Enhanced delivery of gold nanoparticles with therapeutic potential into the brain using MRI-guided focused ultrasound

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 8, Issue 7, 2012, Pages 1133-1142

  Etame, Arnold B ^a   Diaz, Roberto J ^a   O'Reilly, Meaghan A ^b   Smith, Christian A ^a   Mainprize, Todd G ^c   Hynynen, Kullervo ^b   Rutka, James T ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b Sunnybrook Health Sciences Centre   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Blood brain barrier; Central nervous system; Focused ultrasound; Magnetic resonance imaging; Nanoparticles

Indexed keywords

BIODISTRIBUTIONS; BLOOD-BRAIN BARRIER; BRAIN PARENCHYMA; CENTRAL NERVOUS SYSTEMS; DIAGNOSTIC APPLICATIONS; EXPERIMENTAL DIAGNOSTICS; FOCUSED ULTRASOUND; GOLD NANOPARTICLE; GOLD NANOPARTICLES; INTRAVENOUS ADMINISTRATION; NEUROLOGICAL DISEASE; NOVEL TECHNIQUES; RAT MODEL; THERAPEUTIC APPLICATION; THERAPEUTIC POTENTIALS;

BLOOD; DIAGNOSIS; MAGNETIC RESONANCE IMAGING; METAL NANOPARTICLES; NANOPARTICLES; ULTRASONIC APPLICATIONS; ULTRASONICS; VISUALIZATION;

NEUROIMAGING;

GOLD NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CENTRAL NERVOUS SYSTEM; MAGNETIC RESONANCE IMAGING GUIDED FOCUSED ULTRASOUND; NEUROLOGIC DISEASE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARENCHYMA; RAT; ULTRASOUND;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; DRUG DELIVERY SYSTEMS; GOLD; MAGNETIC RESONANCE IMAGING; NANOPARTICLES; RATS; RATS, WISTAR; SOUND;

RATTUS;

EID: 84866508055     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2012.02.003     Document Type: Article

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