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Volumn 1, Issue 2, 2011, Pages 98-99

New insight puts CRAF in sight as a therapeutic target

Author keywords

[No Author keywords available]

Indexed keywords

A RAF KINASE; B RAF KINASE; C RAF PROTEIN; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; RAF PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

EID: 84866616211     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-11-0118     Document Type: Article
Times cited : (10)

References (11)
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    • Downward, J.1
  • 3
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    • From basic research to clinical development of MEK1/2 inhibitors for cancer therapy
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    • Fremin, C.1    Meloche, S.2
  • 5
    • 79955980366 scopus 로고    scopus 로고
    • c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma
    • Blasco RB, Francoz S, Santamaria D, Canamero M, Dubus P, Charron J, et al. c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma. Cancer Cell 2011;19:652-63.
    • (2011) Cancer Cell , vol.19 , pp. 652-663
    • Blasco, R.B.1    Francoz, S.2    Santamaria, D.3    Canamero, M.4    Dubus, P.5    Charron, J.6
  • 6
    • 33750284658 scopus 로고    scopus 로고
    • In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling
    • Dumaz N, Hayward R, Martin J, Ogilvie L, Hedley D, Curtin JA, et al. In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling. Cancer Res 2006;66:9483-91.
    • (2006) Cancer Res , vol.66 , pp. 9483-9491
    • Dumaz, N.1    Hayward, R.2    Martin, J.3    Ogilvie, L.4    Hedley, D.5    Curtin, J.A.6
  • 8
    • 74849109743 scopus 로고    scopus 로고
    • Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
    • Heidorn SJ, Milagre C, Whittaker S, Nourry A, Niculescu-Duvas I, Dhomen N, et al. Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell 2010;140:209-21.
    • (2010) Cell , vol.140 , pp. 209-221
    • Heidorn, S.J.1    Milagre, C.2    Whittaker, S.3    Nourry, A.4    Niculescu-Duvas, I.5    Dhomen, N.6
  • 10
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    • RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wildtype BRAF
    • Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wildtype BRAF. Nature 2010;464:427-30.
    • (2010) Nature , vol.464 , pp. 427-430
    • Poulikakos, P.I.1    Zhang, C.2    Bollag, G.3    Shokat, K.M.4    Rosen, N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.