메뉴 건너뛰기




Volumn 61, Issue 9, 2012, Pages 1441-1450

DiVerential eVects of low-dose decitabine on immune eVector and suppressor responses in melanoma-bearing mice

Author keywords

Hypomethylation; Immunotherapy; Myeloid suppressor cells; Regulatory T cells

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ADENOVIRUS VECTOR; CYTOKINE; INTERLEUKIN 2; MELANOMA ANTIGEN; MELANOMA ANTIGEN TRP2; MELANOMA VACCINE; MELANOMA VACCINE AAV DCT; ODN 1826; TOLL LIKE RECEPTOR AGONIST; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIMETABOLITE; AZACITIDINE; CPG ODN 1826; DRUG DERIVATIVE; OLIGODEOXYRIBONUCLEOTIDE; TLR9 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 9;

EID: 84866565997     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-012-1204-x     Document Type: Article
Times cited : (36)

References (48)
  • 1
    • 0035886022 scopus 로고    scopus 로고
    • Expression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells following 5-aza-2'-deoxycytidine treatment
    • DOI 10.1002/ijc.1452
    • Serrano A, Tanzarella S, Lionello I, Mendez R, Traversari C, Ruiz-Cabello F, Garrido F (2001) Re-expression of HLA class I antigens and restoration of antigen-speciWc CTL response in melanoma cells following 5-aza-2-deoxycytidine treatment. Int J Cancer 94:243-251 (Pubitemid 32911420)
    • (2001) International Journal of Cancer , vol.94 , Issue.2 , pp. 243-251
    • Serrano, A.1    Tanzarella, S.2    Lionello, I.3    Mendez, R.4    Traversari, C.5    Ruiz-Cabello, F.6    Garrido, F.7
  • 3
    • 33745599088 scopus 로고    scopus 로고
    • Epigenetic regulation of immune escape genes in cancer
    • DOI 10.1007/s00262-006-0164-4
    • Tomasi TB, Magner WJ, Khan AN (2006) Epigenetic regulation of immune escape genes in cancer. Cancer Immunol Immunother 55:1159-1184 (Pubitemid 43992044)
    • (2006) Cancer Immunology, Immunotherapy , vol.55 , Issue.10 , pp. 1159-1184
    • Tomasi, T.B.1    Magner, W.J.2    Khan, A.N.H.3
  • 4
    • 33748046812 scopus 로고    scopus 로고
    • Phase i trial of sequential low-dose 5-aza-2-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma
    • Gollob JA, Sciambi CJ, Peterson BL, Richmond T, Thoreson M, Moran K, Dressman HK, Jelinek J, Issa JP (2006) Phase I trial of sequential low-dose 5-aza-2-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma. Clin Cancer Res 12:4619-4627
    • (2006) Clin Cancer Res , vol.12 , pp. 4619-4627
    • Gollob, J.A.1    Sciambi, C.J.2    Peterson, B.L.3    Richmond, T.4    Thoreson, M.5    Moran, K.6    Dressman, H.K.7    Jelinek, J.8    Issa, J.P.9
  • 5
    • 84866554594 scopus 로고    scopus 로고
    • http://clinicaltrials.gov/ct2/show/NCT00791271
  • 6
    • 12444252093 scopus 로고    scopus 로고
    • Interleukin 12-based immunotherapy improves the antitumor eVectiveness of a low-dose 5-Aza-2-deoxycitidine treatment in L1210 leukemia and B16F10 melanoma models in mice
    • Kozar K, Kamijski R, Switaj T, Oidak T, Machaj E, Wysocki PJ, Mackiewicz A, Lasek W, Jakóbisiak M, Goiab J (2003) Interleukin 12-based immunotherapy improves the antitumor eVectiveness of a low-dose 5-Aza-2-deoxycitidine treatment in L1210 leukemia and B16F10 melanoma models in mice. Clin Cancer Res 9:3124-3133
    • (2003) Clin Cancer Res , vol.9 , pp. 3124-3133
    • Kozar, K.1    Kamijski, R.2    Switaj, T.3    Oidak, T.4    MacHaj, E.5    Wysocki, P.J.6    MacKiewicz, A.7    Lasek, W.8    Jakóbisiak, M.9    Goiab, J.10
  • 7
    • 67649506210 scopus 로고    scopus 로고
    • Treatment with demethylating agent, 5-aza-2-deoxycytidine enhances therapeutic HPV DNA vaccine potency
    • Lu D, Hoory T, Monie A, Wu A, Wang MC, Hung CF (2009) Treatment with demethylating agent, 5-aza-2-deoxycytidine enhances therapeutic HPV DNA vaccine potency. Vaccine 27: 4363-4369
    • (2009) Vaccine , vol.27 , pp. 4363-4369
    • Lu, D.1    Hoory, T.2    Monie, A.3    Wu, A.4    Wang, M.C.5    Hung, C.F.6
  • 9
    • 0037108489 scopus 로고    scopus 로고
    • Crucial role of DNA methylation in determination of clonally distributed killer cell Ig-like receptor expression patterns in NK cells
    • Santourlidis S, Trompeter HI, Weinhold S, Eisermann B, Meyer KL, Wernet P, Uhrberg M (2002) Crucial role of DNA methylation in determination of clonally distributed killer cell Ig-like receptor expression patterns in NK cells. J Immunol 169:4253-4261 (Pubitemid 35178197)
    • (2002) Journal of Immunology , vol.169 , Issue.8 , pp. 4253-4261
    • Santourlidis, S.1    Trompeter, H.-I.2    Weinhold, S.3    Eisermann, B.4    Meyer, K.L.5    Wernet, P.6    Uhrberg, M.7
  • 10
    • 34447265236 scopus 로고    scopus 로고
    • CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: A role for DNA methylation
    • DOI 10.1084/jem.20070109
    • Kim HP, Leonard WJ (2007) CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. J Exp Med 204:1543-1551 (Pubitemid 47048022)
    • (2007) Journal of Experimental Medicine , vol.204 , Issue.7 , pp. 1543-1551
    • Kim, H.-P.1    Leonard, W.J.2
  • 12
    • 77955900102 scopus 로고    scopus 로고
    • In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacriWcing graft-versus-leukemia
    • Choi J, Ritchey J, Prior JL, Holt M, Shannon WD, Deych E, Piwnica-Worms DR, DiPersio JF (2010) In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacriWcing graft-versus-leukemia. Blood 116:129-139
    • (2010) Blood , vol.116 , pp. 129-139
    • Choi, J.1    Ritchey, J.2    Prior, J.L.3    Holt, M.4    Shannon, W.D.5    Deych, E.6    Piwnica-Worms, D.R.7    Dipersio, J.F.8
  • 13
    • 33947429267 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors suppress natural killer cell cytolytic activity
    • DOI 10.1016/j.febslet.2007.02.045, PII S001457930700213X
    • Ogbomo H, Michaelis M, Kreuter J, Doerr HW, Cinatl J Jr (2007) Histone deacetylase inhibitors suppress natural killer cell cytolytic activity. FEBS Lett 581:1317-1322 (Pubitemid 46452605)
    • (2007) FEBS Letters , vol.581 , Issue.7 , pp. 1317-1322
    • Ogbomo, H.1    Michaelis, M.2    Kreuter, J.3    Doerr, H.W.4    Cinatl Jr., J.5
  • 14
    • 58049132791 scopus 로고    scopus 로고
    • DNA methylation inhibition increases T cell KIR expression through eVects on both promoter methylation and transcription factors
    • Liu Y, Kuick R, Hanash S, Richardson B (2009) DNA methylation inhibition increases T cell KIR expression through eVects on both promoter methylation and transcription factors. Clin Immunol 130:213-224
    • (2009) Clin Immunol , vol.130 , pp. 213-224
    • Liu, Y.1    Kuick, R.2    Hanash, S.3    Richardson, B.4
  • 15
    • 3042566927 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor trichostatin A modulates CD4+ T cell responses
    • Moreira JM, Scheipers P, Sorensen P (2003) The histone deacetylase inhibitor trichostatin A modulates CD4+ T cell responses. BMC Cancer (http://www.biomedcentral.com/1471-2407/3/30)
    • (2003) BMC Cancer
    • Moreira, J.M.1    Scheipers, P.2    Sorensen, P.3
  • 17
    • 33846876336 scopus 로고    scopus 로고
    • Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function
    • DOI 10.1182/blood-2006-04-019711
    • Brogdon JL, Xu Y, Szabo SJ, An S, Buxton F, Cohen D, Huang Q (2007) Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 eVector cell function. Blood 109:1123-1130 (Pubitemid 46220659)
    • (2007) Blood , vol.109 , Issue.3 , pp. 1123-1130
    • Brogdon, J.L.1    Xu, Y.2    Szabo, S.J.3    An, S.4    Buxton, F.5    Cohen, D.6    Huang, Q.7
  • 18
    • 33750732640 scopus 로고    scopus 로고
    • Effect of trichostatin A on CD4 surface density in peripheral blood T cells
    • Kozlowska A, Jagodzinski PP (2006) EVect of trichostatin A on CD4 surface density in peripheral blood T cells. Folia Histochem Cytobiol 44:259-262 (Pubitemid 44696966)
    • (2006) Folia Histochemica et Cytobiologica , vol.44 , Issue.4 , pp. 259-262
    • Kozlowska, A.1    Jagodzinski, P.P.2
  • 19
    • 0036667345 scopus 로고    scopus 로고
    • In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production
    • Guo L, Hu-Li J, Zhu J, Watson CJ, DiWlippantonio MJ, Pannetier C, Paul WE (2002) In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production. Proc Natl Acad Sci USA 99:10623-10628
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10623-10628
    • Guo, L.1    Hu-Li, J.2    Zhu, J.3    Watson, C.J.4    Diwlippantonio, M.J.5    Pannetier, C.6    Paul, W.E.7
  • 23
    • 33745946911 scopus 로고    scopus 로고
    • Therapeutic potential of toll-like receptor 9 activation
    • DOI 10.1038/nrd2059, PII NRD2059
    • Krieg AM (2006) Therapeutic potential of Toll-like receptor 9 activation. Nat Rev Drug Discov 5:471-484 (Pubitemid 44136959)
    • (2006) Nature Reviews Drug Discovery , vol.5 , Issue.6 , pp. 471-484
    • Krieg, A.M.1
  • 24
    • 78650239955 scopus 로고    scopus 로고
    • Regulation of the activity of an adeno-associated virus vector cancer vaccine administered with synthetic Toll-like receptor agonists
    • Triozzi PL, Aldrich A, Ponnazhagan S (2010) Regulation of the activity of an adeno-associated virus vector cancer vaccine administered with synthetic Toll-like receptor agonists. Vaccine 28:7837-7843
    • (2010) Vaccine , vol.28 , pp. 7837-7843
    • Triozzi, P.L.1    Aldrich, A.2    Ponnazhagan, S.3
  • 25
    • 35948937212 scopus 로고    scopus 로고
    • A half-log increase in BCR-ABL RNA predicts a higher risk of relapse in patients with chronic myeloid leukemia with an imatinib-induced complete cytogenetic response
    • DOI 10.1158/1078-0432.CCR-07-1112
    • Press RD, Galderisi C, Yang R, Rempfer C, Willis SG, Mauro MJ, Druker BJ, Deininger MW (2007) A half-log increase in BCRABL RNA predicts a higher risk of relapse in patients with chronic myeloid leukemia with an imatinib-induced complete cytogenetic response. Clin Cancer Res 13:6136-6143 (Pubitemid 350075073)
    • (2007) Clinical Cancer Research , vol.13 , Issue.20 , pp. 6136-6143
    • Press, R.D.1    Galderisi, C.2    Yang, R.3    Rempfer, C.4    Willis, S.G.5    Mauro, M.J.6    Druker, B.J.7    Deininger, M.W.N.8
  • 27
    • 33947305783 scopus 로고    scopus 로고
    • Epigenetic events in malignant melanoma
    • DOI 10.1111/j.1600-0749.2007.00367.x
    • Rothhammer T, BosserhoV AK (2007) Epigenetic events in malignant melanoma. Pigment Cell Res 20:92-111 (Pubitemid 46439524)
    • (2007) Pigment Cell Research , vol.20 , Issue.2 , pp. 92-111
    • Rothhammer, T.1    Bosserhoff, A.-K.2
  • 28
    • 33846912817 scopus 로고    scopus 로고
    • Macrophages are essential for antitumour effects against weakly immunogenic murine tumours induced by class B CpG-oligodeoxynucleotides
    • DOI 10.1111/j.1365-2567.2006.02517.x
    • Buhtoiarov IN, Sondel PM, EickhoV JC, Rakhmilevich AL (2007) Macrophages are essential for antitumour eVects against weakly immunogenic murine tumours induced by class B CpG-oligodeoxynucleotides. Immunology 120:412-423 (Pubitemid 46232916)
    • (2007) Immunology , vol.120 , Issue.3 , pp. 412-423
    • Buhtoiarov, I.N.1    Sondel, P.M.2    Eickhoff, J.C.3    Rakhmilevich, A.L.4
  • 31
    • 77950498798 scopus 로고    scopus 로고
    • Generation of antigen-presenting cells from tumor-inWltrated CD11b myeloid cells with DNA demethylating agent 5-aza-2-deoxycytidine
    • Daurkin I, Eruslanov E, Vieweg J, Kusmartsev S (2010) Generation of antigen-presenting cells from tumor-inWltrated CD11b myeloid cells with DNA demethylating agent 5-aza-2-deoxycytidine. Cancer Immunol Immunother 59:697-706
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 697-706
    • Daurkin, I.1    Eruslanov, E.2    Vieweg, J.3    Kusmartsev, S.4
  • 32
    • 79955413027 scopus 로고    scopus 로고
    • Azacytidine impairs NK cell reactivity while decitabine augments NK cell responsiveness toward stimulation
    • Schmiedel BJ, Arélin V, Gruenebach F, Krusch M, Schmidt SM, Salih HR (2011) Azacytidine impairs NK cell reactivity while decitabine augments NK cell responsiveness toward stimulation. Int J Cancer 128:2911-2922
    • (2011) Int J Cancer , vol.128 , pp. 2911-2922
    • Schmiedel, B.J.1    Arélin, V.2    Gruenebach, F.3    Krusch, M.4    Schmidt, S.M.5    Salih, H.R.6
  • 33
    • 77954027739 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors prevent activation of tumourreactive NK cells and T cells but do not interfere with their cytolytic eVector functions
    • Schmudde M, Friebe E, Sonnemann J, Beck JF, Bröker BM (2010) Histone deacetylase inhibitors prevent activation of tumourreactive NK cells and T cells but do not interfere with their cytolytic eVector functions. Cancer Lett 295:173-181
    • (2010) Cancer Lett , vol.295 , pp. 173-181
    • Schmudde, M.1    Friebe, E.2    Sonnemann, J.3    Beck, J.F.4    Bröker, B.M.5
  • 36
    • 34547653955 scopus 로고    scopus 로고
    • Synergistic in vivo antitumor effect of the histone deacetylase inhibitor MS-275 in combination with interleukin 2 in a murine model of renal cell carcinoma
    • DOI 10.1158/1078-0432.CCR-07-0014
    • Kato Y, Yoshimura K, Shin T, Verheul H, Hammers H, Sanni TB, Salumbides BC, Van Erp K, Schulick R, Pili R (2007) Synergistic in vivo antitumor eVect of the histone deacetylase inhibitor MS-275 in combination with interleukin 2 in a murine model of renal cell carcinoma. Clin Cancer Res 13(15 Pt 1):4538-4546 (Pubitemid 47219724)
    • (2007) Clinical Cancer Research , vol.13 , Issue.15 , pp. 4538-4546
    • Kato, Y.1    Yoshimura, K.2    Shin, T.3    Verheul, H.4    Hammers, H.5    Sanni, T.B.6    Salumbides, B.C.7    Van Erp, K.8    Schulick, R.9    Pili, R.10
  • 37
    • 0035901090 scopus 로고    scopus 로고
    • InXammation and cancer: Back to Virchow?
    • Balkwill F, Mantovani A (2001) InXammation and cancer: back to Virchow? Lancet 357:539-545
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 38
    • 0034695539 scopus 로고    scopus 로고
    • Control of organ-specific demethylation by an element of the T-cell receptor-α locus control region
    • DOI 10.1074/jbc.275.3.1952
    • Santoso B, Ortiz BD, Winoto A (2000) Control of organ-speciWc demethylation by an element of the T-cell receptor-alpha locus control region. J Biol Chem 275:1952-1958 (Pubitemid 30060821)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.3 , pp. 1952-1958
    • Santoso, B.1    Ortiz, B.D.2    Winoto, A.3
  • 39
    • 0036679732 scopus 로고    scopus 로고
    • Of mice and men: Species variations of Toll-like receptor expression
    • DOI 10.1016/S1471-4906(02)02259-7, PII S1471490602022597
    • Rehli M (2002) Of mice and men: species variations of Toll-like receptor expression. Trends Immunol 23:375-378 (Pubitemid 34804626)
    • (2002) Trends in Immunology , vol.23 , Issue.8 , pp. 375-378
    • Rehli, M.1
  • 40
    • 5444262511 scopus 로고    scopus 로고
    • Toll-like receptor control of the adaptive immune responses
    • DOI 10.1038/ni1112
    • Iwasaki A, Medzhitov R (2004) Toll-like receptor control of the adaptive immune responses. Nat Immunol 10:987-995 (Pubitemid 41057715)
    • (2004) Nature Immunology , vol.5 , Issue.10 , pp. 987-995
    • Iwasaki, A.1    Medzhitov, R.2
  • 41
    • 0034650833 scopus 로고    scopus 로고
    • Autocrine production of IL-10 mediates defective IL-12 production and NF-κB activation in tumor-associated macrophages
    • Sica A, Saccani A, Bottazzi B, Polentarutti N, Vecchi A, van Damme J, Mantovani A (2000) Autocrine production of IL-10 mediates defective IL-12 production and NF-kappa B activation in tumorassociated macrophages. J Immunol 164:762-767 (Pubitemid 30043699)
    • (2000) Journal of Immunology , vol.164 , Issue.2 , pp. 762-767
    • Sica, A.1    Saccani, A.2    Bottazzi, B.3    Polentarutti, N.4    Vecchi, A.5    Van Damme, J.6    Mantovani, A.7
  • 44
    • 0028907116 scopus 로고
    • Rejection of mouse melanoma elicited by local secretion of interleukin-2: Implicating macrophages without T cells or natural killer cells in tumor rejection
    • Hara I, Nguyen H, Takechi Y, Gansbacher B, Chapman PB, Houghton AN (1995) Rejection of mouse melanoma elicited by local secretion of interleukin-2: implicating macrophages without T cells or natural killer cells in tumor rejection. Int J Cancer 61:253-260
    • (1995) Int J Cancer , vol.61 , pp. 253-260
    • Hara, I.1    Nguyen, H.2    Takechi, Y.3    Gansbacher, B.4    Chapman, P.B.5    Houghton, A.N.6
  • 45
    • 54049134747 scopus 로고    scopus 로고
    • Subsets of myeloid-derived suppressor cells in tumor-bearing mice
    • Youn JI, Nagaraj S, Collazo M, Gabrilovich DI (2008) Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J Immunol 181:5791-5802
    • (2008) J Immunol , vol.181 , pp. 5791-5802
    • Youn, J.I.1    Nagaraj, S.2    Collazo, M.3    Gabrilovich, D.I.4
  • 47
    • 24644488201 scopus 로고    scopus 로고
    • The predictive value of CD8, CD4, CD68 and human leukocyte antigen-D-related cells in the prognosis of cutaneous malignant melanoma with vertical growth phase
    • DOI 10.1002/cncr.21283
    • Piras F, Colombari R, Minerba L, Murtas D, Floris C, Maxia C, Corbu A, Perra MT, Sirigu P (2005) The predictive value of CD8, CD4, CD68, and human leukocyte antigen-D-related cells in the prognosis of cutaneous malignant melanoma with vertical growth phase. Cancer 104:1246-1254 (Pubitemid 41278960)
    • (2005) Cancer , vol.104 , Issue.6 , pp. 1246-1254
    • Piras, F.1    Colombari, R.2    Minerba, L.3    Murtas, D.4    Floris, C.5    Maxia, C.6    Corby, A.7    Perra, M.T.8    Sirigu, P.9
  • 48
    • 34447258415 scopus 로고    scopus 로고
    • Identification of a new subset of myeloid suppressor cells in peripheral blood of melanoma patients with modulation by a granulocyte-macrophage colony-stimulation factor-based antitumor vaccine
    • DOI 10.1200/JCO.2006.08.5829
    • Filipazzi P, Valenti R, Huber V, Pilla L, Canese P, Iero M, Castelli C, Mariani L, Parmiani G, Rivoltini L (2007) IdentiWcation of a new subset of myeloid suppressor cells in peripheral blood of melanoma patients with modulation by a granulocyte-macrophage colony stimulation factor-based antitumor vaccine. J Clin Oncol 25:2546-2553 (Pubitemid 47041228)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.18 , pp. 2546-2553
    • Filipazzi, P.1    Valenti, R.2    Huber, V.3    Pilla, L.4    Canese, P.5    Iero, M.6    Castelli, C.7    Mariani, L.8    Parmiani, G.9    Rivoltini, L.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.