메뉴 건너뛰기




Volumn 28, Issue 4, 2012, Pages 1139-1145

BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer

Author keywords

C X C chemokine receptor 4; Dietary supplement; Lung cancer metastasis; Triple negative breast cancer cells; Urokinase plasminogen activator

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; BREASTDEFEND; CHEMOKINE RECEPTOR CXCR4; UNCLASSIFIED DRUG; UROKINASE;

EID: 84866454139     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1936     Document Type: Article
Times cited : (25)

References (42)
  • 3
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • Aggarwal BB and Shishodia S: Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71: 1397-1421, 2006.
    • (2006) Biochem Pharmacol , vol.71 , pp. 1397-1421
    • Aggarwal, B.B.1    Shishodia, S.2
  • 4
    • 39149098498 scopus 로고    scopus 로고
    • Vitamin and mineral supplement use among US adults after cancer diagnosis: A systematic review
    • DOI 10.1200/JCO.2007.13.5905
    • Velicer CM and Ulrich CM: Vitamin and mineral supplement use among US adults after cancer diagnosis: a systematic review. J Clin Oncol 26: 665-673, 2008. (Pubitemid 351264364)
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.4 , pp. 665-673
    • Velicer, C.M.1    Ulrich, C.M.2
  • 6
    • 79959806096 scopus 로고    scopus 로고
    • Suppression of proliferation and invasive behavior of human metastatic breast cancer cells by dietary supplement BreastDefend
    • Jiang J, Wojnowski R, Jedinak A and Sliva D: Suppression of proliferation and invasive behavior of human metastatic breast cancer cells by dietary supplement BreastDefend. Integr Cancer Ther 10: 192-200, 2011.
    • (2011) Integr Cancer Ther , vol.10 , pp. 192-200
    • Jiang, J.1    Wojnowski, R.2    Jedinak, A.3    Sliva, D.4
  • 7
    • 25144523473 scopus 로고    scopus 로고
    • Differential anti-tumor activity of Coriolus versicolor (Yunzhi) extract through p53- and/or Bcl-2-dependent apoptotic pathway in human breast cancer cells
    • Ho CY, Kim CF, Leung KN, Fung KP, Tse TF, Chan H and Lau CB: Differential anti-tumor activity of Coriolus versicolor (Yunzhi) extract through p53- and/or Bcl-2-dependent apoptotic pathway in human breast cancer cells. Cancer Biol Ther 4: 638-644, 2005.
    • (2005) Cancer Biol Ther , vol.4 , pp. 638-644
    • Ho, C.Y.1    Kim, C.F.2    Leung, K.N.3    Fung, K.P.4    Tse, T.F.5    Chan, H.6    Lau, C.B.7
  • 8
    • 33749356826 scopus 로고    scopus 로고
    • Ganoderma lucidum inhibits proliferation of human breast cancer cells by downregulation of estrogen receptor and NF-kappaB signaling
    • Jiang J, Slivova V and Sliva D: Ganoderma lucidum inhibits proliferation of human breast cancer cells by downregulation of estrogen receptor and NF-kappaB signaling. Int J Oncol 29: 695-703, 2006.
    • (2006) Int J Oncol , vol.29 , pp. 695-703
    • Jiang, J.1    Slivova, V.2    Sliva, D.3
  • 9
    • 33846240738 scopus 로고    scopus 로고
    • Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion
    • Thyagarajan A, Jiang J, Hopf A, Adamec J and Sliva D: Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion. Int J Mol Med 18: 657-664, 2006.
    • (2006) Int J Mol Med , vol.18 , pp. 657-664
    • Thyagarajan, A.1    Jiang, J.2    Hopf, A.3    Adamec, J.4    Sliva, D.5
  • 10
    • 46749100200 scopus 로고    scopus 로고
    • Suppression of cancer invasiveness by dietary compounds
    • Sliva D: Suppression of cancer invasiveness by dietary compounds. Mini Rev Med Chem 8: 677-688, 2008.
    • (2008) Mini Rev Med Chem , vol.8 , pp. 677-688
    • Sliva, D.1
  • 11
    • 77955323884 scopus 로고    scopus 로고
    • Photo-activated pheophorbide-a, an active component of Scutellaria barbata, enhances apoptosis via the suppression of ERK-mediated autophagy in the estrogen receptor-negative human breast adenocarcinoma cells MDA-MB-231
    • Bui-Xuan NH, Tang PM, Wong CK and Fung KP: Photo-activated pheophorbide-a, an active component of Scutellaria barbata, enhances apoptosis via the suppression of ERK-mediated autophagy in the estrogen receptor-negative human breast adenocarcinoma cells MDA-MB-231. J Ethnopharmacol 131: 95-103, 2010.
    • (2010) J Ethnopharmacol , vol.131 , pp. 95-103
    • Bui-Xuan, N.H.1    Tang, P.M.2    Wong, C.K.3    Fung, K.P.4
  • 12
    • 42549160933 scopus 로고    scopus 로고
    • Effects of Astragalus injection on proliferation of basal-like breast cancer cell line MDA-MB-468
    • Ye MN and Chen HF: Effects of Astragalus injection on proliferation of basal-like breast cancer cell line MDA-MB-468. Zhong Xi Yi Jie He Xue Bao 6: 399-404, 2008.
    • (2008) Zhong Xi Yi Jie He Xue Bao , vol.6 , pp. 399-404
    • Ye, M.N.1    Chen, H.F.2
  • 17
    • 43449106769 scopus 로고    scopus 로고
    • CXCR4 and CXCL12 down-regulation: A novel mechanism for the chemoprotection of 3,3′-diindolylmethane for breast and ovarian cancers
    • Hsu EL, Chen N, Westbrook A, Wang F, Zhang R, Taylor RT and Hankinson O: CXCR4 and CXCL12 down-regulation: a novel mechanism for the chemoprotection of 3,3′-diindolylmethane for breast and ovarian cancers. Cancer Lett 265: 113-123, 2008.
    • (2008) Cancer Lett , vol.265 , pp. 113-123
    • Hsu, E.L.1    Chen, N.2    Westbrook, A.3    Wang, F.4    Zhang, R.5    Taylor, R.T.6    Hankinson, O.7
  • 18
    • 70350500114 scopus 로고    scopus 로고
    • Down-regulation of uPA and uPAR by 3,3′-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells
    • Ahmad A, Kong D, Wang Z, Sarkar SH, Banerjee S and Sarkar FH: Down-regulation of uPA and uPAR by 3,3′-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells. J Cell Biochem 108: 916-925, 2009.
    • (2009) J Cell Biochem , vol.108 , pp. 916-925
    • Ahmad, A.1    Kong, D.2    Wang, Z.3    Sarkar, S.H.4    Banerjee, S.5    Sarkar, F.H.6
  • 19
    • 30644462746 scopus 로고    scopus 로고
    • The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells
    • Elliott BE, Meens JA, SenGupta SK, Louvard D and Arpin M: The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells. Breast Cancer Res 7: R365-R373, 2005.
    • (2005) Breast Cancer Res , vol.7
    • Elliott, B.E.1    Meens, J.A.2    SenGupta, S.K.3    Louvard, D.4    Arpin, M.5
  • 20
    • 0026530145 scopus 로고
    • Invasive and metastatic properties of MCF-7 cells and rasH-transfected MCF-7 cell lines
    • Gelmann EP, Thompson EW and Sommers CL: Invasive and metastatic properties of MCF-7 cells and rasH-transfected MCF-7 cell lines. Int J Cancer 50: 665-669, 1992.
    • (1992) Int J Cancer , vol.50 , pp. 665-669
    • Gelmann, E.P.1    Thompson, E.W.2    Sommers, C.L.3
  • 21
    • 0038745381 scopus 로고    scopus 로고
    • The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis
    • Xue C, Plieth D, Venkov C, Xu C and Neilson EG: The gate-keeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis. Cancer Res 63: 3386-3394, 2003. (Pubitemid 36735899)
    • (2003) Cancer Research , vol.63 , Issue.12 , pp. 3386-3394
    • Xue, C.1    Plieth, D.2    Venkov, C.3    Xu, C.4    Neilson, E.G.5
  • 22
    • 22344439300 scopus 로고    scopus 로고
    • Estrogen or antiprogestin treatment induces complete regression of pulmonary and axillary metastases in an experimental model of breast cancer progression
    • DOI 10.1093/carcin/bgi060
    • Vanzulli SI, Soldati R, Meiss R, Colombo L, Molinolo AA and Lanari C: Estrogen or antiprogestin treatment induces complete regression of pulmonary and axillary metastases in an experimental model of breast cancer progression. Carcinogenesis 26: 1055-1063, 2005. (Pubitemid 41214298)
    • (2005) Carcinogenesis , vol.26 , Issue.6 , pp. 1055-1063
    • Vanzulli, S.I.1    Soldati, R.2    Meiss, R.3    Colombo, L.4    Molinolo, A.A.5    Lanari, C.6
  • 23
    • 33846226109 scopus 로고    scopus 로고
    • TIP30/CC3 expression in breast carcinoma: relation to metastasis, clinicopathologic parameters, and P53 expression
    • DOI 10.1016/j.humpath.2006.08.005, PII S0046817706004965
    • Zhao J, Ni H, Ma Y, Dong L, Dai J, Zhao F, Yan X, et al: TIP30/CC3 expression in breast carcinoma: relation to metastasis, clinicopathologic parameters, and P53 expression. Hum Pathol 38: 293-298, 2007. (Pubitemid 46096554)
    • (2007) Human Pathology , vol.38 , Issue.2 , pp. 293-298
    • Zhao, J.1    Ni, H.2    Ma, Y.3    Dong, L.4    Dai, J.5    Zhao, F.6    Yan, X.7    Lu, B.8    Xu, H.9    Guo, Y.10
  • 24
    • 27144468987 scopus 로고    scopus 로고
    • Curcumin suppresses the paclitaxel-induced nuclear factor-κB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice
    • DOI 10.1158/1078-0432.CCR-05-1192
    • Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, Bueso-Ramos CE and Price JE: Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res 11: 7490-7498, 2005. (Pubitemid 41507710)
    • (2005) Clinical Cancer Research , vol.11 , Issue.20 , pp. 7490-7498
    • Aggarwal, B.B.1    Shishodia, S.2    Takada, Y.3    Banerjee, S.4    Newman, R.A.5    Bueso-Ramos, C.E.6    Price, J.E.7
  • 25
    • 37349021728 scopus 로고    scopus 로고
    • Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells
    • Lee WJ, Chen WK, Wang CJ, Lin WL and Tseng TH: Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells. Toxicol Appl Pharmacol 226: 178-191, 2008.
    • (2008) Toxicol Appl Pharmacol , vol.226 , pp. 178-191
    • Lee, W.J.1    Chen, W.K.2    Wang, C.J.3    Lin, W.L.4    Tseng, T.H.5
  • 26
    • 0032411673 scopus 로고    scopus 로고
    • Contribution of cytokines on the suppression of lung metastasis
    • DOI 10.1023/A:1008070025561
    • Ishihara Y, Iijima H and Matsunaga K: Contribution of cytokines on the suppression of lung metastasis. Biotherapy 11: 267-275, 1998. (Pubitemid 29044694)
    • (1998) Biotherapy , vol.11 , Issue.4 , pp. 267-275
    • Ishihara, Y.1    Lijima, H.2    Matsunaga, K.3
  • 27
    • 84857795063 scopus 로고    scopus 로고
    • Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN(®) ): Review of development and future perspectives
    • Maehara Y, Tsujitani S, Saeki H, Oki E, Yoshinaga K, Emi Y, Morita M, et al: Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN(®) ): review of development and future perspectives. Surg Today 42: 8-28, 2012.
    • (2012) Surg Today , vol.42 , pp. 8-28
    • Maehara, Y.1    Tsujitani, S.2    Saeki, H.3    Oki, E.4    Yoshinaga, K.5    Emi, Y.6    Morita, M.7
  • 28
    • 0032984321 scopus 로고    scopus 로고
    • The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis
    • DOI 10.1016/S0162-3109(98)00063-0, PII S0162310998000630
    • Han SB, Lee CW, Jeon YJ, Hong ND, Yoo ID, Yang KH and Kim HM: The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis. Immunopharmacology 41: 157-164, 1999. (Pubitemid 29099828)
    • (1999) Immunopharmacology , vol.41 , Issue.2 , pp. 157-164
    • Han, S.B.1    Lee, C.W.2    Jeon, Y.J.3    Hong, N.D.4    Yoo, I.D.5    Yang, K.-H.6    Kim, H.M.7
  • 29
    • 18444391471 scopus 로고    scopus 로고
    • Cambodian Phellinus linteus inhibits experimental metastasis of melanoma cells in mice via regulation of urokinase type plasminogen activator
    • Lee HJ, Lee HJ, Lim ES, Ahn KS, Shim BS, Kim HM, Gong SJ, et al: Cambodian Phellinus linteus inhibits experimental metastasis of melanoma cells in mice via regulation of urokinase type plasminogen activator. Biol Pharm Bull 28: 27-31, 2005.
    • (2005) Biol Pharm Bull , vol.28 , pp. 27-31
    • Lee, H.J.1    Lee, H.J.2    Lim, E.S.3    Ahn, K.S.4    Shim, B.S.5    Kim, H.M.6    Gong, S.J.7
  • 30
    • 0036871314 scopus 로고    scopus 로고
    • Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: Mechanism of action and isolation of an active substance
    • Kimura Y, Taniguchi M and Baba K: Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance. Anticancer Res 22: 3309-3318, 2002. (Pubitemid 36070107)
    • (2002) Anticancer Research , vol.22 , Issue.6 A , pp. 3309-3318
    • Kimura, Y.1    Taniguchi, M.2    Baba, K.3
  • 31
    • 45849099048 scopus 로고    scopus 로고
    • Effects of the antlered form of Ganoderma lucidum on tumor growth and metastasis in cyclophosphamide-treated mice
    • DOI 10.1271/bbb.70607
    • Nonaka Y, Ishibashi H, Nakai M, Shibata H, Kiso Y and Abe S: Effects of the antlered form of Ganoderma lucidum on tumor growth and metastasis in cyclophosphamide-treated mice. Biosci Biotechnol Biochem 72: 1399-1408, 2008. (Pubitemid 351883775)
    • (2008) Bioscience, Biotechnology and Biochemistry , vol.72 , Issue.6 , pp. 1399-1408
    • Nonaka, Y.1    Ishibashi, H.2    Nakai, M.3    Shibata, H.4    Kiso, Y.5    Abe, S.6
  • 32
    • 77950818771 scopus 로고    scopus 로고
    • Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression
    • Chen NH, Liu JW and Zhong JJ: Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression. Pharmacol Rep 62: 150-163, 2010.
    • (2010) Pharmacol Rep , vol.62 , pp. 150-163
    • Chen, N.H.1    Liu, J.W.2    Zhong, J.J.3
  • 33
    • 72249116503 scopus 로고    scopus 로고
    • Oral administration of 3,3′-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice
    • Kim EJ, Shin M, Park H, Hong JE, Shin HK, Kim J, Kwon DY, et al: Oral administration of 3,3′-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice. J Nutr 139: 2373-2379, 2009.
    • (2009) J Nutr , vol.139 , pp. 2373-2379
    • Kim, E.J.1    Shin, M.2    Park, H.3    Hong, J.E.4    Shin, H.K.5    Kim, J.6    Kwon, D.Y.7
  • 34
    • 42149085554 scopus 로고    scopus 로고
    • Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling
    • DOI 10.1038/sj.bjc.6604319, PII 6604319
    • Sliva D, Jedinak A, Kawasaki J, Harvey K and Slivova V: Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling. Br J Cancer 98: 1348-1356, 2008. (Pubitemid 351543583)
    • (2008) British Journal of Cancer , vol.98 , Issue.8 , pp. 1348-1356
    • Sliva, D.1    Jedinak, A.2    Kawasaki, J.3    Harvey, K.4    Slivova, V.5
  • 35
    • 24644441893 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator system and breast cancer
    • (review)
    • Han B, Nakamura M, Mori I, Nakamura Y and Kakudo K: Urokinase-type plasminogen activator system and breast cancer (review). Oncol Rep 14: 105-112, 2005.
    • (2005) Oncol Rep , vol.14 , pp. 105-112
    • Han, B.1    Nakamura, M.2    Mori, I.3    Nakamura, Y.4    Kakudo, K.5
  • 36
    • 0035863308 scopus 로고    scopus 로고
    • Direct evidence of the importance of stromal urokinase plasminogen activator (uPA) in the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model
    • Frandsen TL, Holst-Hansen C, Nielsen BS, Christensen IJ, Nyengaard JR, Carmeliet P and Brünner N: Direct evidence of the importance of stromal urokinase plasminogen activator (uPA) in the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model. Cancer Res 61: 532-537, 2001. (Pubitemid 32128612)
    • (2001) Cancer Research , vol.61 , Issue.2 , pp. 532-537
    • Frandsen, T.L.1    Holst-Hansen, C.2    Nielsen, S.B.3    Christensen, I.J.4    Nyengaard, J.R.5    Carmeliet, P.6    Brunner, N.7
  • 39
    • 72449187631 scopus 로고    scopus 로고
    • Phenotypic knockout of CXCR4 by a novel recombinant protein TAT/54R/KDEL inhibits tumors metastasis
    • Ma WF, Du J, Fu LP, Fang R, Chen HY and Cai SH: Phenotypic knockout of CXCR4 by a novel recombinant protein TAT/54R/KDEL inhibits tumors metastasis. Mol Cancer Res 7: 1613-1621, 2009.
    • (2009) Mol Cancer Res , vol.7 , pp. 1613-1621
    • Ma, W.F.1    Du, J.2    Fu, L.P.3    Fang, R.4    Chen, H.Y.5    Cai, S.H.6
  • 40
    • 78751643333 scopus 로고    scopus 로고
    • Sustained inhibition of PKCα reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model
    • Kim J, Thorne SH, Sun L, Huang B and Mochly-Rosen D: Sustained inhibition of PKCα reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model. Oncogene 30: 323-333, 2011.
    • (2011) Oncogene , vol.30 , pp. 323-333
    • Kim, J.1    Thorne, S.H.2    Sun, L.3    Huang, B.4    Mochly-Rosen, D.5
  • 42
    • 33847136743 scopus 로고    scopus 로고
    • Triple-negative breast cancer: therapeutic options
    • DOI 10.1016/S1470-2045(07)70074-8, PII S1470204507700748
    • Cleator S, Heller W and Coombes RC: Triple-negative breast cancer: therapeutic options. Lancet Oncol 8: 235-244, 2007. (Pubitemid 46291713)
    • (2007) Lancet Oncology , vol.8 , Issue.3 , pp. 235-244
    • Cleator, S.1    Heller, W.2    Coombes, R.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.