Fas ligand regulates the immunomodulatory properties of dental pulp stem cells

Journal of Dental Research

Volumn 91, Issue 10, 2012, Pages 948-954

  Zhao, Y ^a,b   Wang, L ^a,c   Jin, Y ^c   Shi, S ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b XI'AN JIAOTONG UNIVERSITY   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

apoptosis; dental pulp stem cells; differentiation; Fas ligand; immunomodulation; T cells

Indexed keywords

FAS LIGAND;

ANIMAL; APOPTOSIS; ARTICLE; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; COLITIS; CYTOLOGY; FEMALE; GENE SILENCING; HUMAN; IMMUNOLOGY; IMMUNOMODULATION; IMMUNOTHERAPY; METABOLISM; MOUSE; MULTIPOTENT STEM CELL; NUDE MOUSE; PHYSIOLOGY; RAT; RNA INTERFERENCE; SPRAGUE DAWLEY RAT; T LYMPHOCYTE; TOOTH PULP;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELLS, CULTURED; COLITIS; DENTAL PULP; FAS LIGAND PROTEIN; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNOMODULATION; IMMUNOTHERAPY; MICE; MICE, INBRED C57BL; MICE, NUDE; MULTIPOTENT STEM CELLS; RATS; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; T-LYMPHOCYTES;

EID: 84866522872     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034512458690     Document Type: Article

References (26)

1. Akiyama K, Chen C, Wang D, Xu X, Qu C, Yamaza T, et al. Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis. Cell Stem Cell. 2012 ; 10: 544-555
2. Alex P, Zachos NC, Nguyen T, Gonzales L, Chen TE, Conklin LS, et al. Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm Bowel Dis. 2009 ; 15: 341-352
3. Bianco P, Riminucci M, Gronthos S, Robey PG. Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells. 2001 ; 19: 180-192
4. Cappellesso-Fleury S, Puissant-Lubrano B, Apoil PA, Titeux M, Winterton P, Casteilla L, et al. Human fibroblasts share immunosuppressive properties with bone marrow mesenchymal stem cells. J Clin Immunol. 2010 ; 30: 607-619
5. Ding G, Liu Y, An Y, Zhang C, Shi S, Wang W, et al. Suppression of T cell proliferation by root apical papilla stem cells in vitro. Cells Tissues Organs. 2010 ; 191: 357-364
6. Gonzalez-Rey E, Anderson P, Gonzalez MA, Rico L, Buscher D, Delgado M. Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis. Gut. 2009 ; 58: 929-939
7. Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci USA. 2000 ; 97: 13625-13630
8. Halberg N, Wernstedt I, Scherer PE. The adipocyte as an endocrine cell. Endocrinol Metab Clin North Am. 2008 ; 37: 753-768
9. Janebodin K, Horst OV, Ieronimakis N, Balasundaram G, Reesukumal K, Pratumvinit B, et al. Isolation and characterization of neural crest-derived stem cells from dental pulp of neonatal mice. PLoS One. 2011 ; 6: e27526
10. Le Blanc K, Tammik L, Sundberg B, Haynesworth SE, Ringdén O. Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand J Immunol. 2003 ; 57: 11-20
11. Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I, et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet. 2008 ; 371: 1579-1586
12. Lee JH, Lee DS, Nam H, Lee G, Seo BM, Cho YS, et al. Dental follicle cells and cementoblasts induce apoptosis of ameloblast-lineage and Hertwig's epithelial root sheath/epithelial rests of Malassez cells through the Fas-Fas ligand pathway. Eur J Oral Sci. 2012 ; 120: 29-37
13. Mazar J, Thomas M, Bezrukov L, Chanturia A, Pekkurnaz G, Yin S, et al. Cytotoxicity mediated by the Fas ligand (FasL)-activated apoptotic pathway in stem cells. J Biol Chem. 2009 ; 284: 22022-22028
14. Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, et al. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci USA. 2003 ; 100: 5807-5812
15. Morandi F, Raffaghello L, Bianchi G, Meloni F, Salis A, Millo E, et al. Immunogenicity of human mesenchymal stem cells in HLA-class I-restricted T-cell responses against viral or tumorassociated antigens. Stem Cells. 2008 ; 26: 1275-1287
16. Musina RA, Bekchanova ES, Belyavskii AV, Sukhikh GT. Differentiation potential of mesenchymal stem cells of different origin. Bull Exp Biol Med. 2006 ; 141: 147-151
17. O'Reilly LA, Tai L, Lee L, Kruse EA, Grabow S, Fairlie WD, et al. Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature. 2009 ; 461: 659-663
18. Ren G, Zhang L, Zhao X, Xu G, Zhang Y, Roberts AI, et al. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell. 2008 ; 2: 141-150
19. Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 2004 ; 364: 149-155
20. Spaggiari GM, Capobianco A, Abdelrazik H, Becchetti F, Mingari MC, Moretta L. Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2. Blood. 2008 ; 111: 1327-1333
21. Sun L, Akiyama K, Zhang H, Yamaza T, Hou Y, Zhao S, et al. Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans. Stem Cells. 2009 ; 27: 1421-1432
22. Wada N, Menicanin D, Shi S, Bartold PM, Gronthos S. Immunomodulatory properties of human periodontal ligament stem cells. J Cell Physiol. 2009 ; 219: 667-676
23. Yamaza T, Kentaro A, Chen C, Liu Y, Shi Y, Gronthos S, et al. Immunomodulatory properties of stem cells from human exfoliated deciduous teeth. Stem Cell Res Ther. 2010 ; 1: 5
24. Yamaza T, Ren G, Akiyama K, Chen C, Shi Y, Shi S. Mouse mandible contains distinctive mesenchymal stem cells. J Dent Res. 2011 ; 90: 317-324
25. Zhang Q, Shi S, Liu Y, Uyanne J, Shi Y, Le AD. Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis. J Immunol. 2009 ; 183: 7787-7798
26. Zhao S, Wehner R, Bornhauser M, Wassmuth R, Bachmann M, Schmitz M. Immunomodulatory properties of mesenchymal stromal cells and their therapeutic consequences for immune-mediated disorders. Stem Cells Dev. 2010 ; 19: 607-614