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Volumn 92, Issue 4, 2012, Pages 476-485

Personalizing antiplatelet therapy with clopidogrel

Author keywords

[No Author keywords available]

Indexed keywords

ARYLDIALKYLPHOSPHATASE 1; CILOSTAZOL; CLOPIDOGREL; CYTOCHROME P450; MULTIDRUG RESISTANCE PROTEIN 1; PRASUGREL; TICAGRELOR; TICLOPIDINE;

EID: 84866618180     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2012.133     Document Type: Article
Times cited : (15)

References (78)
  • 1
    • 9244251971 scopus 로고    scopus 로고
    • A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents
    • Schömig, A. et al. A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents. N. Engl. J. Med. 334, 1084-1089 (1996).
    • (1996) N. Engl. J. Med. , vol.334 , pp. 1084-1089
    • Schömig, A.1
  • 2
    • 0034622539 scopus 로고    scopus 로고
    • Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting: The clopidogrel aspirin stent international cooperative study (cLASSIcS)
    • cLASSIcS Investigators
    • Bertrand, M.E., Rupprecht, H.J., Urban, P. & Gershlick, A.H.; cLASSIcS Investigators. Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting: the clopidogrel aspirin stent international cooperative study (cLASSIcS). Circulation 102, 624-629 (2000).
    • (2000) Circulation , vol.102 , pp. 624-629
    • Bertrand, M.E.1    Rupprecht, H.J.2    Urban, P.3    Gershlick, A.H.4
  • 3
    • 20144373281 scopus 로고    scopus 로고
    • Addition of clopidogrel to aspirin and fbrinolytic therapy for myocardial infarction with St-segment elevation
    • Sabatine, M.S. et al. Addition of clopidogrel to aspirin and fbrinolytic therapy for myocardial infarction with St-segment elevation. N. Engl. J. Med. 352, 1179-1189 (2005).
    • (2005) N. Engl. J. Med. , vol.352 , pp. 1179-1189
    • Sabatine, M.S.1
  • 4
    • 0035899289 scopus 로고    scopus 로고
    • Efects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without St-segment elevation
    • The clopidogrel in Unstable Angina to Prevent Recurrent Ischemic Events trial Investigators
    • The clopidogrel in Unstable Angina to Prevent Recurrent Ischemic Events trial Investigators. Efects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without St-segment elevation. N Engl J Med. 345, 494-502 (2001).
    • (2001) N Engl J Med. , vol.345 , pp. 494-502
  • 5
    • 29344457180 scopus 로고    scopus 로고
    • Acc/AHA/ScAI 2005 guideline update for percutaneous coronary intervention: A report of the American college of cardiology/American Heart Association task Force on Practice Guidelines (Acc/AHA/ScAI Writing committee to Update the 2001 Guidelines for Percutaneous coronary Intervention)
    • Smith, S.c. Jr et al. Acc/AHA/ScAI 2005 guideline update for percutaneous coronary intervention: a report of the American college of cardiology/American Heart Association task Force on Practice Guidelines (Acc/AHA/ScAI Writing committee to Update the 2001 Guidelines for Percutaneous coronary Intervention). J. Am. Coll. Cardiol. 47, e1-121 (2006).
    • (2006) J. Am. Coll. Cardiol. , vol.47
    • Smith Jr., S.C.1
  • 6
    • 34547655744 scopus 로고    scopus 로고
    • Acc/AHA 2007 guidelines for the management of patients with unstable angina/non-St-Elevation myocardial infarction
    • Anderson, J.L., et al. Acc/AHA 2007 guidelines for the management of patients with unstable angina/non-St-Elevation myocardial infarction: a report of the American college of cardiology/American Heart Association task Force on Practice Guidelines (Writing committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-St-Elevation Myocardial Infarction) developed in collaboration with the American college of Emergency Physicians, the Society for cardiovascular Angiography and Interventions, and the Society of thoracic Surgeons endorsed by the American Association of cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. J Am Coll Cardiol. 50, e1-e157 (2007).
    • (2007) J Am Coll Cardiol. , vol.50
    • Anderson, J.L.1
  • 7
    • 77953911457 scopus 로고    scopus 로고
    • Consensus and future directions on the defnition of high on-treatment platelet reactivity to adenosine diphosphate
    • Bonello, L. et al. consensus and future directions on the defnition of high on-treatment platelet reactivity to adenosine diphosphate. J. Am. Coll. Cardiol. 56, 919-933 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.56 , pp. 919-933
    • Bonello, L.1
  • 8
    • 33750479499 scopus 로고    scopus 로고
    • Impact of the degree of peri-interventional platelet inhibition after loading with clopidogrel on early clinical outcome of elective coronary stent placement
    • Hochholzer, W. et al. Impact of the degree of peri-interventional platelet inhibition after loading with clopidogrel on early clinical outcome of elective coronary stent placement. J. Am. Coll. Cardiol. 48, 1742-1750 (2006).
    • (2006) J. Am. Coll. Cardiol. , vol.48 , pp. 1742-1750
    • Hochholzer, W.1
  • 9
    • 43049179414 scopus 로고    scopus 로고
    • Cytochrome P450 2c19 681GA polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents
    • Trenk, D. et al. cytochrome P450 2c19 681GA polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents. J. Am. Coll. Cardiol. 51, 1925-1934 (2008).
    • (2008) J. Am. Coll. Cardiol. , vol.51 , pp. 1925-1934
    • Trenk, D.1
  • 10
    • 60949083948 scopus 로고    scopus 로고
    • Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis
    • Sibbing, D. et al. Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis. J. Am. Coll. Cardiol. 53, 849-856 (2009).
    • (2009) J. Am. Coll. Cardiol. , vol.53 , pp. 849-856
    • Sibbing, D.1
  • 11
    • 76349098199 scopus 로고    scopus 로고
    • Cytochrome 2c19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement
    • Sibbing, D. et al. cytochrome 2c19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement. Circulation 121, 512-518 (2010).
    • (2010) Circulation , vol.121 , pp. 512-518
    • Sibbing, D.1
  • 12
    • 77952591958 scopus 로고    scopus 로고
    • Impact of cytochrome P450 2c19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placement
    • Hochholzer, W. et al. Impact of cytochrome P450 2c19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placement. J. Am. Coll. Cardiol. 55, 2427-2434 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.55 , pp. 2427-2434
    • Hochholzer, W.1
  • 13
    • 0033678468 scopus 로고    scopus 로고
    • Identifcation and biological activity of the active metabolite of clopidogrel
    • Savi, P. et al. Identifcation and biological activity of the active metabolite of clopidogrel. Thromb. Haemost. 84, 891-896 (2000).
    • (2000) Thromb. Haemost. , vol.84 , pp. 891-896
    • Savi, P.1
  • 14
    • 0035967496 scopus 로고    scopus 로고
    • Point-of-care measured platelet inhibition correlates with a reduced risk of an adverse cardiac event after percutaneous coronary intervention: Results of the GOLD (AU-Assessing Ultegra) multicenter study
    • Steinhubl, S.R. et al. Point-of-care measured platelet inhibition correlates with a reduced risk of an adverse cardiac event after percutaneous coronary intervention: results of the GOLD (AU-Assessing Ultegra) multicenter study. Circulation 103, 2572-2578 (2001).
    • (2001) Circulation , vol.103 , pp. 2572-2578
    • Steinhubl, S.R.1
  • 15
    • 0038649988 scopus 로고    scopus 로고
    • Clopidogrel for coronary stenting: Response variability, drug resistance, and the efect of pretreatment platelet reactivity
    • Gurbel, P.A., Bliden, K.P., Hiatt, B.L. & O'connor, C.M. clopidogrel for coronary stenting: response variability, drug resistance, and the efect of pretreatment platelet reactivity. Circulation 107, 2908-2913 (2003).
    • (2003) Circulation , vol.107 , pp. 2908-2913
    • Gurbel, P.A.1    Bliden, K.P.2    Hiatt, B.L.3    O'Connor, C.M.4
  • 16
    • 77249113768 scopus 로고    scopus 로고
    • Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation
    • Breet, N.J. et al. comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation. JAMA 303, 754-762 (2010).
    • (2010) JAMA , vol.303 , pp. 754-762
    • Breet, N.J.1
  • 17
    • 77956353401 scopus 로고    scopus 로고
    • Prognostic signifcance of high on-clopidogrel platelet reactivity after percutaneous coronary intervention: Systematic review and meta-analysis
    • Aradi, D. et al. Prognostic signifcance of high on-clopidogrel platelet reactivity after percutaneous coronary intervention: systematic review and meta-analysis. Am. Heart J. 160, 543-551 (2010).
    • (2010) Am. Heart J. , vol.160 , pp. 543-551
    • Aradi, D.1
  • 18
    • 80052167250 scopus 로고    scopus 로고
    • Impact of platelet reactivity on clinical outcomes after percutaneous coronary intervention. A collaborative meta-analysis of individual participant data
    • Brar, S.S. et al. Impact of platelet reactivity on clinical outcomes after percutaneous coronary intervention. A collaborative meta-analysis of individual participant data. J. Am. Coll. Cardiol. 58, 1945-1954 (2011).
    • (2011) J. Am. Coll. Cardiol. , vol.58 , pp. 1945-1954
    • Brar, S.S.1
  • 19
    • 33747874088 scopus 로고    scopus 로고
    • A randomized comparison of high clopidogrel loading doses in patients with non-St-segment elevation acute coronary syndromes: The ALBION (Assessment of the Best Loading Dose of clopidogrel to Blunt Platelet Activation, Infammation and Ongoing Necrosis) trial
    • Montalescot, G. et al. A randomized comparison of high clopidogrel loading doses in patients with non-St-segment elevation acute coronary syndromes: the ALBION (Assessment of the Best Loading Dose of clopidogrel to Blunt Platelet Activation, Infammation and Ongoing Necrosis) trial. J. Am. Coll. Cardiol. 48, 931-938 (2006).
    • (2006) J. Am. Coll. Cardiol. , vol.48 , pp. 931-938
    • Montalescot, G.1
  • 20
    • 27744516843 scopus 로고    scopus 로고
    • Absorption, metabolization, and antiplatelet efects of 300-, 600-, and 900-mg loading doses of clopidogrel: Results of the ISAR-cHOIcE (Intracoronary Stenting and Antithrombotic Regimen: Choose between 3 High Oral Doses for Immediate clopidogrel Efect) trial
    • von Beckerath, N., Taubert, D., Pogatsa-Murray, G., Schömig, E., Kastrati, A. & Schömig, A. Absorption, metabolization, and antiplatelet efects of 300-, 600-, and 900-mg loading doses of clopidogrel: results of the ISAR-cHOIcE (Intracoronary Stenting and Antithrombotic Regimen: choose Between 3 High Oral Doses for Immediate clopidogrel Efect) trial. Circulation 112, 2946-2950 (2005).
    • (2005) Circulation , vol.112 , pp. 2946-2950
    • Von Beckerath, N.1    Taubert, D.2    Pogatsa-Murray, G.3    Schömig, E.4    Kastrati, A.5    Schömig, A.6
  • 21
    • 19644372173 scopus 로고    scopus 로고
    • Time dependence of platelet inhibition after a 600-mg loading dose of clopidogrel in a large, unselected cohort of candidates for percutaneous coronary intervention
    • Hochholzer, W. et al. time dependence of platelet inhibition after a 600-mg loading dose of clopidogrel in a large, unselected cohort of candidates for percutaneous coronary intervention. Circulation 111, 2560-2564 (2005).
    • (2005) Circulation , vol.111 , pp. 2560-2564
    • Hochholzer, W.1
  • 22
    • 41249093357 scopus 로고    scopus 로고
    • Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: A multicenter randomized prospective study
    • Bonello, L. et al. Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: a multicenter randomized prospective study. J. Am. Coll. Cardiol. 51, 1404-1411 (2008).
    • (2008) J. Am. Coll. Cardiol. , vol.51 , pp. 1404-1411
    • Bonello, L.1
  • 23
    • 33847130538 scopus 로고    scopus 로고
    • Randomized comparison of a high clopidogrel maintenance dose in patients with diabetes mellitus and coronary artery disease: Results of the Optimizing Antiplatelet therapy in Diabetes Mellitus (OPtIMUS) study
    • Angiolillo, D.J. et al. Randomized comparison of a high clopidogrel maintenance dose in patients with diabetes mellitus and coronary artery disease: results of the Optimizing Antiplatelet therapy in Diabetes Mellitus (OPtIMUS) study. Circulation 115, 708-716 (2007).
    • (2007) Circulation , vol.115 , pp. 708-716
    • Angiolillo, D.J.1
  • 24
    • 59049103979 scopus 로고    scopus 로고
    • Antiplatelet response to the 150-mg maintenance dose of clopidogrel in patients with insufcient platelet inhibition after clopidogrel loading for elective coronary stent placement
    • Trenk, D. et al. Antiplatelet response to the 150-mg maintenance dose of clopidogrel in patients with insufcient platelet inhibition after clopidogrel loading for elective coronary stent placement. EuroIntervention 4, 214-221 (2008).
    • (2008) EuroIntervention , vol.4 , pp. 214-221
    • Trenk, D.1
  • 25
    • 34248397644 scopus 로고    scopus 로고
    • A double-blind, randomized study on platelet aggregation in patients treated with a daily dose of 150 or 75 mg of clopidogrel for 30 days
    • von Beckerath, N. et al. A double-blind, randomized study on platelet aggregation in patients treated with a daily dose of 150 or 75 mg of clopidogrel for 30 days. Eur. Heart J. 28, 1814-1819 (2007).
    • (2007) Eur. Heart J. , vol.28 , pp. 1814-1819
    • Von Beckerath, N.1
  • 26
    • 37349111065 scopus 로고    scopus 로고
    • Prasugrel compared with high loading-and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: The Prasugrel in comparison to clopidogrel for Inhibition of Platelet Activation and Aggregation-thrombolysis in Myocardial Infarction 44 trial
    • Wiviott, S.D. et al. Prasugrel compared with high loading-and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: the Prasugrel in comparison to clopidogrel for Inhibition of Platelet Activation and Aggregation-thrombolysis in Myocardial Infarction 44 trial. Circulation 116, 2923-2932 (2007).
    • (2007) Circulation , vol.116 , pp. 2923-2932
    • Wiviott, S.D.1
  • 27
    • 38949144302 scopus 로고    scopus 로고
    • Switching directly to prasugrel from clopidogrel results in greater inhibition of platelet aggregation in aspirin-treated subjects
    • Payne, C.D., et al. Switching directly to prasugrel from clopidogrel results in greater inhibition of platelet aggregation in aspirin-treated subjects. Platelets 19, 275-281 (2008).
    • (2008) Platelets , vol.19 , pp. 275-281
    • Payne, C.D.1
  • 28
    • 77956681628 scopus 로고    scopus 로고
    • Increased platelet inhibition after switching from maintenance clopidogrel to prasugrel in patients with acute coronary syndromes: Results of the SWAP (SWitching Anti Platelet) study
    • Angiolillo, D.J. et al. Increased platelet inhibition after switching from maintenance clopidogrel to prasugrel in patients with acute coronary syndromes: results of the SWAP (SWitching Anti Platelet) study. J. Am. Coll. Cardiol. 56, 1017-1023 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.56 , pp. 1017-1023
    • Angiolillo, D.J.1
  • 29
    • 77950508416 scopus 로고    scopus 로고
    • Response to ticagrelor in clopidogrel nonresponders and responders and efect of switching therapies: The RESPOND study
    • Gurbel, P.A. et al. Response to ticagrelor in clopidogrel nonresponders and responders and efect of switching therapies: the RESPOND study. Circulation 121, 1188-1199 (2010).
    • (2010) Circulation , vol.121 , pp. 1188-1199
    • Gurbel, P.A.1
  • 30
    • 62549101321 scopus 로고    scopus 로고
    • Randomized comparison of adjunctive cilostazol versus high maintenance dose clopidogrel in patients with high post-treatment platelet reactivity: Results of the AccEL-RESIStANcE (Adjunctive cilostazol Versus High Maintenance Dose clopidogrel in Patients with clopidogrel Resistance) randomized study
    • Jeong, Y.H. et al. Randomized comparison of adjunctive cilostazol versus high maintenance dose clopidogrel in patients with high post-treatment platelet reactivity: results of the AccEL-RESIStANcE (Adjunctive cilostazol Versus High Maintenance Dose clopidogrel in Patients With clopidogrel Resistance) randomized study. J. Am. Coll. Cardiol. 53, 1101-1109 (2009).
    • (2009) J. Am. Coll. Cardiol. , vol.53 , pp. 1101-1109
    • Jeong, Y.H.1
  • 31
    • 57549099501 scopus 로고    scopus 로고
    • Glycoprotein IIb/IIIa inhibitors improve outcome after coronary stenting in clopidogrel nonresponders: A prospective, randomized study
    • Cuisset, t. et al. Glycoprotein IIb/IIIa inhibitors improve outcome after coronary stenting in clopidogrel nonresponders: a prospective, randomized study. JACC. Cardiovasc. Interv. 1, 649-653 (2008).
    • (2008) JACC. Cardiovasc. Interv. , vol.1 , pp. 649-653
    • Cuisset, T.1
  • 32
    • 36148983750 scopus 로고    scopus 로고
    • Prasugrel versus clopidogrel in patients with acute coronary syndromes
    • Wiviott, S.D. et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N. Engl. J. Med. 357, 2001-2015 (2007).
    • (2007) N. Engl. J. Med. , vol.357 , pp. 2001-2015
    • Wiviott, S.D.1
  • 33
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    • Wallentin, L. et al. ticagrelor versus clopidogrel in patients with acute coronary syndromes. N. Engl. J. Med. 361, 1045-1057 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1045-1057
    • Wallentin, L.1
  • 34
    • 77956290748 scopus 로고    scopus 로고
    • Dose comparisons of clopidogrel and aspirin in acute coronary syndromes
    • Mehta, S.R. et al. Dose comparisons of clopidogrel and aspirin in acute coronary syndromes. N. Engl. J. Med. 363, 930-942 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 930-942
    • Mehta, S.R.1
  • 35
    • 80053080512 scopus 로고    scopus 로고
    • High residual platelet reactivity after clopidogrel loading and long-term cardiovascular events among patients with acute coronary syndromes undergoing PcI
    • Parodi, G. et al. High residual platelet reactivity after clopidogrel loading and long-term cardiovascular events among patients with acute coronary syndromes undergoing PcI. JAMA 306, 1215-1223 (2011).
    • (2011) JAMA , vol.306 , pp. 1215-1223
    • Parodi, G.1
  • 36
    • 79952598836 scopus 로고    scopus 로고
    • Standard-vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: The GRAVItAS randomized trial
    • Price, M.J. et al. Standard-vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVItAS randomized trial. JAMA 305, 1097-1105 (2011).
    • (2011) JAMA , vol.305 , pp. 1097-1105
    • Price, M.J.1
  • 37
    • 84861857758 scopus 로고    scopus 로고
    • A Randomized trial of Prasugrel Versus clopidogrel in Patients with High Platelet Reactivity on clopidogrel after Elective Percutaneous coronary Intervention with Implantation of Drug-Eluting Stents: Results of the tRIGGER-PcI (testing Platelet Reactivity in Patients Undergoing Elective Stent Placement on clopidogrel to Guide Alternative therapy with Prasugrel) Study
    • Trenk, D. et al. A Randomized trial of Prasugrel Versus clopidogrel in Patients With High Platelet Reactivity on clopidogrel After Elective Percutaneous coronary Intervention With Implantation of Drug-Eluting Stents: Results of the tRIGGER-PcI (testing Platelet Reactivity In Patients Undergoing Elective Stent Placement on clopidogrel to Guide Alternative therapy With Prasugrel) Study. J. Am. Coll. Cardiol. 59, 2159-2164 (2012).
    • (2012) J. Am. Coll. Cardiol. , vol.59 , pp. 2159-2164
    • Trenk, D.1
  • 38
    • 33751080762 scopus 로고    scopus 로고
    • Impact of P-glycoprotein on clopidogrel absorption
    • Taubert, D. et al. Impact of P-glycoprotein on clopidogrel absorption. Clin. Pharmacol. Ther. 80, 486-501 (2006).
    • (2006) Clin. Pharmacol. Ther. , vol.80 , pp. 486-501
    • Taubert, D.1
  • 39
    • 58749090547 scopus 로고    scopus 로고
    • Genetic determinants of response to clopidogrel and cardiovascular events
    • Simon, t. et al. Genetic determinants of response to clopidogrel and cardiovascular events. N. Engl. J. Med. 360, 363-375 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 363-375
    • Simon, T.1
  • 40
    • 77958105401 scopus 로고    scopus 로고
    • Genetic variants in ABcB1 and cYP2c19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the tRItON-tIMI 38 trial: A pharmacogenetic analysis
    • Mega, J.L. et al. Genetic variants in ABcB1 and cYP2c19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the tRItON-tIMI 38 trial: a pharmacogenetic analysis. Lancet 376, 1312-1319 (2010).
    • (2010) Lancet , vol.376 , pp. 1312-1319
    • Mega, J.L.1
  • 41
    • 77952632635 scopus 로고    scopus 로고
    • Polymorphism of MDR-1 and the organic anion-transporting polypeptide (OAtP) 1B1 have no impact on antiplatelet efect of a 600-mg loading dose of clopidogrel in patients undergoing PcI
    • Abstract P4781
    • Trenk, D., Hochholzer, W., Fromm, M.F., Kleyer, A., Pahl, A., Neumann, F.-J. Polymorphism of MDR-1 and the organic anion-transporting polypeptide (OAtP) 1B1 have no impact on antiplatelet efect of a 600-mg loading dose of clopidogrel in patients undergoing PcI. Eur Heart J 29 (suppl.), 832 Abstract P4781 (2008).
    • (2008) Eur Heart J , vol.29 , Issue.SUPPL. , pp. 832
    • Trenk, D.1    Hochholzer, W.2    Fromm, M.F.3    Kleyer, A.4    Pahl, A.5    Neumann, F.-J.6
  • 42
    • 69249219296 scopus 로고    scopus 로고
    • Association of cytochrome P450 2c19 genotype with the antiplatelet efect and clinical efcacy of clopidogrel therapy
    • Shuldiner, A.R. et al. Association of cytochrome P450 2c19 genotype with the antiplatelet efect and clinical efcacy of clopidogrel therapy. JAMA 302, 849-857 (2009).
    • (2009) JAMA , vol.302 , pp. 849-857
    • Shuldiner, A.R.1
  • 43
    • 77958100874 scopus 로고    scopus 로고
    • Efect of cYP2c19 and ABcB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: A genetic substudy of the PLAtO trial
    • Wallentin, L. et al. Efect of cYP2c19 and ABcB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLAtO trial. Lancet 376, 1320-1328 (2010).
    • (2010) Lancet , vol.376 , pp. 1320-1328
    • Wallentin, L.1
  • 44
    • 84861329078 scopus 로고    scopus 로고
    • ABcB1 c3435t polymorphism and risk of adverse clinical events in clopidogrel treated patients: A meta-analysis
    • Luo, M., Li, J., Xu, X., Sun, X. & Sheng, W. ABcB1 c3435t polymorphism and risk of adverse clinical events in clopidogrel treated patients: a meta-analysis. Thromb. Res. 129, 754-759 (2012).
    • (2012) Thromb. Res. , vol.129 , pp. 754-759
    • Luo, M.1    Li, J.2    Xu, X.3    Sun, X.4    Sheng, W.5
  • 45
    • 0038508970 scopus 로고    scopus 로고
    • The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin
    • clarke, t.A. & Waskell, L.A. the metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin. Drug Metab. Dispos. 31, 53-59 (2003).
    • (2003) Drug Metab. Dispos. , vol.31 , pp. 53-59
    • Clarke, T.A.1    Waskell, L.A.2
  • 46
    • 34247181997 scopus 로고    scopus 로고
    • In vitro metabolism of antiplatelet agent clopidogrel: Cytochrome P450 isoforms responsible for two oxidation steps involved in the active metabolite formation
    • Kurihara, A., Hagihara, K., Kazui, M., Ozeki, t., Farid, N.A. & Ikeda, t. In vitro metabolism of antiplatelet agent clopidogrel: cytochrome P450 isoforms responsible for two oxidation steps involved in the active metabolite formation. Drug Metab Rev. 37, 99 (2005).
    • (2005) Drug Metab Rev. , vol.37 , pp. 99
    • Kurihara, A.1    Hagihara, K.2    Kazui, M.3    Ozeki, T.4    Farid, N.A.5    Ikeda, T.6
  • 47
    • 33749339075 scopus 로고    scopus 로고
    • Cytochrome P450 2c19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
    • Hulot, J.S. et al. cytochrome P450 2c19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects. Blood 108, 2244-2247 (2006).
    • (2006) Blood , vol.108 , pp. 2244-2247
    • Hulot, J.S.1
  • 48
    • 79960613122 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation consortium guidelines for cytochrome P450-2c19 (cYP2c19) genotype and clopidogrel therapy
    • Scott, S.A. et al. clinical Pharmacogenetics Implementation consortium guidelines for cytochrome P450-2c19 (cYP2c19) genotype and clopidogrel therapy. Clin. Pharmacol. Ther. 90, 328-332 (2011).
    • (2011) Clin. Pharmacol. Ther. , vol.90 , pp. 328-332
    • Scott, S.A.1
  • 49
    • 38449103046 scopus 로고    scopus 로고
    • Cytochrome P450 2c19 loss-of-function polymorphism, but not cYP3A4 IVS10 + 12G/A and P2Y12 t744c polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients
    • Giusti, B. et al. cytochrome P450 2c19 loss-of-function polymorphism, but not cYP3A4 IVS10 + 12G/A and P2Y12 t744c polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients. Pharmacogenet. Genomics 17, 1057-1064 (2007).
    • (2007) Pharmacogenet. Genomics , vol.17 , pp. 1057-1064
    • Giusti, B.1
  • 50
    • 55449137355 scopus 로고    scopus 로고
    • CYP2c19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation
    • Geisler, t. et al. cYP2c19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation. Pharmacogenomics 9, 1251-1259 (2008).
    • (2008) Pharmacogenomics , vol.9 , pp. 1251-1259
    • Geisler, T.1
  • 51
    • 58249135635 scopus 로고    scopus 로고
    • Cytochrome P450 2c19 polymorphism in young patients treated with clopidogrel after myocardial infarction: A cohort study
    • Collet, J.P. et al. cytochrome P450 2c19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study. Lancet 373, 309-317 (2009).
    • (2009) Lancet , vol.373 , pp. 309-317
    • Collet, J.P.1
  • 52
    • 58749094444 scopus 로고    scopus 로고
    • Cytochrome p-450 polymorphisms and response to clopidogrel
    • Mega, J.L. et al. cytochrome p-450 polymorphisms and response to clopidogrel. N. Engl. J. Med. 360, 354-362 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 354-362
    • Mega, J.L.1
  • 53
    • 78049326068 scopus 로고    scopus 로고
    • Reduced-function cYP2c19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PcI: A meta-analysis
    • Mega, J.L. et al. Reduced-function cYP2c19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PcI: a meta-analysis. JAMA 304, 1821-1830 (2010).
    • (2010) JAMA , vol.304 , pp. 1821-1830
    • Mega, J.L.1
  • 54
    • 84872211818 scopus 로고    scopus 로고
    • US Food and Drug Administration. FDA Drug Safety Communication: Reduced Efectiveness Of Plavix (clopidogrel) In Patients Who Are Poor Metabolizers Of The Drug Accessed 3 December 2010
    • US Food and Drug Administration. FDA Drug Safety communication: reduced efectiveness of Plavix (clopidogrel) in patients who are poor metabolizers of the drug http://www.fda.gov/Drugs/DrugSafety/ PostmarketDrugSafetyInformationforPatientsandProviders/ucm203888htm. Accessed 3 December 2010.
  • 55
    • 77955416969 scopus 로고    scopus 로고
    • Isolated and interactive impact of common cYP2c19 genetic variants on the antiplatelet efect of chronic clopidogrel therapy
    • Sibbing, D. et al. Isolated and interactive impact of common cYP2c19 genetic variants on the antiplatelet efect of chronic clopidogrel therapy. J. Thromb. Haemost. 8, 1685-1693 (2010).
    • (2010) J. Thromb. Haemost. , vol.8 , pp. 1685-1693
    • Sibbing, D.1
  • 56
    • 67949120411 scopus 로고    scopus 로고
    • The cYP2c19*17 allele is associated with better platelet response to clopidogrel in patients admitted for non-St acute coronary syndrome
    • Frére, C., Cuisset, t., Gaborit, B., Alessi, M.c. & Hulot, J.S. the cYP2c19*17 allele is associated with better platelet response to clopidogrel in patients admitted for non-St acute coronary syndrome. J. Thromb. Haemost. 7, 1409-1411 (2009).
    • (2009) J. Thromb. Haemost. , vol.7 , pp. 1409-1411
    • Frére, C.1    Cuisset, T.2    Gaborit, B.3    Alessi, M.C.4    Hulot, J.S.5
  • 57
    • 79951785678 scopus 로고    scopus 로고
    • First analysis of the relation between cYP2c19 genotype and pharmacodynamics in patients treated with ticagrelor versus clopidogrel: The ONSEt/OFFSEt and RESPOND genotype studies
    • Tantry, U.S. et al. First analysis of the relation between cYP2c19 genotype and pharmacodynamics in patients treated with ticagrelor versus clopidogrel: the ONSEt/OFFSEt and RESPOND genotype studies. Circ. Cardiovasc. Genet. 3, 556-566 (2010).
    • (2010) Circ. Cardiovasc. Genet. , vol.3 , pp. 556-566
    • Tantry, U.S.1
  • 58
    • 0027412483 scopus 로고
    • Identifcation of a distinct human high-density lipoprotein subspecies defned by a lipoprotein-associated protein, K-45. Identity of K-45 with paraoxonase
    • Blatter, M.C., James, R.W., Messmer, S., Barja, F. & Pometta, D. Identifcation of a distinct human high-density lipoprotein subspecies defned by a lipoprotein-associated protein, K-45. Identity of K-45 with paraoxonase. Eur. J. Biochem. 211, 871-879 (1993).
    • (1993) Eur. J. Biochem. , vol.211 , pp. 871-879
    • Blatter, M.C.1    James, R.W.2    Messmer, S.3    Barja, F.4    Pometta, D.5
  • 59
    • 78651239845 scopus 로고    scopus 로고
    • Paraoxonase-1 is a major determinant of clopidogrel efcacy
    • Bouman, H.J. et al. Paraoxonase-1 is a major determinant of clopidogrel efcacy. Nat. Med. 17, 110-116 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 110-116
    • Bouman, H.J.1
  • 60
    • 80051584505 scopus 로고    scopus 로고
    • Relationship between paraoxonase-1 activity, its Q192R genetic variant and clopidogrel responsiveness in the ADRIE study
    • Fontana, P. et al. Relationship between paraoxonase-1 activity, its Q192R genetic variant and clopidogrel responsiveness in the ADRIE study. J. Thromb. Haemost. 9, 1664-1666 (2011).
    • (2011) J. Thromb. Haemost. , vol.9 , pp. 1664-1666
    • Fontana, P.1
  • 61
    • 80052969477 scopus 로고    scopus 로고
    • Paraoxonase 1 (PON1) gene variants are not associated with clopidogrel response
    • Lewis, J.P. et al. Paraoxonase 1 (PON1) gene variants are not associated with clopidogrel response. Clin. Pharmacol. Ther. 90, 568-574 (2011).
    • (2011) Clin. Pharmacol. Ther. , vol.90 , pp. 568-574
    • Lewis, J.P.1
  • 62
    • 80052953534 scopus 로고    scopus 로고
    • Impact of genetic variants on post-clopidogrel platelet reactivity in patients after elective percutaneous coronary intervention
    • Rideg O., et al. Impact of genetic variants on post-clopidogrel platelet reactivity in patients after elective percutaneous coronary intervention. Pharmacogenomics 12, 1269-1280 (2011).
    • (2011) Pharmacogenomics , vol.12 , pp. 1269-1280
    • Rideg, O.1
  • 63
    • 79960012663 scopus 로고    scopus 로고
    • No association of paraoxonase-1 Q192R genotypes with platelet response to clopidogrel and risk of stent thrombosis after coronary stenting
    • Sibbing, D. et al. No association of paraoxonase-1 Q192R genotypes with platelet response to clopidogrel and risk of stent thrombosis after coronary stenting. Eur. Heart J. 32, 1605-1613 (2011).
    • (2011) Eur. Heart J. , vol.32 , pp. 1605-1613
    • Sibbing, D.1
  • 64
    • 80052964323 scopus 로고    scopus 로고
    • Efect of paraoxonase-1 polymorphism on clinical outcomes in patients treated with clopidogrel after an acute myocardial infarction
    • Simon, t. et al. Efect of paraoxonase-1 polymorphism on clinical outcomes in patients treated with clopidogrel after an acute myocardial infarction. Clin. Pharmacol. Ther. 90, 561-567 (2011).
    • (2011) Clin. Pharmacol. Ther. , vol.90 , pp. 561-567
    • Simon, T.1
  • 65
    • 80052790906 scopus 로고    scopus 로고
    • Paraoxonase-1 Q192R polymorphism and antiplatelet efects of clopidogrel in patients undergoing elective coronary stent placement
    • Trenk, D. et al. Paraoxonase-1 Q192R polymorphism and antiplatelet efects of clopidogrel in patients undergoing elective coronary stent placement. Circ. Cardiovasc. Genet. 4, 429-436 (2011).
    • (2011) Circ. Cardiovasc. Genet. , vol.4 , pp. 429-436
    • Trenk, D.1
  • 66
    • 80052497112 scopus 로고    scopus 로고
    • Paraoxonase-1 and clopidogrel efcacy
    • author reply 1042
    • Dansette, P.M., Rosi, J., Bertho, G. & Mansuy, D. Paraoxonase-1 and clopidogrel efcacy. Nat. Med. 17, 1040-1; author reply 1042 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 1040-1041
    • Dansette, P.M.1    Rosi, J.2    Bertho, G.3    Mansuy, D.4
  • 67
    • 84860538806 scopus 로고    scopus 로고
    • Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): A prospective, randomised, proof-of-concept trial
    • Roberts, J.D. et al. Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): a prospective, randomised, proof-of-concept trial. Lancet 379, 1705-1711 (2012).
    • (2012) Lancet , vol.379 , pp. 1705-1711
    • Roberts, J.D.1
  • 68
    • 57549092687 scopus 로고    scopus 로고
    • The pharmacogenetics and pharmacodynamics of clopidogrel response: An analysis from the PRINc (Plavix Response in coronary Intervention) trial
    • Gladding, P. et al. the pharmacogenetics and pharmacodynamics of clopidogrel response: an analysis from the PRINc (Plavix Response in coronary Intervention) trial. JACC. Cardiovasc. Interv. 1, 620-627 (2008).
    • (2008) JACC. Cardiovasc. Interv. , vol.1 , pp. 620-627
    • Gladding, P.1
  • 69
    • 77958573028 scopus 로고    scopus 로고
    • Clopidogrel loading dose adjustment according to platelet reactivity monitoring in patients carrying the 2c19*2 loss of function polymorphism
    • Bonello, L. et al. clopidogrel loading dose adjustment according to platelet reactivity monitoring in patients carrying the 2c19*2 loss of function polymorphism. J. Am. Coll. Cardiol. 56, 1630-1636 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.56 , pp. 1630-1636
    • Bonello, L.1
  • 70
    • 79955116606 scopus 로고    scopus 로고
    • High doses of clopidogrel to overcome genetic resistance: The randomized crossover cLOVIS-2 (clopidogrel and Response Variability Investigation Study 2)
    • Collet, J.P. et al. High doses of clopidogrel to overcome genetic resistance: the randomized crossover cLOVIS-2 (clopidogrel and Response Variability Investigation Study 2). JACC. Cardiovasc. Interv. 4, 392-402 (2011).
    • (2011) JACC. Cardiovasc. Interv. , vol.4 , pp. 392-402
    • Collet, J.P.1
  • 71
    • 81855211733 scopus 로고    scopus 로고
    • Dosing clopidogrel based on cYP2c19 genotype and the efect on platelet reactivity in patients with stable cardiovascular disease
    • Mega, J.L. et al. Dosing clopidogrel based on cYP2c19 genotype and the efect on platelet reactivity in patients with stable cardiovascular disease. JAMA 306, 2221-2228 (2011).
    • (2011) JAMA , vol.306 , pp. 2221-2228
    • Mega, J.L.1
  • 73
    • 78149487926 scopus 로고    scopus 로고
    • Clopidogrel with or without omeprazole in coronary artery disease
    • Bhatt, D.L. et al. clopidogrel with or without omeprazole in coronary artery disease. N. Engl. J. Med. 363, 1909-1917 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1909-1917
    • Bhatt, D.L.1
  • 74
    • 33645105318 scopus 로고    scopus 로고
    • Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450
    • Rehmel, J.L. et al. Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450. Drug Metab. Dispos. 34, 600-607 (2006).
    • (2006) Drug Metab. Dispos. , vol.34 , pp. 600-607
    • Rehmel, J.L.1
  • 75
    • 36348943475 scopus 로고    scopus 로고
    • Common polymorphisms of cYP2c19 and cYP2c9 afect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel
    • Brandt, J.t. et al. common polymorphisms of cYP2c19 and cYP2c9 afect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel. J. Thromb. Haemost. 5, 2429-2436 (2007).
    • (2007) J. Thromb. Haemost. , vol.5 , pp. 2429-2436
    • Brandt, J.T.1
  • 76
    • 66349133650 scopus 로고    scopus 로고
    • Cytochrome P450 genetic polymorphisms and the response to prasugrel: Relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes
    • Mega, J.L. et al. cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes. Circulation 119, 2553-2560 (2009).
    • (2009) Circulation , vol.119 , pp. 2553-2560
    • Mega, J.L.1
  • 77
    • 37549006004 scopus 로고    scopus 로고
    • The residual platelet aggregation after deployment of intracoronary stent (PREDIct) score
    • Geisler, t. et al. the Residual Platelet Aggregation after Deployment of Intracoronary Stent (PREDIct) score. J. Thromb. Haemost. 6, 54-61 (2008).
    • (2008) J. Thromb. Haemost. , vol.6 , pp. 54-61
    • Geisler, T.1


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