Omega 3 fatty acid inhibition of inflammatory cytokine-mediated Connexin43 regulation in the heart

Frontiers in Physiology

Volumn 3 JUL, Issue , 2012, Pages

  Baum, Jennifer R ^a   Dolmatova, Elena ^a   Tan, Alex ^a   Duffy, Heather S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Arrhythmia; Fibrosis; Gap junction; Inflammation; Interleukin; Myocardial infarction

Indexed keywords

EID: 84866448680     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2012.00272     Document Type: Article

References (20)

1. Abbate, A., Van Tassell, B. W., Seropian, I. M., Toldo, S., Robati, R., Varma, A., Salloum, F. N., Smithson, L., and Dinarello, C. A. (2010). Interleukin-1beta modulation using a genetically engineered antibody prevents adverse cardiac remodelling following acute myocardial infarction in the mouse. Eur. J. Heart Fail. 12, 319-322.
2. Adkins, Y., and Kelley, D. S. (2010). Mechanisms underlying the car-dioprotective effects of omega-3 polyunsaturated fatty acids. J. Nutr. Biochem. 21, 781-792.
3. Alonso, F., Krattinger, N., Mazzolai, L., Simon, A., Waeber, G., Meda, P., and Haefliger, J. A. (2010). An angiotensin II-and NF-kappaB-dependent mechanism increases connexin 43 in murine arteries targeted by renin-dependent hypertension. Cardiovasc. Res. 87, 166-176.
4. Baum, J. R., Long, B., Cabo, C., and Duffy, H. S. (2012). Myofibroblasts cause heterogeneous Cx43 reduction and are unlikely to be coupled to myocytes in the healing canine infarct. Am. J. Physiol. Heart Circ. Physiol. 302, H790-H800.
5. Di Nunzio, M., Danesi, F., and Bordoni, A. (2009). n-3 PUFA as regulators of cardiac gene transcription: a new link between PPAR activation and fatty acid composition. Lipids 44, 1073-1079.
6. Duffy, H. S., John, G. R., Lee, S. C., Brosnan, C. F., and Spray, D. C. (2000). Reciprocal regulation of the junctional proteins claudin-1 and connexin43 by interleukin-1beta in primary human fetal astrocytes. J. Neurosci. 20, RC114.
7. Dyerberg, J., Bang, H. O., Stoffersen, E., Moncada, S., and Vane, J. R. (1978). Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet 2, 117-119.
8. Gutstein, D. E., Morley, G. E., Tamaddon, H., Vaidya, D., Schneider, M. D., Chen, J., Chien, K. R., Stuhlmann, H., and Fishman, G. I. (2001). Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inacti-vation of connexin43. Circ. Res. 88, 333-339.
9. Hallaq, H., Sellmayer, A., Smith, T. W., and Leaf, A. (1990). Protective effect of eicosapen-taenoic acid on ouabain toxicity in neonatal rat cardiac myocytes. Proc. Natl. Acad. Sci. U.S.A. 87, 7834-7838.
10. Kieken, F., Mutsaers, N., Dolmatova, E., Virgil, K., Wit, A. L., Kellezi, A., Hirst-Jensen, B. J., Duffy, H. S., and Sorgen, P. L. (2009). Structural and molecular mechanisms of gap junction remodeling in epicardial border zone myocytes following myocardial infarction. Circ. Res. 104, 1103-1112.
11. Kjolbye, A. L., Dikshteyn, M., Eloff, B. C., Deschenes, I., and Rosenbaum, D. S. (2008). Maintenance of intercellular coupling by the antiarrhythmic peptide rotigap-tide suppresses arrhythmogenic discordant alternans. Am. J. Physiol. Heart Circ. Physiol. 294, H41-H49.
12. Leaf, A., Xiao, Y. F., and Kang, J. X. (2002). Interactions of n-3 fatty acids with ion channels in excitable tissues. Prostaglandins Leukot. Essent. Fatty Acids 67, 113-120.
13. Levantesi, G., Silletta, M. G., and Marchioli, R. (2010). Uses and benefits of omega-3 ethyl esters in patients with cardiovascular disease. J. Multidiscip. Health 3, 79-96.
14. Macia, E., Dolmatova, E., Cabo, C., Sosinsky, A. Z., Dun, W., Coromilas, J., Ciaccio, E. J., Boyden, P. A., Wit, A. L., and Duffy, H. S. (2011). Characterization of gap junction remodeling in epicardial border zone of healing canine infarcts and electrophysiological effects of partial reversal by rotigaptide. Circ. Arrhythm. Electrophysiol. 4, 344-351.
15. Macleod, J. C., Macknight, A. D., and Rodrigo, G. C. (1998). The electrical and mechanical response of adult guinea pig and rat ventricular myocytes to omega3 polyunsat-urated fatty acids. Eur. J. Pharmacol. 356, 261-270.
16. Musa-Veloso, K., Binns, M. A., Kocenas, A., Chung, C., Rice, H., Oppedal-Olsen, H., Lloyd, H., and Lemke, S. (2011). Impact of low v. moderate intakes of long-chain n-3 fatty acids on risk of coronary heart disease. Br. J. Nutr. 106, 1129-1141.
17. Peters, N. S., Coromilas, J., Severs, N. J., and Wit, A. L. (1997). Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia. Circulation 95, 988-996.
18. Sohlenius, A. K., Reinfeldt, M., Backstrom, K., Bergstrand, A., and DePierre, J. W. (1996). Hepatic peroxisome proliferation in vitamin A-deficient mice without a simultaneous increase in peroxisomal acyl-CoA oxidase activity. Biochem. Pharmacol. 51, 821-827.
19. Wiegerinck, R. F., de Bakker, J. M., Opthof, T., de Jonge, N., Kirkels, H., Wilms-Schopman, F. J., and Coronel, R. (2009). The effect of enhanced gap junctional conductance on ventricular conduction in explanted hearts from patients with heart failure. Basic Res. Cardiol. 104, 321-332.
20. Yao, J. A., Hussain, W., Patel, P., Peters, N. S., Boyden, P. A., and Wit, A. L. (2003). Remodeling of gap junctional channel function in epicardial border zone of healing canine infarcts. Circ. Res. 92, 437-443.