Hyaluronan: A multifunctional, megaDalton, stealth molecule

Current Opinion in Cell Biology

Volumn 12, Issue 5, 2000, Pages 581-586

  Lee, Janet Y ^a   Spicer, Andrew P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYALURONIC ACID; HYALURONIC ACID BINDING PROTEIN;

CARBOHYDRATE SYNTHESIS; CELL ADHESION; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; DEGRADATION; DEVELOPMENT; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD44; EXTRACELLULAR MATRIX; GLUCURONOSYLTRANSFERASE; GLYCOSYLTRANSFERASES; HUMANS; HYALURONIC ACID; MEMBRANE PROTEINS; MOLECULAR WEIGHT; SIGNAL TRANSDUCTION; TRANSFERASES; XENOPUS PROTEINS;

EID: 0033812683     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(00)00135-6     Document Type: Review

References (38)

1. Hyaluronan synthases: Fascinating glycosyltransferases from vertebrates, bacterial pathogens, and algal viruses
2. In vitro synthesis of hyaluronan by a single protein derived from mouse HAS1 gene and characterization of amino acid residues essential for the activity
3. Does DG42 synthesize hyaluronan or chitin?: A controversy about oligosaccharides in vertebrate development
4. The genome sequence of Drosophila melanogaster
5. Solution structure of the link module: A hyaluronan-binding domain involved in extracellular matrix stability and cell migration
6. Mice lacking link protein develop dwarfism and craniofacial abnormalities
7. Antisense inhibition of hyaluronan synthase-2 in human articular chondrocytes inhibits proteoglycan retention and matrix assembly
8. Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme
9. Formation of hyaluronan- and versican-rich pericellular matrix is required for proliferation and migration of vascular smooth muscle cells
10. The Cspg2 gene, disrupted in the hdf mutant, is required for right cardiac chamber and endocardial cushion formation
11. Hyaluronan stimulates tumor cell migration by modulating the fibrin fiber architecture
12. Overproduction of hyaluronan by expression of the hyaluronan synthase Has2 enhances anchorage-independent growth and tumorigenicity
13. Increased synthesis of hyaluronate enhances motility of human melanoma cells
14. Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells
15. Hyaluronic acid (HA) binding to CD44 activates Rac1 and induces lamellipodia outgrowth
16. CD44 interaction with Tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration
17. Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation
18. CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes
19. Ras, protein kinase Cζ, and IκB kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-κB by hyaluronic acid fragments in T-24 carcinoma cells
20. Hyaluronan fragments activate an NF-κappa B/lκappa B alpha autoregulatory loop in murine macrophages
21. Expression of recombinant hyaluronan synthase (HAS) isoforms in CHO cells reduces cell migration and cell surface CD44
22. Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties
23. LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan
24. Identification and characterization of three cDNAs that encode putative novel hyaluronan-binding proteins, including an endothelial cell-specific hyaluronan receptor
25. Intracellular localization of hyaluronan in proliferating cells
26. Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility
27. Identification of IHABP, a 95 kDa intracellular hyaluronate binding protein
28. Cdc37 is a molecular chaperone with specific functions in signal transduction
29. A model for the cytoplasmic trafficking of signalling proteins involving the hsp90-binding immunophilins and p50cdc37
30. A novel glycosaminoglycan-binding protein is the vertebrate homologue of the cell cycle control protein, Cdc37
31. Molecular cloning of human fibroblast hyaluronic acid-binding protein confirms its identity with P-32, a protein co-purified with splicing factor SF2. Hyaluronic acid-binding protein as P-32 protein, co-purified with splicing factor SF2
32. Multifunctional activities of human fibroblast 34-kDa hyaluronic acid-binding protein
33. Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein
34. The intracellular hyaluronan receptor RHAMM/IHABP interacts with microtubules and actin filaments
35. The hyaluronan receptor RHAMM regulates extracellular-regulated kinase
36. A member of the hyaladherins
37. Rapid hyaluronan uptake is associated with enhanced motility: Implication for an intracellular mode of action
38. Angiogenic oligosaccharides of hyaluronan induce protein tyrosine kinase activity in endothelial cells and activate a cytoplasmic signal transduction pathway resulting in proliferation