A toxicologic and dermatologic assessment of cyclopentanones and cyclopentenones when used as fragrance ingredients

Food and Chemical Toxicology

Volumn 50, Issue SUPPL.3, 2012, Pages

  Belsito, D ^a   Bickers, D ^a   Bruze, M ^b   Calow, P ^c   Dagli, M L ^d   Dekant, W ^e   Fryer, A D ^f   Greim, H ^g   Miyachi, Y ^h   Saurat, J H ⁱ   Sipes, I G ^j  

^a Department of Medicine   (United States)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

^e UNIVERSITY OF WÜRZBURG   (Germany)

^f OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^g TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^h KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

ⁱ UNIVERSITY OF GENEVA   (Switzerland)

^j UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

more..

Author keywords

Cyclopentanones; Cyclopentenones; Fragrance material; Group summary; Ketones; Review

Indexed keywords

2 (3,7 DIMETHYL 2,6 OCTADIENYL)CYCLOPENTANONE; 2 (4 MENTH 1 ENE 10 YL)CYCLOPENTANONE; 2 CYCLOPENTYLCYCLOPENTANONE; 2 HEPTYLCYCLOPENTANONE; 2 HEPTYLIDENECYCLOPENTAN 1 ONE; 2 HEXYLCYCLOPENTANONE; 2 HEXYLIDENE CYCLOPENTANONE; 2 HYDROXY 3,4 DIMETHYL 2 CYCLOPENTEN 1 ONE; 2 PENTYLCYCLOPENTAN 1 ONE; 2 PENTYLIDENE CYCLOPENTANONE; 2,2,5 TRIMETHYL 5 PENTYLCYCLOPENTANONE; 3 ETHYL 2 HYDROXY 2 CYCLOPENTEN 1 ONE; 3 METHYL 2 (2 PENTANYL) 2 CYCLOPENTEN 1 ONE; 3 METHYL 2 (N PENTANYL) 2 CYCLOPENTEN 1 ONE; 3 METHYL 2 (PENTOXYL) 2 CYCLOPENTEN 1 ONE; 3 METHYL 2 PENTYLCYCLOPENTAN 1 ONE; AMYLCYCLOPENTANONE; CIS JASMONE; CYCLOPENTANONE DERIVATIVE; CYCLOPENTENONE DERIVATIVE; CYCLOTENE PROPIONATE; DIHYDROISOJASMONE; FRAGRANCE; HEXENYLCYCLOPENTANONE; ISOJASMONE; METHYL 3 OXO 2 (PENT 2 ENYL)CYCLOPENTANEACETATE; METHYL DIHYDROJASMONATE; METHYL HEXYL OXO CYCLOPENTANONE CARBOXYLATE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; CARCINOGENICITY; CELL ASSAY; CHEMICAL ANALYSIS; CONCENTRATION (PARAMETERS); CYTOTOXICITY TEST; DEVELOPMENTAL TOXICITY; EYE IRRITATION; GENOTOXICITY; HUMAN; IN VITRO STUDY; LD 50; MATERIALS TESTING; METABOLITE; MUCOSAL DISEASE; NONHUMAN; PHOTOSENSITIZATION; PHOTOTOXICITY; PRODUCT SAFETY; REVIEW; RISK ASSESSMENT; SKIN EXAMINATION; SKIN IRRITATION; SKIN SENSITIZATION; SKIN TOXICITY; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS; TOXICITY TESTING; TOXICOKINETICS;

ANIMALS; CYCLOPENTANES; HUMANS; PERFUME; SKIN; TOXICITY TESTS;

MAMMALIA;

EID: 84866454951     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.04.019     Document Type: Review

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111. RIFM (Research Institute for Fragrance Materials, Inc.), 1980h. Report on human maximization study. RIFM report number 1790, November 07. RIFM, Woodcliff Lake, NJ, USA.
112. RIFM (Research Institute for Fragrance Materials, Inc.), 1980i. Repeated insult patch test/Photosensitization study in human subjects. Unpublished report from Firmenich, Inc., June 20. Report number 38756. RIFM, Woodcliff Lake, NJ, USA.
113. RIFM (Research Institute for Fragrance Materials, Inc.), 1980j. Rabbit covered patch skin irritation test. Unpublished report from Proprietary Perfumes Ltd., UK, August 15. Report number 46131. RIFM, Woodcliff Lake, NJ, USA.
114. RIFM (Research Institute for Fragrance Materials, Inc.), 1980k. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, October 8. Report number 46130. RIFM, Woodcliff Lake, NJ, USA.
115. RIFM (Research Institute for Fragrance Materials, Inc.), 1980l. Covered patch preliminary irritation test. Unpublished report from Proprietary Perfumes Ltd., UK, August 15. Report number 46137. RIFM, Woodcliff Lake, NJ, USA.
116. RIFM (Research Institute for Fragrance Materials, Inc.), 1980m. Rabbit covered patch test. Unpublished report from Proprietary Perfumes Ltd., UK, March 6. Report number 46302. RIFM, Woodcliff Lake, NJ, USA.
117. RIFM (Research Institute for Fragrance Materials, Inc.), 1980n. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, not dated. Report number 46288. RIFM, Woodcliff Lake, NJ, USA.
118. RIFM (Research Institute for Fragrance Materials, Inc.), 1980o. Phototoxicity test topical application method. Unpublished report from Proprietary Perfumes Ltd., UK, May 27. Report number 46309. RIFM, Woodcliff Lake, NJ, USA.
119. RIFM (Research Institute for Fragrance Materials, Inc.), 1980p. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, February 15. Report number 46945. RIFM, Woodcliff Lake, NJ, USA.
120. RIFM (Research Institute for Fragrance Materials, Inc.), 1980q. Primary skin irritation study - rabbits. Unpublished report from Firmenich, Inc., April 21. Report number 38754. RIFM, Woodcliff Lake, NJ, USA.
121. RIFM (Research Institute for Fragrance Materials, Inc.), 1980r. Rat open application skin irritation test. Unpublished report from Proprietary Perfumes Ltd., UK, September 23. Report number 45420. RIFM, Woodcliff Lake, NJ, USA.
122. RIFM (Research Institute for Fragrance Materials, Inc.), 1980s. Rabbit eye irritation test. Unpublished report from Proprietary Perfumes Ltd., UK, September 1. Report number 46129. RIFM, Woodcliff Lake, NJ, USA.
123. RIFM (Research Institute for Fragrance Materials, Inc.), 1980t. Rabbit eye irritation test. Unpublished report from Proprietary Perfumes Ltd., UK, September 2. Report number 46128. RIFM, Woodcliff Lake, NJ, USA.
124. RIFM (Research Institute for Fragrance Materials, Inc.), 1980u. Rabbit eye irritation test. Unpublished report from Proprietary Perfumes Ltd., UK, September 1. Report number 46127. RIFM, Woodcliff Lake, NJ, USA.
125. RIFM (Research Institute for Fragrance Materials, Inc.), 1980v. Rabbit eye irritation test. Unpublished report from Proprietary Perfumes Ltd., UK, September 1. Report number 46136. RIFM, Woodcliff Lake, NJ, USA.
126. RIFM (Research Institute for Fragrance Materials, Inc.), 1980w. Rabbit eye irritation test. Unpublished report from Proprietary Perfumes Ltd., UK, September 2. Report number 46135. RIFM, Woodcliff Lake, NJ, USA.
127. RIFM (Research Institute for Fragrance Materials, Inc.), 1980x. Rabbit eye irritation test. Unpublished report from Proprietary Perfumes Ltd., UK, September 2. Report number 46134. RIFM, Woodcliff Lake, NJ, USA.
128. RIFM (Research Institute for Fragrance Materials, Inc.), 1980y. Rabbit eye irritation test. Unpublished report from Proprietary Perfumes Ltd., UK, April 11. Report number 46303. RIFM, Woodcliff Lake, NJ, USA.
129. RIFM (Research Institute for Fragrance Materials, Inc.), 1980z. Rabbit eye irritation test - screen test. Unpublished report from Proprietary Perfumes Ltd., UK, April 10. Report number 46304. RIFM, Woodcliff Lake, NJ, USA.
130. RIFM (Research Institute for Fragrance Materials, Inc.), 1980aa. Rabbit eye irritation test - screen test. Unpublished report from Proprietary Perfumes Ltd., UK, April 10. Report number 46305. RIFM, Woodcliff Lake, NJ, USA.
131. RIFM (Research Institute for Fragrance Materials, Inc.), 1980bb. Primary eye irritation study - rabbits. Unpublished report from Firmenich, Inc., April 21. Report number 38755. RIFM, Woodcliff Lake, NJ, USA.
132. RIFM (Research Institute for Fragrance Materials, Inc.), 1981a. Acute dermal toxicity - rabbits. Unpublished report from Firmenich, Inc., April 10. Report number 38842. RIFM, Woodcliff Lake, NJ, USA.
133. RIFM (Research Institute for Fragrance Materials, Inc.), 1981b. Acute oral toxicity - rats. Unpublished report from Firmenich, Inc., April 10. Report number 38841. RIFM, Woodcliff Lake, NJ, USA.
134. RIFM (Research Institute for Fragrance Materials, Inc.), 1981c. Report on human maximization study. RIFM report number 1792, March 18. RIFM, Woodcliff Lake, NJ, USA.
135. RIFM (Research Institute for Fragrance Materials, Inc.), 1981d. Repeated insult patch test/Photosensitization study in human subjects. Unpublished report from Firmenich, Inc., May 20. Report number 38845. RIFM, Woodcliff Lake, NJ, USA.
136. RIFM (Research Institute for Fragrance Materials, Inc.), 1981e. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, March 13. Report number 46301. RIFM, Woodcliff Lake, NJ, USA.
137. RIFM (Research Institute for Fragrance Materials, Inc.), 1981f. Primary skin irritation - rabbits. Unpublished report from Firmenich, Inc., April 10. Report number 38843. RIFM, Woodcliff Lake, NJ, USA.
138. RIFM (Research Institute for Fragrance Materials, Inc.), 1981g. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, October 22. Report number 46449. RIFM, Woodcliff Lake, NJ, USA.
139. RIFM (Research Institute for Fragrance Materials, Inc.), 1981h. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, June 23. Report number 46467. RIFM, Woodcliff Lake, NJ, USA.
140. RIFM (Research Institute for Fragrance Materials, Inc.), 1981i. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, May 8. Report number 46946. RIFM, Woodcliff Lake, NJ, USA.
141. RIFM (Research Institute for Fragrance Materials, Inc.), 1981j. Primary eye irritation - rabbits. Unpublished report from Firmenich, Inc., April 10. Report number 38844. RIFM, Woodcliff Lake, NJ, USA.
142. RIFM (Research Institute for Fragrance Materials, Inc.), 1982a. Acute toxicity studies with rats, rabbits, guinea pigs. Unpublished report from Esso Research and Engineering Company, August 10. Report number 16465. RIFM, Woodcliff Lake, NJ, USA.
143. RIFM (Research Institute for Fragrance Materials, Inc.), 1982b. Acute oral toxicity test. Unpublished report from Proprietary Perfumes Ltd., UK, April 6. Report number 46183. RIFM, Woodcliff Lake, NJ, USA.
144. RIFM (Research Institute for Fragrance Materials, Inc.), 1982c. LC50 determination - acute inhalation exposure. Unpublished report from Esso Research and Engineering Company, January 15. Report number 16464. RIFM, Woodcliff Lake, NJ, USA.
145. RIFM (Research Institute for Fragrance Materials, Inc.), 1982d. Repeated insult patch test of 2-hexylidene cyclopentanone. Unpublished report from International Flavors and Fragrances, Inc., July 21. Report number 15002. RIFM, Woodcliff Lake, NJ, USA.
146. RIFM (Research Institute for Fragrance Materials, Inc.), 1982e. Phototoxicity test topical application method. Unpublished report from Proprietary Perfumes Ltd., UK, February 15. Report number 49265. RIFM, Woodcliff Lake, NJ, USA.
147. RIFM (Research Institute for Fragrance Materials, Inc.), 1982f. Rabbit covered patch skin irritation test. Unpublished report from Proprietary Perfumes Ltd., UK, May 18. Report number 46182. RIFM, Woodcliff Lake, NJ, USA.
148. RIFM (Research Institute for Fragrance Materials, Inc.), 1982g. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, April 29. Report number 46187. RIFM, Woodcliff Lake, NJ, USA.
149. RIFM (Research Institute for Fragrance Materials, Inc.), 1982h. Phototoxicity test topical application method. Unpublished report from Proprietary Perfumes Ltd., UK, July 12. Report number 46184. RIFM, Woodcliff Lake, NJ, USA.
150. RIFM (Research Institute for Fragrance Materials, Inc.), 1982i. Magnusson and Kligman guinea pig maximization test. Unpublished report from Proprietary Perfumes Ltd., UK, January 19. Report number 15008. RIFM, Woodcliff Lake, NJ, USA.
151. RIFM (Research Institute for Fragrance Materials, Inc.), 1982j. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, February 19. Report number 46292. RIFM, Woodcliff Lake, NJ, USA.
152. RIFM (Research Institute for Fragrance Materials, Inc.), 1982k. Sensitization test with isojasmon pure in guinea pigs (maximization test). Unpublished report from International Fragrance Association (IFRA), CH, April. Report number 15007. RIFM, Woodcliff Lake, NJ, USA.
153. RIFM (Research Institute for Fragrance Materials, Inc.), 1982l. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, September 10. Report number 46466. RIFM, Woodcliff Lake, NJ, USA.
154. RIFM (Research Institute for Fragrance Materials, Inc.), 1982m. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, June 17. Report number 46469. RIFM, Woodcliff Lake, NJ, USA.
155. RIFM (Research Institute for Fragrance Materials, Inc.), 1982n. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, October 19. Report number 46471. RIFM, Woodcliff Lake, NJ, USA.
156. RIFM (Research Institute for Fragrance Materials, Inc.), 1982o. Rabbit eye irritation test - small volume test. Unpublished report from Proprietary Perfumes Ltd., UK, June 14. Report number 46185. RIFM, Woodcliff Lake, NJ, USA.
157. RIFM (Research Institute for Fragrance Materials, Inc.), 1982p. Rabbit eye irritation test - screen test. Unpublished report from Proprietary Perfumes Ltd., UK, May 14. Report number 46186. RIFM, Woodcliff Lake, NJ, USA.
158. RIFM (Research Institute for Fragrance Materials, Inc.), 1982q. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, November 18. Report number 46177. RIFM, Woodcliff Lake, NJ, USA.
159. RIFM (Research Institute for Fragrance Materials, Inc.), 1982r. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, February 19. Report number 46294. RIFM, Woodcliff Lake, NJ, USA.
160. RIFM (Research Institute for Fragrance Materials, Inc.), 1982s. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, February 19. Report number 46293. RIFM, Woodcliff Lake, NJ, USA.
161. RIFM (Research Institute for Fragrance Materials, Inc.), 1983a. Acute toxicity study in mice. Unpublished report from Givaudan Forschungsgesellschaft AG, January. Report number 9020 (German). RIFM, Woodcliff Lake, NJ, USA.
162. RIFM (Research Institute for Fragrance Materials, Inc.), 1983b. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, February 25. Report number 46178. RIFM, Woodcliff Lake, NJ, USA.
163. RIFM (Research Institute for Fragrance Materials, Inc.), 1983c. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, February 25. Report number 46179. RIFM, Woodcliff Lake, NJ, USA.
164. RIFM (Research Institute for Fragrance Materials, Inc.), 1983d. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, February 25. Report number 46180. RIFM, Woodcliff Lake, NJ, USA.
165. RIFM (Research Institute for Fragrance Materials, Inc.) 1983e. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, February 25. Report number 46188. RIFM, Woodcliff Lake, NJ, USA.
166. RIFM (Research Institute for Fragrance Materials, Inc.), 1983f. Guinea pig skin sensitization test. Unpublished report from Proprietary Perfumes Ltd., UK, February 22. Report number 46295. RIFM, Woodcliff Lake, NJ, USA.
167. RIFM (Research Institute for Fragrance Materials, Inc.), 1984a. Determination of phototoxicity in guinea pigs. Unpublished report from Givaudan Vernier. August 2. Report number 17957. RIFM, Woodcliff Lake, NJ, USA.
168. RIFM (Research Institute for Fragrance Materials, Inc.), 1984b. Determination of photoallergenicity in guinea pigs. Unpublished report from Givaudan Vernier. September 19. Report number 17956. RIFM, Woodcliff Lake, NJ, USA.
169. RIFM (Research Institute for Fragrance Materials, Inc.), 1985a. Determination of skin irritation and capacity of allergenic sensitization by the open epicutanous test on guinea pigs (OET) with hexylidene cyclopentanone. RIFM report number 6068, December 30. RIFM, Woodcliff Lake, NJ, USA.
170. RIFM (Research Institute for Fragrance Materials, Inc.), 1985b. Delayed contact hypersensitivity study in guinea pigs of alpha-hexylidene cyclopentanone. RIFM report number 4472, October 25. RIFM, Woodcliff Lake, NJ, USA.
171. RIFM (Research Institute for Fragrance Materials, Inc.), 1985c. Closed epicutaneous test in guinea pigs of 2-hexylidene cyclopentanone. RIFM report number 4474, October 25. RIFM, Woodcliff Lake, NJ, USA.
172. RIFM (Research Institute for Fragrance Materials, Inc.), 1985d. Closed epicutaneous test in guinea pigs of alpha-hexylidene cyclopentanone. RIFM report number 5175, December 30. RIFM, Woodcliff Lake, NJ, USA.
173. RIFM (Research Institute for Fragrance Materials, Inc.), 1986a. Acute oral toxicity to rats of methyl dihydrojasmonate. Unpublished report from Unilever Research, UK, January 5. Report number 46470. RIFM, Woodcliff Lake, NJ, USA.
174. RIFM (Research Institute for Fragrance Materials, Inc.), 1986b. Delayed contact hypersensitivity study in guinea pigs of alpha-hexylidene cyclopentanone. RIFM report number 4470, February 21. RIFM, Woodcliff Lake, NJ, USA.
175. RIFM (Research Institute for Fragrance Materials, Inc.), 1986c. Skin sensitization study. Unpublished report from Proprietary Perfumes Ltd., UK, February 12. Report number 46478. RIFM, Woodcliff Lake, NJ, USA.
176. RIFM (Research Institute for Fragrance Materials, Inc.), 1986d. Rabbit covered patch skin irritation test. Unpublished report from Proprietary Perfumes Ltd., UK, October 3. Report number 46473. RIFM, Woodcliff Lake, NJ, USA.
177. RIFM (Research Institute for Fragrance Materials, Inc.), 1986e. The rabbit eye irritation test. Unpublished report from Proprietary Perfumes Ltd., UK, September 1. Report number 46476. RIFM, Woodcliff Lake, NJ, USA.
178. RIFM (Research Institute for Fragrance Materials, Inc.), 1986f. The rabbit eye irritation test. Unpublished report from Proprietary Perfumes Ltd., UK, September 25. Report number 46477. RIFM, Woodcliff Lake, NJ, USA.
179. RIFM (Research Institute for Fragrance Materials, Inc.), 1987a. A bacterial mutation study on methyl dihydrojasmonate. Unpublished report from Unilever Research, UK, November 19. Report number 4647. RIFM, Woodcliff Lake, NJ, USA.
180. RIFM (Research Institute for Fragrance Materials, Inc.), 1987b. Acute dermal irritation study. RIFM report number 5667, August. RIFM, Woodcliff Lake, NJ, USA.
181. RIFM (Research Institute for Fragrance Materials, Inc.), 1988. Analysis of metaphase chromosomes obtained from CHO cells cultured in vitro and treated with methyl dihydrojasmonate. Unpublished report from Unilever Research, UK, October 6. Report number 46492. RIFM, Woodcliff Lake, NJ, USA.
182. RIFM (Research Institute for Frangrance Materials, Inc.), 1989a. Test to evaluate the acute toxicity following a single cutaneous application of 2-(p-menth-1-ene-10-yl)cyclopentanone (nectaryl) in the rat. Unpublished report from Givaudon, September 11. Report number 56782. RIFM, Woodcliff Lake, NJ, USA.
183. RIFM (Research Institute for Fragrance Materials, Inc.), 1989b. AC Test to evaluate the acute toxicity following a single oral application of 2-(p-menth-1-ene-10-yl)cyclopentanone (nectarly) in the rat. Unpublished report from Givaudon, September 11. Report number 56783. RIFM, Woodcliff Lake, NJ, USA.
184. RIFM (Research Institute for Fragrance Materials, Inc.), 1989c. 4-Week dermal toxicity study in the rat with 2-(p-menth-1-ene-10-yl)cyclopentanone (nectaryl). Unpublished report from Givaudon, September 12. Report number 56771. RIFM, Woodcliff Lake, NJ, USA.
185. RIFM (Research Institute for Fragrance Materials, Inc.), 1989d. Salmonella typhimurium/mammalian microsome plate incorporation assay (Ames Test) using 2-(p-menth-1-ene-10-yl)cyclopentanone. Unpublished report from Givaudon. September 21. Report number 41332. RIFM, Woodcliff Lake, NJ, USA.
186. RIFM (Research Institute for Fragrance Materials, Inc.), 1989e. Micronucleus test in the mouse with 2-(p-menth-1-ene-10-yl)cyclopentanone (nectaryl). Unpublished report from Givaudon, October 12. Report number 56774. RIFM, Woodcliff Lake, NJ, USA.
187. RIFM (Research Institute for Fragrance Materials, Inc.), 1989f. 2-(p-Menth-1-ene-10-yl)cyclopentanone (Nectarly): Test to evaluate the acute primary cutaneous irritation and corrosivity in the rabbit, the acute ocular irritation and reversibility in the rabbit, and the sensitizing potential in the guinea-pig. Unpublished report from Givaudon, September 25. Report number 56787. RIFM, Woodcliff Lake, NJ, USA.
188. RIFM (Research Institute for Fragrance Materials, Inc.), 1991a. 2-(3,7-Dimethyl-2,6-octadienyl)cyclopentanone - acute oral toxicity, single level - rats (FHSA). Unpublished report from Bedoukian Research, June 13. Report number 17236. RIFM, Woodcliff Lake, NJ, USA.
189. RIFM (Research Institute for Fragrance Materials, Inc.), 1991b. Guinea pig sensitization - modified Buehler method. Unpublished report from Bedoukian Research, January 9. Report number 17237. RIFM, Woodcliff Lake, NJ, USA.
190. RIFM (Research Institute for Fragrance Materials, Inc.), 1991c. 2-(3,7-Dimethyl-2,6-octadienyl)cyclopentanone - Primary skin irritation - rabbits. Unpublished report from Bedoukian Research, June 14. Report number 17235. RIFM, Woodcliff Lake, NJ, USA.
191. RIFM (Research Institute for Fragrance Materials, Inc.), 1996. Repeat insult patch test with 2-(p-menth-1-ene-10-yl)cyclopentanone (nectaryl). Unpublished report from Givaudon, July 3. Report number 56778. RIFM, Woodcliff Lake, NJ, USA.
192. RIFM (Research Institute for Fragrance Materials, Inc.), 1998. Mammalian erythrocyte micronucleus test. Unpublished report from Firmenich, Inc., August 4. Report number 33615. RIFM, Woodcliff Lake, NJ, USA.
193. RIFM (Research Institute for Fragrance Materials, Inc.), 2000a. Methyl dihydrojasmonate: a 14-day dietary range-finding toxicity study in rats. Unpublished report from Firmenich, Inc., January 20. Report number 37008. RIFM, Woodcliff Lake, NJ, USA.
194. RIFM (Research Institute for Fragrance Materials, Inc.), 2000b. Methyl dihydrojasmonate: a 3-month dietary toxicity study in rats. Unpublished report from Firmenich, Inc., December 15. Report number 37009. RIFM, Woodcliff Lake, NJ, USA.
195. RIFM (Research Institute for Fragrance Materials, Inc.), 2000c. Mutagenicity study with 2-heptylcyclopentanone (projasmon) in Salmonella typhimurium/mammalian microsome reverse mutation assay. Unpublished report from Symrise, Inc., August 31. Report number 54864. RIFM, Woodcliff Lake, NJ, USA.
196. RIFM (Research Institute for Fragrance Materials, Inc.), 2000d. Methyl dihydrojasmonate: Bacterial reverse mutation assay. Unpublished report from Firmenich, Inc., August 28. Report number 37011. RIFM, Woodcliff Lake, NJ, USA.
197. RIFM (Research Institute for Fragrance Materials, Inc.), 2000e. Methyl dihydrojasmonate: reverse mutation assay "Ames test" using Salmonella typhimurium. Unpublished report from Firmenich, Inc., October 11. Report number 37012. RIFM, Woodcliff Lake, NJ, USA.
198. RIFM (Research Institute for Fragrance Materials, Inc.), 2000f. Methyl dihydrojasmonate: primary eye irritation (OECD 405). Unpublished report from Firmenich, Inc., May 31. Report number 37010. RIFM, Woodcliff Lake, NJ, USA.
199. RIFM (Research Institute for Fragrance Materials, Inc.), 2000g. Repeated insult patch test with 3-ethyl-2-hydroxy-2-cyclopenten-1-one (ethyl cyclotene). Unpublished report from International Flavors and Fragrances, Inc., July 20. Report number 53943. RIFM, Woodcliff Lake, NJ, USA.
200. RIFM (Research Institute for Fragrance Materials, Inc.), 2001a. In vitro human skin permeation of three radiolabelled fragrance materials. RIFM report number 37083, January 4. RIFM, Woodcliff Lake, NJ, USA.
201. RIFM (Research Institute for Fragrance Materials, Inc.), 2001b. Methyl dihydrojasmonate: in vivo liver unscheduled DNA-synthesis (UDS) assay. Unpublished report from Firmenich, Inc., August 9. Report number 37964. RIFM, Woodcliff Lake, NJ, USA.
202. RIFM (Research Institute for Fragrance Materials, Inc.), 2001c. Methyl dihydrojasmonate: L5178Y TK+/- mouse lymphoma forward mutation assay with a confirmatory assay. Unpublished report from Firmenich, Inc., February 27. Report number 37013. RIFM, Woodcliff Lake, NJ, USA.
203. RIFM (Research Institute for Fragrance Materials, Inc.), 2001d. Acute dermal irritation in rabbits. Unpublished report from Firmenich, Inc., September 21. Report number 38241. RIFM, Woodcliff Lake, NJ, USA.
204. RIFM (Research Institute for Fragrance Materials, Inc.), 2001e. Acute dermal irritation in rabbits. Unpublished report from Firmenich, Inc., September 27. Report number 43013. RIFM, Woodcliff Lake, NJ, USA.
205. RIFM (Research Institute for Fragrance Materials, Inc.), 2002. Cytotoxicity assay in vitro with BALB/C3T3 cells: neural red test with cis-jasmone. Unpublished report from Givaudon, October 21. Report number 57172. RIFM, Woodcliff Lake, NJ, USA.
206. RIFM (Research Institute for Fragrance Materials, Inc.), 2003a. Airborne levels of selected fragrance materials in a simulated bathroom. RIFM report number 41708, January 10. RIFM, Woodcliff Lake, NJ, USA.
207. RIFM (Research Institute for Fragrance Materials, Inc.), 2003b. Indoor air quality evaluation of a plug-in air freshener. RIFM report number 43292, October 20. RIFM, Woodcliff Lake, NJ, USA.
208. RIFM (Research Institute for Fragrance Materials, Inc.), 2003c. Salmonella typhimurium reverse mutation assay with jasmone cis. Unpublished report from Givaudan Vernier. January 15. Report number 42045. RIFM, Woodcliff Lake, NJ, USA.
209. RIFM (Research Institute for Fragrance Materials, Inc.), 2003d. Repeated insult patch study of methyl dihydrojasmonate at 20.0% in diethyl phthalate (DEP). Report number 43009. RIFM, Woodcliff Lake, NJ, USA.
210. RIFM (Research Institute for Fragrance Materials, Inc.), 2004a. Airborne levels of selected fragrance materials following a controlled exposure to a surrogate fine fragrance. RIFM report number 47425, December 3. RIFM, Woodcliff Lake, NJ, USA.
211. RIFM (Research Institute for Fragrance Materials, Inc.), 2004b. Isojasmone B 11: Reverse mutation assay "Ames test" using Salmonella typhimurim. Unpublished report from Givaudan Suisse SA, February 23. Report number 44279. RIFM, Woodcliff Lake, NJ, USA.
212. RIFM (Research Institute for Fragrance Materials, Inc.), 2004c. Murine local lymphnode assay. Unpublished report from Firmenich, Inc., February 10. Report number 44316. RIFM, Woodcliff Lake, NJ, USA.
213. RIFM (Research Institute for Fragrance Materials, Inc.), 2005a. Repeated insult patch study of 2-hexylidene cyclopentanone at 0.6% in 75% diethyl phthalage (DEP)/25% ethanol. Report number 48712. RIFM, Woodcliff Lake, NJ, USA.
214. RIFM (Research Institute for Fragrance Materials, Inc.), 2005b. Repeated insult patch study of methyl dihydrojasmonate at 20% in diethyl phthalate (DEP)/25% ethanol. Unpublished report from Firmenich, Inc., June 22. Report number 49735. RIFM, Woodcliff Lake, NJ, USA.
215. RIFM (Research Institute for Fragrance Materials, Inc.), 2006a. 2-Pentylcyclopentan-1-one (delphone): Reverse mutation assay Ames Test" using Salmonella typhimurium and Escherichia coli. Unpublished report from Firmenich, Inc., July 15. Report number 58638. RIFM, Woodcliff Lake, NJ, USA.
216. RIFM (Research Institute for Fragrance Materials, Inc.), 2006b. Micronucleus test in the mouse with 2-(p-menth-1-ene-10-yl)cyclopentanone (nectarly). Unpublished report from Givaudon, October 12. Report number 56773. RIFM, Woodcliff Lake, NJ, USA.
217. RIFM (Research Institute for Fragrance Materials, Inc.), 2007. Oral (gavage) developmental toxicity study of methyl dihydrojasmonate (MDJ) in rats. RIFM report number 52788, April 20. RIFM, Woodcliff Lake, NJ, USA.
218. RIFM (Research Institiute for Fragrance Materials, Inc.), 2008a. Evaluation of the mutagenic activity of methyl hexyl oxo cyclopentanone carboxylate (dihydro isojasmonate) in the Salmonella typhimurium reverse mutation assay (with independent repeat). Unpublished report from PFW Aroma Chemicals B.V., June 9. Report number 55156. RIFM, Woodcliff Lake, NJ, USA.
219. RIFM (Research Institiute for Fragrance Materials, Inc.), 2008b. Local Lymph Node Assay with 2-hexylidene cyclopentanone. Unpublished report from J.M.Chapdelaine, July 29. Report number 55548. RIFM, Woodcliff Lake, NJ, USA.
220. RIFM (Research Institiute for Fragrance Materials, Inc.), 2010a. Repeated insult patch test with 3-methyl-2-(pentyloxy)cyclopent-2-en-1-one. Report number 61791. RIFM, Woodcliff Lake, NJ, USA).
221. RIFM (Research Institiute for Fragrance Materials, Inc.), 2010b. Local Lymph Node Assay with 2-heptylidenecyclopentan-1-one. Report number 61792. RIFM, Woodcliff Lake, NJ, USA.
222. Rogers R.E., Isola D.A., Jeng C-J., Lefebvre A., Smith L.W. Simulated inhalation levels of fragrance materials in a surrogate air freshener formulation. Environmtal Science and Technology 2005, 39:7810-7816.
223. Rusch R.M., Rodwell D.E., Nemec M.D., Tasker E.J. A teratology screening study in rats with cyclopentanone. Toxicologist 1988, 8:213.
224. Sasaki Y.F., Imanishi H., Ohta T., Shirasu Y. Modifying effects of components of plant essence on the induction of sister-chromatid exchanges in cultured Chinese hamster ovary cells. Mutation Research 1989, 226:103-110.
225. Sharp D.W. The sensitization potential of some perfume ingredients tested using a modified Draize procedure. Toxicology 1978, 9(3):261-271.
226. Scognamiglio, J., Letizia, C.S., Api, A.M., in press-a. Fragrance material review on cyclopentanone. Food and Chemical Toxicology. http://dx.doi.org/10.1016/j.fct.2012.03.027.
227. Scognamiglio, J., Letizia, C.S., Api, A.M., in press-b. Fragrance material review on 2-cyclopentylcyclopentanone. Food and Chemical Toxicology. http://dx.doi.org/10.1016/j.fct.2012.03.017.
228. Scognamiglio, J., Letizia, C.S., Api, A.M., in press-c. Fragrance material review on cyclotene propionate. Food and Chemical Toxicology. http://dx.doi.org/10.1016/j.fct.2012.03.031.
229. Scognamiglio, J., Letizia, C.S., Api, A.M., in press-d. Fragrance material review on dihydroisojasmone. Food and Chemical Toxicology. http://dx.doi.org/10.1016/j.fct.2012.03.029.
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