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Volumn 101, Issue 8, 2009, Pages 1282-1289

Expression of EZH2 and Ki-67 in colorectal cancer and associations with treatment response and prognosis

Author keywords

Adjuvant chemotherapy; Colorectal cancer; EZH2; Immunehistochemistry; Ki 76; Prediction of outcome

Indexed keywords

ENHANCER OF ZESTE HOMOLOG 2 PROTEIN; FLUOROURACIL; KI 67 ANTIGEN; LEVAMISOLE; POLYCOMB GROUP PROTEIN; UNCLASSIFIED DRUG;

EID: 70349958032     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6605333     Document Type: Article
Times cited : (129)

References (19)
  • 1
    • 0037440051 scopus 로고    scopus 로고
    • Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: A National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study
    • Allegra CJ, Paik S, Colangelo LH, Parr AL, Kirsch I, Kim G, Klein P, Johnston PG, Wolmark N, Wieand HS (2003) Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study. J Clin Oncol 21: 241-250
    • (2003) J Clin Oncol , vol.21 , pp. 241-250
    • Allegra, C.J.1    Paik, S.2    Colangelo, L.H.3    Parr, A.L.4    Kirsch, I.5    Kim, G.6    Klein, P.7    Johnston, P.G.8    Wolmark, N.9    Wieand, H.S.10
  • 3
    • 67349148275 scopus 로고    scopus 로고
    • Proliferation is the strongest prognosticator in node-negative breast cancer: Significance, error sources, alternatives and comparison with molecular prognostic markers
    • Baak JP, Gudlaugsson E, Skaland I, Guo LH, Klos J, Lende TH, Soiland H, Janssen EA, Zur Hausen A (2009) Proliferation is the strongest prognosticator in node-negative breast cancer: significance, error sources, alternatives and comparison with molecular prognostic markers. Breast Cancer Res Treat 115: 241-254
    • (2009) Breast Cancer Res Treat , vol.115 , pp. 241-254
    • Baak, J.P.1    Gudlaugsson, E.2    Skaland, I.3    Guo, L.H.4    Klos, J.5    Lende, T.H.6    Soiland, H.7    Janssen, E.A.8    Zur Hausen, A.9
  • 4
    • 33644822360 scopus 로고    scopus 로고
    • EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
    • Bachmann IM, Halvorsen OJ, Collett K, Stefansson IM, Straume O, Haukaas SA, Salvesen HB, Otte AP, Akslen LA (2006) EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J Clin Oncol 24: 268-273
    • (2006) J Clin Oncol , vol.24 , pp. 268-273
    • Bachmann, I.M.1    Halvorsen, O.J.2    Collett, K.3    Stefansson, I.M.4    Straume, O.5    Haukaas, S.A.6    Salvesen, H.B.7    Otte, A.P.8    Akslen, L.A.9
  • 5
    • 0142105414 scopus 로고    scopus 로고
    • EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
    • Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K (2003) EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J 22: 5323-5335
    • (2003) EMBO J , vol.22 , pp. 5323-5335
    • Bracken, A.P.1    Pasini, D.2    Capra, M.3    Prosperini, E.4    Colli, E.5    Helin, K.6
  • 6
    • 0036153461 scopus 로고    scopus 로고
    • Ki67 protein: The immaculate deception?
    • Brown DC, Gatter KC (2002) Ki67 protein: the immaculate deception? Histopathology 40: 2-11
    • (2002) Histopathology , vol.40 , pp. 2-11
    • Brown, D.C.1    Gatter, K.C.2
  • 7
  • 8
    • 0030588658 scopus 로고    scopus 로고
    • Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2
    • Chen H, Rossier C, Antonarakis SE (1996) Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2. Genomics 38: 30-37
    • (1996) Genomics , vol.38 , pp. 30-37
    • Chen, H.1    Rossier, C.2    Antonarakis, S.E.3
  • 9
    • 33644765912 scopus 로고    scopus 로고
    • Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer
    • Collett K, Eide GE, Arnes J, Stefansson IM, Eide J, Braaten A, Aas T, Otte AP, Akslen LA (2006) Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer. Clin Cancer Res 12: 1168-1174
    • (2006) Clin Cancer Res , vol.12 , pp. 1168-1174
    • Collett, K.1    Eide, G.E.2    Arnes, J.3    Stefansson, I.M.4    Eide, J.5    Braaten, A.6    Aas, T.7    Otte, A.P.8    Akslen, L.A.9
  • 10
    • 65349164596 scopus 로고    scopus 로고
    • Final results of a randomised phase III study on adjuvant chemotherapy with 5 FU and levamisol in colon and rectum cancer stage II and III by the Norwegian Gastrointestinal Cancer Group
    • Norwegian Gastrointestinal Cancer Group
    • Dahl O, Fluge O, Carlsen E, Wiig JN, Myrvold HE, Vonen B, Podhorny N, Bjerkeset O, Eide TJ, Halvorsen TB, Tveit KM, Norwegian Gastrointestinal Cancer Group (2009) Final results of a randomised phase III study on adjuvant chemotherapy with 5 FU and levamisol in colon and rectum cancer stage II and III by the Norwegian Gastrointestinal Cancer Group. Acta Oncol 48: 368-376
    • (2009) Acta Oncol , vol.48 , pp. 368-376
    • Dahl, O.1    Fluge, O.2    Carlsen, E.3    Wiig, J.N.4    Myrvold, H.E.5    Vonen, B.6    Podhorny, N.7    Bjerkeset, O.8    Eide, T.J.9    Halvorsen, T.B.10    Tveit, K.M.11
  • 12
    • 0033630844 scopus 로고    scopus 로고
    • Clinical significance of MUC1 and E-cadherin expression, cellular proliferation, and angiogenesis at the deepest invasive portion of colorectal cancer
    • Kimura T, Tanaka S, Haruma K, Sumii K, Kajiyama G, Shimamoto F, Kohno N (2000) Clinical significance of MUC1 and E-cadherin expression, cellular proliferation, and angiogenesis at the deepest invasive portion of colorectal cancer. Int J Oncol 16: 55-64
    • (2000) Int J Oncol , vol.16 , pp. 55-64
    • Kimura, T.1    Tanaka, S.2    Haruma, K.3    Sumii, K.4    Kajiyama, G.5    Shimamoto, F.6    Kohno, N.7
  • 15
    • 0032904651 scopus 로고    scopus 로고
    • Low tumour cell proliferation at the invasive margin is associated with a poor prognosis in Dukes' stage B colorectal cancers
    • Palmqvist R, Sellberg P, Oberg A, Tavelin B, Rutegard JN, Stenling R (1999) Low tumour cell proliferation at the invasive margin is associated with a poor prognosis in Dukes' stage B colorectal cancers. Br J Cancer 79: 577-581
    • (1999) Br J Cancer , vol.79 , pp. 577-581
    • Palmqvist, R.1    Sellberg, P.2    Oberg, A.3    Tavelin, B.4    Rutegard, J.N.5    Stenling, R.6
  • 16
    • 22144443169 scopus 로고    scopus 로고
    • Increased proliferation activity measured by immunoreactive Ki67 is associated with survival improvement in rectal/recto sigmoid cancer
    • Salminen E, Palmu S, Vahlberg T, Roberts PJ, Soderstrom KO (2005) Increased proliferation activity measured by immunoreactive Ki67 is associated with survival improvement in rectal/recto sigmoid cancer. World J Gastroenterol 11: 3245-3249
    • (2005) World J Gastroenterol , vol.11 , pp. 3245-3249
    • Salminen, E.1    Palmu, S.2    Vahlberg, T.3    Roberts, P.J.4    Soderstrom, K.O.5
  • 18
    • 0032751323 scopus 로고    scopus 로고
    • Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation
    • Van der Vlag J, Otte AP (1999) Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. Nat Genet 23: 474-478
    • (1999) Nat Genet , vol.23 , pp. 474-478
    • Van Der Vlag, J.1    Otte, A.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.