Mycobacterial ubiquitin-like protein ligase PafA follows a two-step reaction pathway with a phosphorylated Pup intermediate

Journal of Biological Chemistry

Volumn 286, Issue 6, 2011, Pages 4412-4419

  Guth, Ethan ^a   Thommen, Michael ^a   Weber Ban, Eilika ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

FUNDAMENTAL FEATURES; LOW CONCENTRATIONS; LYSINE RESIDUES; M. TUBERCULOSIS; MYCOBACTERIAL; MYCOBACTERIUM TUBERCULOSIS; NOVEL TECHNIQUES; NUCLEOPHILIC ATTACK; ORDERS OF MAGNITUDE; OVERALL REACTIONS; PRODUCT FORMATION; PROTEASOMAL PATHWAY; PROTEIN SUBSTRATE; RATE LIMIT; RATE LIMITING; REACTION MECHANISM; SATURATING CONCENTRATION; SDS-PAGE ANALYSIS; STEADY STATE RATES; TARGET PROTEINS; TWO-STEP REACTION MECHANISMS; TWO-STEP REACTIONS; UBIQUITIN-LIKE PROTEINS;

ACTIVATION ANALYSIS; AMINO ACIDS; CARBOXYLATION; ENZYMES; PHOSPHORYLATION; REACTION INTERMEDIATES;

SUBSTRATES;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; GAMMA GLUTAMYL HYDROLASE; LYSINE; PROTEASOME; PUP PROTEIN; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE PAFA; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; PUP PROTEIN, MYCOBACTERIUM TUBERCULOSIS; UBIQUITIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONJUGATION; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; HYDROLYSIS; MICHAELIS CONSTANT; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOPHILICITY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; STEADY STATE; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

MYCOBACTERIUM TUBERCULOSIS;

ADENOSINE DIPHOSPHATE; BACTERIAL PROTEINS; CATALYSIS; MYCOBACTERIUM TUBERCULOSIS; PHOSPHORYLATION; UBIQUITIN-PROTEIN LIGASES; UBIQUITINS;

EID: 79953005868     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.189282     Document Type: Article

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