DG, Loeffler JS, Sorensen AG, et al. (2007) Angiogenesis in brain tumours. Nat Rev Neurosci 8: 610-622.
2. Plate KH, Breier G, Weich HA, Mennel HD, Risau W, (1994) Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms. Int J Cancer 59: 520-529.
3. Carmeliet P, Jain RK, (2011) Molecular mechanisms and clinical applications of angiogenesis. Nature 473: 298-307.
4. Calabrese C, Poppleton H, Kocak M, Hogg TL, Fuller C, et al. (2007) A perivascular niche for brain tumor stem cells. Cancer Cell 11: 69-82.
5. Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, et al. (2007) AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11: 83-95.
6. Galan-Moya EM, Le Guelte A, Lima Fernandes E, Thirant C, Dwyer J, et al. (2011) Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway. EMBO Rep 12: 470-476.
7. Le Guelte A, Dwyer J, Gavard J, (2011) Jumping the barrier: VE-cadherin, VEGF and other angiogenic modifiers in cancer. Biol Cell 103: 593-605.
8. Keunen O, Johansson M, Oudin A, Sanzey M, Rahim SA, et al. (2011) Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. Proc Natl Acad Sci U S A 108: 3749-3754.
9. Ahluwalia MS, Gladson CL, (2010) Progress on antiangiogenic therapy for patients with malignant glioma. J Oncol 2010: 689018.
10. Marcus HJ, Carpenter KL, Price SJ, Hutchinson PJ, (2010) In vivo assessment of high-grade glioma biochemistry using microdialysis: a study of energy-related molecules, growth factors and cytokines. J Neurooncol 97: 11-23.
11. Waugh DJ, Wilson C, (2008) The interleukin-8 pathway in cancer. Clin Cancer Res 14: 6735-6741.
12. Benoy IH, Salgado R, Van Dam P, Geboers K, Van Marck E, et al. (2004) Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival. Clin Cancer Res 10: 7157-7162.
13. Zhang H, Fu T, McGettigan S, Kumar S, Liu S, et al. (2011) IL8 and Cathepsin B as Melanoma Serum Biomarkers. Int J Mol Sci 12: 1505-1518.
14. Desbaillets I, Diserens AC, Tribolet N, Hamou MF, Van Meir EG, (1997) Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis. J Exp Med 186: 1201-1212.
15. Lai Y, Shen Y, Liu XH, Zhang Y, Zeng Y, et al. (2011) Interleukin-8 induces the endothelial cell migration through the activation of phosphoinositide 3-kinase-Rac1/RhoA pathway. Int J Biol Sci 7: 782-791.
16. Li A, Dubey S, Varney ML, Dave BJ, Singh RK, (2003) IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J Immunol 170: 3369-3376.
17. Heidemann J, Ogawa H, Dwinell MB, Rafiee P, Maaser C, et al. (2003) Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2. J Biol Chem 278: 8508-8515.
18. Matsuo Y, Ochi N, Sawai H, Yasuda A, Takahashi H, et al. (2009) CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer. Int J Cancer 124: 853-861.
19. Gavard J, Hou X, Qu Y, Masedunskas A, Martin D, et al. (2009) A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability. Mol Cell Biol 29: 2469-2480.
20. Petreaca ML, Yao M, Liu Y, Defea K, Martins-Green M, (2007) Transactivation of vascular endothelial growth factor receptor-2 by interleukin-8 (IL-8/CXCL8) is required for IL-8/CXCL8-induced endothelial permeability. Mol Biol Cell 18: 5014-5023.
21. Weksler BB, Subileau EA, Perriere N, Charneau P, Holloway K, et al. (2005) Blood-brain barrier-specific properties of a human adult brain endothelial cell line. FASEB J 19: 1872-1874.
22. Gavard J, Gutkind JS, (2006) VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin. Nat Cell Biol 8: 1223-1234.
23. Dwyer J, Le Guelte A, Galan Moya EM, Sumbal M, Carlotti A, et al. (2011) Remodeling of VE-cadherin junctions by the human herpes virus 8 G-protein coupled receptor. Oncogene 30: 190-200.
24. Galan-Moya EM, Le Guelte A, Fernandes EL, Thirant C, Dwyer J, et al. (2011) Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway. EMBO Rep 12: 470-476.
25. Galan Moya EM, Le Guelte A, Gavard J, (2009) PAKing up to the endothelium. Cell Signal 21: 1727-1737.
26. Roebuck KA, (1999) Regulation of interleukin-8 gene expression. J Interferon Cytokine Res 19: 429-438.
27. Bonavia R, Inda MM, Vandenberg S, Cheng SY, Nagane M, et al. (2011) EGFRvIII promotes glioma angiogenesis and growth through the NF-kappaB, interleukin-8 pathway. Oncogene. in press.
28. Niu J, Azfer A, Zhelyabovska O, Fatma S, Kolattukudy PE, (2008) Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a novel transcription factor, MCP-1-induced protein (MCPIP). J Biol Chem 283: 14542-14551.
29. Salcedo R, Ponce ML, Young HA, Wasserman K, Ward JM, et al. (2000) Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression. Blood 96: 34-40.
30. Ma J, Wang Q, Fei T, Han JD, Chen YG, (2007) MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood 109: 987-994.
31. Waugh DJJ, Wilson C, (2008) The Interleukin-8 Pathway in Cancer. Clin Cancer Res 14: 6735-6741.
32. Horuk R, (1994) The interleukin-8-receptor family: from chemokines to malaria. Immunol Today 15: 169-174.
33. Brat DJ, Bellail AC, Van Meir EG, (2005) The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol 7: 122-133.
34. Keane MP, Belperio JA, Xue YY, Burdick MD, Strieter RM, (2004) Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancer. J Immunol 172: 2853-2860.
35. Caunt M, Hu L, Tang T, Brooks PC, Ibrahim S, et al. (2006) Growth-regulated oncogene is pivotal in thrombin-induced angiogenesis. Cancer Res 66: 4125-4132.
36. Goede V, Brogelli L, Ziche M, Augustin HG, (1999) Induction of inflammatory angiogenesis by monocyte chemoattractant protein-1. Int J Cancer 82: 765-770.
37. Yamada M, Kim S, Egashira K, Takeya M, Ikeda T, et al. (2003) Molecular mechanism and role of endothelial monocyte chemoattractant protein-1 induction by vascular endothelial growth factor. Arterioscler Thromb Vasc Biol 23: 1996-2001.
38. Hong TM, Teng LJ, Shun CT, Peng MC, Tsai JC, (2009) Induced interleukin-8 expression in gliomas by tumor-associated macrophages. J Neurooncol 93: 289-301.
39. Singh S, Nannuru KC, Sadanandam A, Varney ML, Singh RK, (2009) CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion. Br J Cancer 100: 1638-1646.
40. Reardon DA, Turner S, Peters KB, Desjardins A, Gururangan S, et al. (2011) A review of VEGF/VEGFR-targeted therapeutics for recurrent glioblastoma. J Natl Compr Canc Netw 9: 414-427.
41. Martin D, Galisteo R, Gutkind JS, (2009) CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcl10/Malt1) complex. J Biol Chem 284: 6038-6042.
42. Mizukami Y, Fujiki K, Duerr EM, Gala M, Jo WS, et al. (2006) Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc. J Biol Chem 281: 13957-13963.
43. Michaud SE, Menard C, Guy LG, Gennaro G, Rivard A, (2003) Inhibition of hypoxia-induced angiogenesis by cigarette smoke exposure: impairment of the HIF-1alpha/VEGF pathway. FASEB J 17: 1150-1152.
44. Jensen RL, Ragel BT, Whang K, Gillespie D, (2006) Inhibition of hypoxia inducible factor-1alpha (HIF-1alpha) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas. J Neurooncol 78: 233-247.
45. Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG Jr, (2002) Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 1: 237-246.
46. Lu KV, Chang JP, Parachoniak CA, Pandika MM, Aghi MK, et al. (2012) VEGF Inhibits Tumor Cell Invasion and Mesenchymal Transition through a MET/VEGFR2 Complex. Cancer Cell 22: 21-35.
47. Huang D, Ding Y, Li Y, Luo WM, Zhang ZF, et al. (2010) Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma. Cancer Res 70: 1053-1062.