Application of a multi-route physiologically based pharmacokinetic model for manganese to evaluate dose-dependent neurological effects in monkeys

Toxicological Sciences

Volumn 129, Issue 2, 2012, Pages 432-446

  Schroeter, Jeffry D ^a   Dorman, David C ^b   Yoon, Miyoung ^a   Nong, Andy ^a   Taylor, Michael D ^c   Andersen, Melvin E ^a   Clewell, Harvey J ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c AFTON CHEMICAL CORPORATION   (United States)

Author keywords

Dose response; Manganese; Neurotoxicity; Physiologically based pharmacokinetic modeling

Indexed keywords

MANGANESE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; EXPOSURE; MODEL; NEUROTOXICITY; NONHUMAN; PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL; RHESUS MONKEY;

ANIMALS; CEBUS; DOSE-RESPONSE RELATIONSHIP, DRUG; MANGANESE; MODELS, BIOLOGICAL; RISK ASSESSMENT;

ANIMALIA; PRIMATES;

EID: 84866617741     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs212     Document Type: Article

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