-
1
-
-
0037264633
-
Targeting RAS signalling pathways in cancer therapy
-
Downward J. Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 2003;3:11-22.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
2
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 2010;363:809-19.
-
(2010)
N Engl J Med
, vol.363
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
Kim, K.B.3
Ribas, A.4
McArthur, G.A.5
Sosman, J.A.6
-
3
-
-
77949464718
-
From basic research to clinical development of MEK1/2 inhibitors for cancer therapy
-
Fremin C, Meloche S. From basic research to clinical development of MEK1/2 inhibitors for cancer therapy. J Hematol Oncol 2010;3:8.
-
(2010)
J Hematol Oncol
, vol.3
, pp. 8
-
-
Fremin, C.1
Meloche, S.2
-
5
-
-
79955980366
-
c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma
-
Blasco RB, Francoz S, Santamaria D, Canamero M, Dubus P, Charron J, et al. c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma. Cancer Cell 2011;19:652-63.
-
(2011)
Cancer Cell
, vol.19
, pp. 652-663
-
-
Blasco, R.B.1
Francoz, S.2
Santamaria, D.3
Canamero, M.4
Dubus, P.5
Charron, J.6
-
6
-
-
33750284658
-
In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling
-
Dumaz N, Hayward R, Martin J, Ogilvie L, Hedley D, Curtin JA, et al. In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling. Cancer Res 2006;66:9483-91.
-
(2006)
Cancer Res
, vol.66
, pp. 9483-9491
-
-
Dumaz, N.1
Hayward, R.2
Martin, J.3
Ogilvie, L.4
Hedley, D.5
Curtin, J.A.6
-
7
-
-
67651176150
-
Raf-1 addiction in Ras-induced skin carcinogenesis
-
Ehrenreiter K, Kern F, Velamoor V, Meissl K, Galabova-Kovacs G, Sibilia M, et al. Raf-1 addiction in Ras-induced skin carcinogenesis. Cancer Cell 2009;16:149-60.
-
(2009)
Cancer Cell
, vol.16
, pp. 149-160
-
-
Ehrenreiter, K.1
Kern, F.2
Velamoor, V.3
Meissl, K.4
Galabova-Kovacs, G.5
Sibilia, M.6
-
8
-
-
74849109743
-
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
-
Heidorn SJ, Milagre C, Whittaker S, Nourry A, Niculescu-Duvas I, Dhomen N, et al. Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell 2010;140:209-21.
-
(2010)
Cell
, vol.140
, pp. 209-221
-
-
Heidorn, S.J.1
Milagre, C.2
Whittaker, S.3
Nourry, A.4
Niculescu-Duvas, I.5
Dhomen, N.6
-
9
-
-
77949685981
-
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
-
Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 2010;464:431-5.
-
(2010)
Nature
, vol.464
, pp. 431-435
-
-
Hatzivassiliou, G.1
Song, K.2
Yen, I.3
Brandhuber, B.J.4
Anderson, D.J.5
Alvarado, R.6
-
10
-
-
77949732073
-
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wildtype BRAF
-
Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wildtype BRAF. Nature 2010;464:427-30.
-
(2010)
Nature
, vol.464
, pp. 427-430
-
-
Poulikakos, P.I.1
Zhang, C.2
Bollag, G.3
Shokat, K.M.4
Rosen, N.5
-
11
-
-
79955472800
-
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK
-
Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat KM, et al. A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. Nature 2011;472:366-9.
-
(2011)
Nature
, vol.472
, pp. 366-369
-
-
Brennan, D.F.1
Dar, A.C.2
Hertz, N.T.3
Chao, W.C.4
Burlingame, A.L.5
Shokat, K.M.6
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