Immunohistochemical analysis of polycomb group protein expression in advanced gastric cancer

Human Pathology

Volumn 43, Issue 10, 2012, Pages 1704-1710

  Lee, Hyunjoo ^a   Yoon, Sun Och ^b   Jeong, Woon Yong ^c   Kim, Han Kyeom ^d,e   Kim, Aeree ^d   Kim, Baek Hui ^d,e  

^a Department of Pathology   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c University of Ulsan College of Medicine   (South Korea)

^d Korea University College of Medicine   (South Korea)

^e Korea Human Bio Repositories Network   (South Korea)

Author keywords

BMI 1 (B lymphoma Mo MLV insertion region 1 homolog); DNMT3B (DNA methyltransferase 3B); EZH2 (enhancer of zeste homologue 2); Gastric cancer; Polycomb group proteins; Prognosis

Indexed keywords

BMI1 PROTEIN; DNA METHYLTRANSFERASE 3B; FLUOROURACIL; HISTONE H3; HISTONE H3 LYSINE 27; HYDROXYUREA; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER MORTALITY; CANCER PROGNOSIS; CANCER SURVIVAL; CANCER TISSUE; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; HIGH RISK PATIENT; HISTOLOGY; HISTONE METHYLATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PROTEIN EXPRESSION; SEX DIFFERENCE; STOMACH CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM STAGING; POLYCOMB REPRESSIVE COMPLEX 2; POLYCOMB-GROUP PROTEINS; PROPORTIONAL HAZARDS MODELS; STOMACH NEOPLASMS; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84866503477     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2011.12.019     Document Type: Article

References (32)

1. A. Piunti, and D. Pasini Epigenetic factors in cancer development: polycomb group proteins Future Oncol 7 2011 57 75
2. A.P. Bracken, and K. Helin Polycomb group proteins: navigators of lineage pathways led astray in cancer Nat Rev Cancer 9 2009 773 784
3. D. Martin-Perez, M.A. Piris, and M. Sanchez-Beato Polycomb proteins in hematologic malignancies Blood 116 2010 5465 5475
4. S. Varambally, S.M. Dhanasekaran, and M. Zhou The polycomb group protein EZH2 is involved in progression of prostate cancer Nature 419 2002 624 629
5. G.J. van Leenders, D. Dukers, and D. Hessels Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features Eur Urol 52 2007 455 463 (Pubitemid 46963432)
6. M. Abdouh, S. Facchino, W. Chatoo, V. Balasingam, J. Ferreira, and G. Bernier BMI1 sustains human glioblastoma multiforme stem cell renewal J Neurosci 29 2009 8884 8896
7. M.L. Suva, N. Riggi, and M. Janiszewska EZH2 is essential for glioblastoma cancer stem cell maintenance Cancer Res 69 2009 9211 9218
8. K. Collett, G.E. Eide, and J. Arnes Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer Clin Cancer Res 12 2006 1168 1174 (Pubitemid 43342505)
9. J. Silva, J.M. Garcia, and C. Pena Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas Clin Cancer Res 12 2006 6929 6936 (Pubitemid 44974485)
10. R.H. Breuer, P.J. Snijders, and E.F. Smit Increased expression of the EZH2 polycomb group gene in BMI-1-positive neoplastic cells during bronchial carcinogenesis Neoplasia 6 2004 736 743 (Pubitemid 40041491)
11. M. Sasaki, H. Ikeda, and K. Itatsu The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma Lab Invest 88 2008 873 882
12. G.H. Cai, K. Wang, Q. Miao, Y.S. Peng, and X.Y. Chen Expression of polycomb protein EZH2 in multi-stage tissues of gastric carcinogenesis J Dig Dis 11 2010 88 93
13. W. Li, Y. Li, Y. Tan, K. Ma, and J. Cui Bmi-1 is critical for the proliferation and invasiveness of gastric carcinoma cells J Gastroenterol Hepatol 25 2010 568 575
14. K. Mimori, K. Ogawa, M. Okamoto, T. Sudo, H. Inoue, and M. Mori Clinical significance of enhancer of zeste homolog 2 expression in colorectal cancer cases Eur J Surg Oncol 31 2005 376 380 (Pubitemid 40521303)
15. S. Weikert, F. Christoph, and J. Kollermann Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas Int J Mol Med 16 2005 349 353
16. S. Hinz, S. Weikert, and A. Magheli Expression profile of the polycomb group protein enhancer of zeste homologue 2 and its prognostic relevance in renal cell carcinoma J Urol 182 2009 2920 2925
17. A.M. Pietersen, H.M. Horlings, and M. Hauptmann EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer Breast Cancer Res 10 2008 R109
18. O. Fluge, K. Gravdal, and E. Carlsen Expression of EZH2 and Ki-67 in colorectal cancer and associations with treatment response and prognosis Br J Cancer 101 2009 1282 1289
19. I.M. Bachmann, H.E. Puntervoll, A.P. Otte, and L.A. Akslen Loss of BMI-1 expression is associated with clinical progress of malignant melanoma Mod Pathol 21 2008 583 590 (Pubitemid 351589652)
20. J. Xiao, and C. Deng Knockdown of Bmi-1 impairs growth and invasiveness of human gastric carcinoma cells Oncol Res 17 2009 613 620
21. X.W. Zhang, Y.P. Sheng, and Q. Li BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer Mol Cancer 9 2010 40
22. J.H. Liu, L.B. Song, and X. Zhang Bmi-1 expression predicts prognosis for patients with gastric carcinoma J Surg Oncol 97 2008 267 272 (Pubitemid 351312168)
23. J. Zhao, X.D. Luo, C.L. Da, and Y. Xin Clinicopathological significance of B-cell-specific Moloney murine leukemia virus insertion site 1 expression in gastric carcinoma and its precancerous lesion World J Gastroenterol 15 2009 2145 2150
24. J.H. Choi, Y.S. Song, J.S. Yoon, K.W. Song, and Y.Y. Lee Enhancer of zeste homolog 2 expression is associated with tumor cell proliferation and metastasis in gastric cancer APMIS 118 2010 196 202
25. Y. Matsukawa, S. Semba, H. Kato, A. Ito, K. Yanagihara, and H. Yokozaki Expression of the enhancer of zeste homolog 2 is correlated with poor prognosis in human gastric cancer Cancer Sci 97 2006 484 491 (Pubitemid 43811589)
26. S.B. Edge, and American Joint Committee on Cancer AJCC cancer staging manual 7th ed. 2010 Springer New York
27. L.A. Aaltonen, and S.R. Hamilton World Health Organization., International Agency for Research on Cancer. Pathology and genetics of tumours of the digestive system 2000 IARC Press Lyon Oxford
28. X. Su, C. Lv, and F. Qiao Expression pattern and clinical significance of DNA methyltransferase 3B variants in gastric carcinoma Oncol Rep 23 2010 819 826
29. W.J. Ding, J.Y. Fang, X.Y. Chen, and Y.S. Peng The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer Dig Dis Sci 53 2008 2083 2089
30. J. Yu, J. Yu, and R.S. Mani An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression Cancer Cell 17 2010 443 454
31. J.C. Zhao, J. Yu, and C. Runkle Cooperation between polycomb and androgen receptor during oncogenic transformation Genome Res 2011 [Epub ahead of print]
32. I.B. Engelsen, M. Mannelqvist, and I.M. Stefansson Low BMI-1 expression is associated with an activated BMI-1-driven signature, vascular invasion, and hormone receptor loss in endometrial carcinoma Br J Cancer 98 2008 1662 1669 (Pubitemid 351684686)