메뉴 건너뛰기




Volumn 32, Issue 5, 2012, Pages 250-256

PTHLH coupling upstream negative regulation of fatty acid biosynthesis and Wnt receptor signal to downstream peptidase activity-induced apoptosis network in human hepatocellular carcinoma by systems-theoretical analysis

Author keywords

Computation; The corresponding activated and inhibited GO network of no tumor hepatitis cirrhotic tissues; The corresponding inhibited GO network of HCC; The same PTHLH feedback negative regulation mediated apoptosis GO and molecular network of HCC

Indexed keywords

BRCA1 PROTEIN; FRIZZLED PROTEIN; P21 ACTIVATED KINASE; PEPTIDASE; UBIQUITIN;

EID: 84866630489     PISSN: 10799893     EISSN: 15324281     Source Type: Journal    
DOI: 10.3109/10799893.2012.700717     Document Type: Article
Times cited : (13)

References (38)
  • 2
    • 33746508998 scopus 로고    scopus 로고
    • Specific gene expression profiles distinguish among functional allelic variants of the mouse Pthlh gene in transfected human cancer cells
    • Gianni-Barrera R, Gariboldi M, De Cecco L, Manenti G, Dragani TA. Specific gene expression profiles distinguish among functional allelic variants of the mouse Pthlh gene in transfected human cancer cells. Oncogene 2006, 25, 4501-4504.
    • (2006) Oncogene , vol.25 , pp. 4501-4504
    • Gianni-Barrera, R.1    Gariboldi, M.2    De Cecco, L.3    Manenti, G.4    Dragani, T.A.5
  • 3
    • 0027976951 scopus 로고
    • Parathyroid hormone-like protein: Alternative messenger RNA splicing pathways in human cancer cell lines
    • Brandt DW, Wachsman W, Deftos LJ. Parathyroid hormone-like protein: alternative messenger RNA splicing pathways in human cancer cell lines. Cancer Res 1994, 54, 850-853.
    • (1994) Cancer Res , vol.54 , pp. 850-853
    • Brandt, D.W.1    Wachsman, W.2    Deftos, L.J.3
  • 5
    • 0027224015 scopus 로고
    • Parathyroid hormone-like protein is a secretory product of atrial myocytes
    • Deftos LJ, Burton DW, Brandt DW. Parathyroid hormone-like protein is a secretory product of atrial myocytes. J Clin Invest 1993, 92, 727-735.
    • (1993) J Clin Invest , vol.92 , pp. 727-735
    • Deftos, L.J.1    Burton, D.W.2    Brandt, D.W.3
  • 6
    • 0027209784 scopus 로고
    • Parathyroid hormone-like peptide and parathyroid hormone are secreted from bovine parathyroid via different pathways
    • Connor C, Drees B, Hamilton J. Parathyroid hormone-like peptide and parathyroid hormone are secreted from bovine parathyroid via different pathways. Biochim Biophys Acta 1993, 1178, 81-86.
    • (1993) Biochim Biophys Acta , vol.1178 , pp. 81-86
    • Connor, C.1    Drees, B.2    Hamilton, J.3
  • 7
    • 0026670490 scopus 로고
    • Parathyroid hormone-like peptide in pancreatic endocrine carcinoma and adenocarcinoma associated with hypercalcemia
    • Miraliakbari BA, Asa SL, Boudreau SF. Parathyroid hormone-like peptide in pancreatic endocrine carcinoma and adenocarcinoma associated with hypercalcemia. Hum Pathol 1992, 23, 884-887.
    • (1992) Hum Pathol , vol.23 , pp. 884-887
    • Miraliakbari, B.A.1    Asa, S.L.2    Boudreau, S.F.3
  • 8
    • 0025769120 scopus 로고
    • Bioactivity of parathyroid hormone and parathyroid hormone-like peptide: Agonist and antagonist activities of amino-terminal fragments as assessed by the cytochemical bioassay and in situ biochemistry
    • Loveridge N, Dean V, Goltzman D, Hendy GN. Bioactivity of parathyroid hormone and parathyroid hormone-like peptide: agonist and antagonist activities of amino-terminal fragments as assessed by the cytochemical bioassay and in situ biochemistry. Endocrinology 1991, 128, 1938-1946.
    • (1991) Endocrinology , vol.128 , pp. 1938-1946
    • Loveridge, N.1    Dean, V.2    Goltzman, D.3    Hendy, G.N.4
  • 9
    • 0025847993 scopus 로고
    • Immunological identification and distribution of parathyroid hormone-like protein polypeptides in normal and malignant tissues
    • Kramer S, Reynolds FH Jr, Castillo M, Valenzuela DM, Thorikay M, Sorvillo JM. Immunological identification and distribution of parathyroid hormone-like protein polypeptides in normal and malignant tissues. Endocrinology 1991, 128, 1927-1937.
    • (1991) Endocrinology , vol.128 , pp. 1927-1937
    • Kramer, S.1    Reynolds Jr., F.H.2    Castillo, M.3    Valenzuela, D.M.4    Thorikay, M.5    Sorvillo, J.M.6
  • 10
    • 0026331893 scopus 로고
    • Dysregulation of parathyroid hormone-like peptide expression and secretion in a keratinocyte model of tumor progression
    • Henderson J, Sebag M, Rhim J, Goltzman D, Kremer R. Dysregulation of parathyroid hormone-like peptide expression and secretion in a keratinocyte model of tumor progression. Cancer Res 1991, 51, 6521-6528.
    • (1991) Cancer Res , vol.51 , pp. 6521-6528
    • Henderson, J.1    Sebag, M.2    Rhim, J.3    Goltzman, D.4    Kremer, R.5
  • 11
    • 0025841675 scopus 로고
    • All major lung cancer cell types produce parathyroid hormonelike protein: Heterogeneity assessed by high performance liquid chromatography
    • Brandt DW, Burton DW, Gazdar AF, Oie HE, Deftos LJ. All major lung cancer cell types produce parathyroid hormonelike protein: heterogeneity assessed by high performance liquid chromatography. Endocrinology 1991, 129, 2466-2470.
    • (1991) Endocrinology , vol.129 , pp. 2466-2470
    • Brandt, D.W.1    Burton, D.W.2    Gazdar, A.F.3    Oie, H.E.4    Deftos, L.J.5
  • 12
    • 0025104103 scopus 로고
    • Parathyroid hormone-like peptide in normal and neoplastic mesothelial cells
    • McAuley P, Asa SL, Chiu B, Henderson J, Goltzman D, Drucker DJ. Parathyroid hormone-like peptide in normal and neoplastic mesothelial cells. Cancer 1990, 66, 1975-1979.
    • (1990) Cancer , vol.66 , pp. 1975-1979
    • McAuley, P.1    Asa, S.L.2    Chiu, B.3    Henderson, J.4    Goltzman, D.5    Drucker, D.J.6
  • 13
    • 0036020892 scopus 로고    scopus 로고
    • A direct approach to false discovery rates
    • Storey JD. A direct approach to false discovery rates. J Roy Stat Soc Ser B 2002, 64, 479-498.
    • (2002) J Roy Stat Soc ser B , vol.64 , pp. 479-498
    • Storey, J.D.1
  • 14
    • 33750016109 scopus 로고    scopus 로고
    • Inferring gene regulatory networks from multiple microarray datasets
    • Wang Y, Joshi T, Zhang XS, Xu D, Chen L. Inferring gene regulatory networks from multiple microarray datasets. Bioinformatics 2006, 22, 2413-2420.
    • (2006) Bioinformatics , vol.22 , pp. 2413-2420
    • Wang, Y.1    Joshi, T.2    Zhang, X.S.3    Xu, D.4    Chen, L.5
  • 15
    • 65649120068 scopus 로고    scopus 로고
    • Integrative decomposition procedure and Kappa statistics for the distinguished single molecular network construction and analysis
    • Wang L, Sun Y, Jiang M, Zheng X. Integrative decomposition procedure and Kappa statistics for the distinguished single molecular network construction and analysis. J Biomed Biotechnol 2009, 2009, 726728.
    • (2009) J Biomed Biotechnol , vol.2009 , pp. 726728
    • Wang, L.1    Sun, Y.2    Jiang, M.3    Zheng, X.4
  • 16
    • 70249107457 scopus 로고    scopus 로고
    • FOS proliferating network construction in early colorectal cancer (CRC) based on integrative significant function cluster and inferring analysis
    • Wang L, Sun Y, Jiang M, Zhang S, Wolfl S. FOS proliferating network construction in early colorectal cancer (CRC) based on integrative significant function cluster and inferring analysis. Cancer Invest 2009, 27, 816-824.
    • (2009) Cancer Invest , vol.27 , pp. 816-824
    • Wang, L.1    Sun, Y.2    Jiang, M.3    Zhang, S.4    Wolfl, S.5
  • 17
    • 79955448835 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor 3 (CDKN3) novel cell cycle computational network between human non-malignancy associated hepatitis/cirrhosis and hepatocellular carcinoma (HCC) transformation
    • Wang L, Sun L, Huang J, Jiang M. Cyclin-dependent kinase inhibitor 3 (CDKN3) novel cell cycle computational network between human non-malignancy associated hepatitis/cirrhosis and hepatocellular carcinoma (HCC) transformation. Cell Prolif 2011, 44, 291-299.
    • (2011) Cell Prolif , vol.44 , pp. 291-299
    • Wang, L.1    Sun, L.2    Huang, J.3    Jiang, M.4
  • 18
    • 78049499943 scopus 로고    scopus 로고
    • AFP computational secreted network construction and analysis between human hepatocellular carcinoma (HCC) and no-tumor hepatitis/cirrhotic liver tissues
    • Wang L, Huang J, Jiang M, Zheng X. AFP computational secreted network construction and analysis between human hepatocellular carcinoma (HCC) and no-tumor hepatitis/cirrhotic liver tissues. Tumour Biol 2011, 31, 417-425.
    • (2011) Tumour Biol , vol.31 , pp. 417-425
    • Wang, L.1    Huang, J.2    Jiang, M.3    Zheng, X.4
  • 19
    • 79959738235 scopus 로고    scopus 로고
    • MYBPC1 computational phosphoprotein network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients
    • Wang L, Huang J, Jiang M, Sun L. MYBPC1 computational phosphoprotein network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients. Cell Mol Neurobiol 2011, 31, 233-241.
    • (2011) Cell Mol Neurobiol , vol.31 , pp. 233-241
    • Wang, L.1    Huang, J.2    Jiang, M.3    Sun, L.4
  • 20
    • 79953713241 scopus 로고    scopus 로고
    • Survivin (BIRC5) cell cycle computational network in human no-tumor hepatitis/cirrhosis and hepatocellular carcinoma transformation
    • Wang L, Huang J, Jiang M, Sun L. Survivin (BIRC5) cell cycle computational network in human no-tumor hepatitis/cirrhosis and hepatocellular carcinoma transformation. J Cell Biochem 2011, 112, 1286-1294.
    • (2011) J Cell Biochem , vol.112 , pp. 1286-1294
    • Wang, L.1    Huang, J.2    Jiang, M.3    Sun, L.4
  • 21
    • 84863860561 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 2 (STAT2) metabolism coupling postmitotic outgrowth to visual and sound perception network in human left cerebrum by biocomputation
    • Wang L, Huang J, Jiang M, Lin H. Signal transducer and activator of transcription 2 (STAT2) metabolism coupling postmitotic outgrowth to visual and sound perception network in human left cerebrum by biocomputation. J Mol Neurosci 2012, 47, 649-658.
    • (2012) J Mol Neurosci , vol.47 , pp. 649-658
    • Wang, L.1    Huang, J.2    Jiang, M.3    Lin, H.4
  • 22
    • 78249290385 scopus 로고    scopus 로고
    • RRM2 computational phosphoprotein network construction and analysis between no-tumor hepatitis/ cirrhotic liver tissues and human hepatocellular carcinoma (HCC)
    • Wang L, Huang J, Jiang M. RRM2 computational phosphoprotein network construction and analysis between no-tumor hepatitis/ cirrhotic liver tissues and human hepatocellular carcinoma (HCC). Cell Physiol Biochem 2011, 26, 303-310.
    • (2011) Cell Physiol Biochem , vol.26 , pp. 303-310
    • Wang, L.1    Huang, J.2    Jiang, M.3
  • 23
    • 79958289421 scopus 로고    scopus 로고
    • CREB5 computational regulation network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients
    • Wang L, Huang J, Jiang M. CREB5 computational regulation network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients. Cell Biochem Biophys 2011, 60, 199-207.
    • (2011) Cell Biochem Biophys , vol.60 , pp. 199-207
    • Wang, L.1    Huang, J.2    Jiang, M.3
  • 24
    • 52949097246 scopus 로고    scopus 로고
    • Integrative decomposition procedure and Kappa statistics set up ATF2 ion binding module in malignant pleural mesothelioma (MPM)
    • Sun Y, Wang L, Lui L. Integrative decomposition procedure and Kappa statistics set up ATF2 ion binding module in malignant pleural mesothelioma (MPM). Front Electr Electron Eng China 2008, 3, 381-387.
    • (2008) Front Electr Electron Eng China , vol.3 , pp. 381-387
    • Sun, Y.1    Wang, L.2    Lui, L.3
  • 25
    • 77951295803 scopus 로고    scopus 로고
    • Secreted phosphoprotein 1 upstream invasive network construction and analysis of lung adenocarcinoma compared with human normal adjacent tissues by integrative biocomputation
    • Sun Y, Wang L, Jiang M, Huang J, Liu Z, Wolfl S. Secreted phosphoprotein 1 upstream invasive network construction and analysis of lung adenocarcinoma compared with human normal adjacent tissues by integrative biocomputation. Cell Biochem Biophys 2010, 56, 59-71.
    • (2010) Cell Biochem Biophys , vol.56 , pp. 59-71
    • Sun, Y.1    Wang, L.2    Jiang, M.3    Huang, J.4    Liu, Z.5    Wolfl, S.6
  • 26
    • 81155131172 scopus 로고    scopus 로고
    • Glycogen debranching enzyme 6 (AGL), enolase 1 (ENOSF1), ectonucleotide pyrophosphatase 2 (ENPP2-1), glutathione S-transferase 3 (GSTM3-3) and mannosidase (MAN2B2) metabolism computational network analysis between chimpanzee and human left cerebrum
    • Sun L, Wang L, Jiang M, Huang J, Lin H. Glycogen debranching enzyme 6 (AGL), enolase 1 (ENOSF1), ectonucleotide pyrophosphatase 2 (ENPP2-1), glutathione S-transferase 3 (GSTM3-3) and mannosidase (MAN2B2) metabolism computational network analysis between chimpanzee and human left cerebrum. Cell Biochem Biophys 2011, 61, 493-505.
    • (2011) Cell Biochem Biophys , vol.61 , pp. 493-505
    • Sun, L.1    Wang, L.2    Jiang, M.3    Huang, J.4    Lin, H.5
  • 27
    • 77957200673 scopus 로고    scopus 로고
    • TNFRSF11B computational development network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients
    • Huang JX, Wang L, Jiang MH. TNFRSF11B computational development network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients. J Inflamm (Lond) 2011, 7, 50.
    • (2011) J Inflamm (Lond) , vol.7 , pp. 50
    • Huang, J.X.1    Wang, L.2    Jiang, M.H.3
  • 28
    • 85065054069 scopus 로고    scopus 로고
    • Interferon α-inducible protein 27 computational network construction and comparison between the frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients
    • Huang J, Wang L, Jiang M, Zheng X. Interferon α-inducible protein 27 computational network construction and comparison between the frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients. Open Genomics J 2010, 3, 1-8.
    • (2010) Open Genomics J , vol.3 , pp. 1-8
    • Huang, J.1    Wang, L.2    Jiang, M.3    Zheng, X.4
  • 29
    • 79951824368 scopus 로고    scopus 로고
    • Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling
    • Doubravska L, Krausova M, Gradl D, Vojtechova M, Tumova L, Lukas J, Valenta T, et al. Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling. Cell Signal 2012, 23, 837-848.
    • (2012) Cell Signal , vol.23 , pp. 837-848
    • Doubravska, L.1    Krausova, M.2    Gradl, D.3    Vojtechova, M.4    Tumova, L.5    Lukas, J.6    Valenta, T.7
  • 31
    • 58649104220 scopus 로고    scopus 로고
    • LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling
    • Terrand J, Bruban V, Zhou L, Gong W, El Asmar Z, May P, Zurhove K, et al. LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling. J Biol Chem 2009, 284, 381-388.
    • (2009) J Biol Chem , vol.284 , pp. 381-388
    • Terrand, J.1    Bruban, V.2    Zhou, L.3    Gong, W.4    El Asmar, Z.5    May, P.6    Zurhove, K.7
  • 32
    • 75349102009 scopus 로고    scopus 로고
    • The adenomatous polyposis coli tumor suppressor and Wnt signaling in the regulation of apoptosis
    • Benchabane H, Ahmed Y. The adenomatous polyposis coli tumor suppressor and Wnt signaling in the regulation of apoptosis. Adv Exp Med Biol 2009, 656, 75-84.
    • (2009) Adv Exp Med Biol , vol.656 , pp. 75-84
    • Benchabane, H.1    Ahmed, Y.2
  • 33
    • 0035027705 scopus 로고    scopus 로고
    • Effects of an inhibitor of tripeptidyl peptidase II (Ala-Ala- Phechloromethylketone) and its combination with an inhibitor of the chymotrypsin-like activity of the proteasome (PSI) on apoptosis, cell cycle and proteasome activity in U937 cells
    • Bury M, Mlynarczuk I, Pleban E, Hoser G, Kawiak J, Wójcik C. Effects of an inhibitor of tripeptidyl peptidase II (Ala-Ala- Phechloromethylketone) and its combination with an inhibitor of the chymotrypsin-like activity of the proteasome (PSI) on apoptosis, cell cycle and proteasome activity in U937 cells. Folia Histochem Cytobiol 2001, 39, 131-132.
    • (2001) Folia Histochem Cytobiol , vol.39 , pp. 131-132
    • Bury, M.1    Mlynarczuk, I.2    Pleban, E.3    Hoser, G.4    Kawiak, J.5    Wójcik, C.6
  • 34
    • 79951986031 scopus 로고    scopus 로고
    • Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma
    • Hirata H, Hinoda Y, Nakajima K, Kawamoto K, Kikuno N, Ueno K, Yamamura S, et al. Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma. Int J Cancer 2012, 128, 1793-1803.
    • (2012) Int J Cancer , vol.128 , pp. 1793-1803
    • Hirata, H.1    Hinoda, Y.2    Nakajima, K.3    Kawamoto, K.4    Kikuno, N.5    Ueno, K.6    Yamamura, S.7
  • 35
    • 84861660394 scopus 로고    scopus 로고
    • Wnt inhibitory factor 1 induces apoptosis and inhibits cervical cancer growth, invasion and angiogenesis in vivo
    • Ramachandran I, Thavathiru E, Ramalingam S, Natarajan G, Mills WK, Benbrook DM, Zuna R, et al. Wnt inhibitory factor 1 induces apoptosis and inhibits cervical cancer growth, invasion and angiogenesis in vivo. Oncogene 2012, 31, 2725-2737.
    • (2012) Oncogene , vol.31 , pp. 2725-2737
    • Ramachandran, I.1    Thavathiru, E.2    Ramalingam, S.3    Natarajan, G.4    Mills, W.K.5    Benbrook, D.M.6    Zuna, R.7
  • 36
    • 34548079518 scopus 로고    scopus 로고
    • Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells
    • Shi Y, He B, Kuchenbecker KM, You L, Xu Z, Mikami I, Yagui- Beltran A, et al. Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells. Int J Cancer 2007, 121, 1175-1181.
    • (2007) Int J Cancer , vol.121 , pp. 1175-1181
    • Shi, Y.1    He, B.2    Kuchenbecker, K.M.3    You, L.4    Xu, Z.5    Mikami, I.6    Yagui- Beltran, A.7
  • 37
    • 0036106013 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling suppresses apoptosis in low serum medium and induces morphologic change in rodent fibroblasts
    • Ueda Y, Hijikata M, Takagi S, Takada R, Takada S, Chiba T, Shimotohno K. Wnt/beta-catenin signaling suppresses apoptosis in low serum medium and induces morphologic change in rodent fibroblasts. Int J Cancer 2002, 99, 681-688.
    • (2002) Int J Cancer , vol.99 , pp. 681-688
    • Ueda, Y.1    Hijikata, M.2    Takagi, S.3    Takada, R.4    Takada, S.5    Chiba, T.6    Shimotohno, K.7
  • 38
    • 30944433183 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling inhibits death receptor-mediated apoptosis and promotes invasive growth of HNSCC
    • Yang F, Zeng Q, Yu G, Li S, Wang CY. Wnt/beta-catenin signaling inhibits death receptor-mediated apoptosis and promotes invasive growth of HNSCC. Cell Signal 2006, 18, 679-687.
    • (2006) Cell Signal , vol.18 , pp. 679-687
    • Yang, F.1    Zeng, Q.2    Yu, G.3    Li, S.4    Wang, C.Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.