Optimization of a reversed-phase-high-performance thin-layer chromatography method for the separation of isoniazid, ethambutol, rifampicin and pyrazinamide in fixed-dose combination antituberculosis tablets

Journal of Chromatography A

Volumn 1260, Issue , 2012, Pages 232-238

  Shewiyo, D H ^a,b,c   Kaale, E ^b   Risha, P G ^b   Dejaegher, B ^c   Smeyers Verbeke, J ^c   Vander Heyden, Y ^c  

^a Tanzania Food and Drugs Authority   (Tanzania)

^b MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^c VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Ethambutol; Isoniazid; Mobile phase optimization; Pyrazinamide; Reversed phase HPTLC; Rifampicin

Indexed keywords

ETHAMBUTOL; ISONIAZID; MOBILE-PHASE OPTIMIZATION; PYRAZINAMIDE; REVERSED PHASE; RIFAMPICIN;

ACETIC ACID; CHROMATOGRAPHY; ETHANOL; HYDRAZINE; METHANOL; OPTIMIZATION; PH; SEPARATION;

DRUG PRODUCTS;

ACETIC ACID; ALCOHOL; AMMONIA; ETHAMBUTOL; ETHAMBUTOL PLUS ISONIAZID PLUS PYRAZINAMIDE PLUS RIFAMPICIN; ISONIAZID; METHANOL; PROPANOL; PYRAZINAMIDE; RIFAMPICIN; WATER;

ANALYTIC METHOD; ARTICLE; CHEMICAL COMPOSITION; DERIVATIZATION; DRUG STRUCTURE; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; TABLET FORMULATION; ULTRAVIOLET RADIATION;

ANTITUBERCULAR AGENTS; CHROMATOGRAPHY, REVERSE-PHASE; CHROMATOGRAPHY, THIN LAYER; ETHAMBUTOL; ETHANOL; ISONIAZID; PYRAZINAMIDE; REPRODUCIBILITY OF RESULTS; RIFAMPIN; TABLETS;

EID: 84866556260     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.08.044     Document Type: Article

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