Synthesis and Evaluation of a Selective Fluorogenic Pup Derived Assay Reagent for Dop, a Potential Drug Target in Mycobacterium tuberculosis

ChemBioChem

Volumn 13, Issue 14, 2012, Pages 2056-2060

  Merkx, Remco ^a   Burns, Kristin E ^b   Slobbe, Paul ^a   El Oualid, Farid ^a   El Atmioui, Dris ^a   Darwin, K Heran ^b   Ovaa, Huib ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Deamidase of Pup (Dop); Fluorescent probes; Protein protein interactions; Pup proteasome system (PPS); Tuberculosis

Indexed keywords

AMIDASE; BACTERIAL PROTEIN; DEAMIDASE OF PUP; PROKARYOTIC UBIQUITIN LIKE PROTEIN; PROTEASOME; PUP PROTEASOME SYSTEM; TUBERCULOSTATIC AGENT; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG TARGETING; ENZYME STRUCTURE; ENZYME SYNTHESIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

AMIDOHYDROLASES; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BIOCATALYSIS; ENZYME INHIBITORS; FLUORESCENT DYES; HIGH-THROUGHPUT SCREENING ASSAYS; HYDROLYSIS; KINETICS; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; PEPTIDES; SUBSTRATE SPECIFICITY; UBIQUITINS; VIRULENCE FACTORS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 84866448671     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201200460     Document Type: Article

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