VEA1 is required for cleistothecial formation and virulence in Histoplasma capsulatum

Fungal Genetics and Biology

Volumn 49, Issue 10, 2012, Pages 838-846

  Laskowski Peak, Meggan C ^a,b   Calvo, Ana M ^c   Rohrssen, Jennifer ^c   George Smulian, A ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c NORTHERN ILLINOIS UNIVERSITY   (United States)

Author keywords

Cleistothecia; Complementation; Histoplasma capsulatum; Mating; Sexual development; VeA; Virulence

Indexed keywords

FUNGAL PROTEIN; STERIGMATOCYSTIN; UNCLASSIFIED DRUG; VELVET A1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FRUITING BODY; FUNGAL DEVELOPMENT; FUNGAL GENE; FUNGAL STRAIN; FUNGAL VIRULENCE; FUNGUS GROWTH; HISTOPLASMA CAPSULATUM; MOUSE; MYCELIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; SEXUAL DEVELOPMENT; TOXIN SYNTHESIS; VELVET A1 GENE;

ANIMALS; ASPERGILLUS NIDULANS; CELL LINE; CELL SURVIVAL; FRUITING BODIES, FUNGAL; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENE SILENCING; GENETIC COMPLEMENTATION TEST; HISTOPLASMA; LUNG; MACROPHAGES; MICE; MICE, INBRED C57BL; MYCELIUM; RNA, FUNGAL; SPLEEN; STERIGMATOCYSTIN; VIRULENCE;

AJELLOMYCES CAPSULATUS; CLEISTOTHECIA; EMERICELLA NIDULANS; FUNGI; MUS;

EID: 84866450421     PISSN: 10871845     EISSN: 10960937     Source Type: Journal    
DOI: 10.1016/j.fgb.2012.07.001     Document Type: Article

References (36)

1. Amaike S., Keller N.P. Distinct roles for VeA and LaeA in development and pathogenesis of Aspergillus flavus. Eukaryot. Cell 2009, 8:1051-1060.
2. Bayram Ö.S., Krappmann M., Ni J., Bok K., Helmstaedt O., Valerius S., Braus-Stromeyer N., Kwon N.P., Keller J.Yu., Braus G.H. VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science 2008, 320:1504.
3. Bayram O.S., Bayram O., Valerius O., Park H.S., Irniger S., Gerke J., Ni M., Han K.H., Yu J.H., Braus G.H. LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity. PLoS Genet. 2010, 6:e1001226.
4. Bayram O., Braus G.H., Fischer R., Rodriguez-Romero J. Spotlight on Aspergillus nidulans photosensory systems. Fungal Genet. Biol. 2010, 47:900-908.
5. Bok J.W., Keller N.P. LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryot. Cell 2004, 3:527-535.
6. Calvo A.M. The VeA regulatory system and its role in morphological and chemical development in fungi. Fungal Genet. Biol. 2008, 45:1053-1061.
7. Calvo A.M., Bok J., Brooks W., Keller N.P. VeA Is required for toxin and sclerotial production in Aspergillus parasiticus. Appl. Environ. Microbiol. 2004, 70:4733-4739.
8. DeMonbreun W.A. The cultivation and cultural characteristics of Darling's Histoplasma capsulatum. Am. J. Trop. Med. 1934, s1-14:93-125.
9. Duran R.M., Cary J.W., Calvo A.M. Production of cyclopiazonic acid, aflatrem and aflatoxin by Aspergillus flavus is regulated by veA, a gene necessary for sclerotial formation. Appl. Microbiol. Biotechnol. 2007, 73:1158-1168.
10. Duran R.M., Cary J.W., Calvo A.M. The role of veA on Aspergillus flavus infection of peanuts, corn and cotton. Open Mycol. J. 2009, 3:27-36.
11. Hilty J., Smulian A.G., Newman S.L. Histoplasma capsulatum utilizes siderophores for intracellular iron acquisition in macrophages. Med. Mycol. 2011, 49:633-642.
12. Holbrook E.D., Edwards J.A., Youseff B.H., Rappleye C.A. Definition of the extracellular proteome of pathogenic-phase Histoplasma capsulatum. J. Proteome Res. 2011, 10:1929-1943.
13. Hwang L.H., Mayfield J.A., Rine J., Sil A. Histoplasma requires SID1, a member of an iron-regulated siderophore gene cluster, for host colonization. PLoS Pathog. 2008, 4:e1000044.
14. Kato N., Brooks W., Calvo A.M. The expression of sterigmatocystin and penicillin genes in Aspergillus nidulans is controlled by veA, a gene required for sexual development. Eukaryot. Cell 2003, 2:1178-1186.
15. Kauffman C.A. Histoplasmosis: a clinical and laboratory update. Clin. Microbiol. Rev. 2007, 20:115-132.
16. Kim H., Han K., Kim K., Han D., Jahnq K., Chae K. The veA gene activates sexual development in Aspergillus nidulans. Fungal Genet. Biol. 2002, 37:72-80.
17. Krappmann S., Bayram O., Braus G.H. Deletion and allelic exchange of the Aspergillus fumigatus veA locus via a novel recyclable marker module. Eukaryot. Cell 2005, 4:1298-1307.
18. Kwon-Chung K.J., Weeks R.J., Larsh H.W. Studies on emmonsiella capsulata (Histoplasma Capsulatum). II. Distribution of the two mating types in 13 endemic states of the United States. Am. J. Epidemiol. 1974, 99:44-49.
19. Kwon-Chung K.J., Bartlett M.S., Wheat L.J. Distribution of the two mating types among Histoplasma Capsulatum isolates obtained from an urban histoplasmosis outbreak. Sabouraudia 1984, 22:155-157.
20. Laskowski M.C., Smulian A.G. Insertional mutagenesis enables cleistothecial formation in a non-mating strain of Histoplasma capsulatum. BMC Microbiol. 2010, 16(10):49.
21. Li S., Myung K., Guse D., Donkin B., Proctor R.H., Grayburn W.S., Calvo A.M. FvVE1 regulates filamentous growth, the ratio of microconidia to macroconidia and cell wall formation in Fusarium verticillioides. Mol. Microbiol. 2006, 62:1418-1432.
22. Marion C.L., Rappleye C.A., Engle J.T., Goldman W.E. An alpha-(1,4)-amylase is essential for alpha-(1,3)-glucan production and virulence in Histoplasma capsulatum. Mol. Microbiol. 2006, 62:970-983.
23. Medoff G., Sacco M., Maresca B., Schlessinger D., Painter A., Kobayashi G.S., Carratu L. Irreversible block of the mycelial-to-yeast phase transition of Histoplasma Capsulatum. Science 1986, 231:476-479.
24. Miller B.L., Miller K.Y., Timberlake W.E. Direct and indirect gene replacements in Aspergillus nidulans. Mol. Cell. Biol. 1985, 5:1714-1721.
25. Myung K., Li S., Butchko R.A.E., Busman M., Proctor R.H., Abbas H.K., Calvo A.M. FvVE1 regulates biosynthesis of the mycotoxins fumonisins and fusarins in Fusarium verticillioides. J. Agric. Food Chem. 2009, 57:5089-5094.
26. Myung K., Zitomer N.C., Duvall M., Glenn A.E., Riley R.T., Calvo A.M. The conserved global regulator VeA is necessary for symptom production and mycotoxin synthesis in maize seedlings by Fusarium verticillioides. Plant Pathol. 2011, http://dx.doi.org/10.1111/j.1365-3059.2011.02504.
27. Nemecek J.C., Wuthrich M., Klein B.S. Global control of dimorphism and virulence in fungi. Science 2006, 312:583-588.
28. Nguyen V.Q., Sil A. Temperature-induced switch to the pathogenic yeast form of Histoplasma Capsulatum requires Ryp1, a conserved transcriptional regulator. Proc. Natl. Acad. Sci. USA 2008, 105:4880-4885.
29. Ni M., Yu J.H. A novel regulator couples sporogenesis and trehalose biogenesis in Aspergillus nidulans. PLoS One 2007, 2:e970.
30. Purschwitz J., Müller S., Kastner C., Schöser M., Haas H., Espeso E.A., Atoui A., Calvo A.M., Fischer R. Functional and physical interaction of blue- and red-light sensors in Aspergillus nidulans. Curr. Biol. 2008, 18:255-259.
31. Smulian A.G., Gibbons R.S., Demland J.A., Spaulding D.T., Deepe G.S. Expression of hygromycin phosphotransferase alters virulence of Histoplasma capsulatum. Eukaryot. Cell 2007, 6:2066-2071.
32. Stinnett S.M., Espeso E.A., Cobeño L., Araújo-Bazán L., Calvo A.M. Aspergillus nidulans VeA subcellular localization is dependent on the importin α carrier and on light. Mol. Microbiol. 2007, 63:242-255.
33. Strasser J.E., Newman S.L., Ciraolo G.M., Morris R.E., Howell M.L., Dean G.E. Regulation of the macrophage vacuolar ATPase and phagosome-lysosome fusion by Histoplasma capsulatum. J. Immunol. 1999, 162:6148-6154.
34. Webster R.H., Sil A. Conserved factors Ryp2 and Ryp3 control cell morphology and infectious spore formation in the fungal pathogen Histoplasma Capsulatum. Proc. Natl. Acad. Sci. USA 2008, 105:14573-14578.
35. Woods J.P., Heinecke E.L., Goldman W.E. Electrotransformation and expression of bacterial genes encoding hygromycin phosphotransferase and beta-galactosidase in the pathogenic fungus Histoplasma capsulatum. Infect Immun. 1998, 66:1697-1707.
36. Woods J.P., Retallack D.M., Heinecke E.L., Goldman W.E. Rare homologous gene targeting in Histoplasma capsulatum: disruption of the URA5Hc gene by allelic replacement. J. Bacteriol. 1998, 180:5135-5143.