Urinary markers of renal inflammation in adolescents with Type1 diabetes mellitus and normoalbuminuria

Diabetic Medicine

Volumn 29, Issue 10, 2012, Pages 1297-1302

  Cherney, D Z I ^a   Scholey, J W ^a   Daneman, D ^b   Dunger, D B ^c   Dalton, R N ^d   Moineddin, R ^a   Mahmud, F H ^b   Dekker, R ^b   Elia, Y ^b   Sochett, E ^b   Reich, H N ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ALPHA2 INTERFERON; CHEMOKINE; CREATININE; CYTOKINE; EOTAXIN; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; FRACTALKINE; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; PLATELET DERIVED GROWTH FACTOR AA; RANTES; TRANSFORMING GROWTH FACTOR ALPHA;

ADOLESCENT; ADOLESCENT DISEASE; ALBUMINURIA; ARTICLE; DISEASE DURATION; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; NEPHRITIS; URINARY EXCRETION;

ADOLESCENT; ALBUMINURIA; BIOLOGICAL MARKERS; CHEMOKINES; CHILD; CREATINE; CYTOKINES; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; DISEASE PROGRESSION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFLAMMATION; MALE; RISK FACTORS;

EID: 84866445076     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2012.03651.x     Document Type: Article

References (23)

1. Dunger DB, Schwarze CP, Cooper JD, Widmer B, Neil HA, Shield J et al. Can we identify adolescents at high risk for nephropathy before the development of microalbuminuria? Diabet Med 2007; 24: 131-136.
2. Schultz CJ, Neil HA, Dalton RN, Dunger DB. Risk of nephropathy can be detected before the onset of microalbuminuria during the early years after diagnosis of type1 diabetes. Diabetes Care 2000; 23: 1811-1815.
3. von Eynatten M, Baumann M, Heemann U, Zdunek D, Hess G, Nawroth PP et al. Urinary L-FABP and anaemia: distinct roles of urinary markers in type2 diabetes. Eur J Clin Invest 2010; 40: 95-102.
4. Torres DD, Rossini M, Manno C, Mattace-Raso F, D'Altri C, Ranieri E et al. The ratio of epidermal growth factor to monocyte chemotactic peptide-1 in the urine predicts renal prognosis in IgA nephropathy. Kidney Int 2008; 73: 327-333.
5. Cherney DZ, Konvalinka A, Zinman B, Diamandis EP, Soosaipillai A, Reich H et al. Effect of protein kinase Cβ inhibition on renal hemodynamic function and urinary biomarkers in humans with type1 diabetes: a pilot study. Diabetes Care 2009; 32: 91-93.
6. Malek AM, Gibbons GH, Dzau VJ, Izumo S. Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium. J Clin Invest 1993; 92: 2013-2021.
7. Riser BL, Cortes P, Heilig C, Grondin J, Ladson-Wofford S, Patterson D et al. Cyclic stretching force selectively up-regulates transforming growth factor-β isoforms in cultured rat mesangial cells. Am J Pathol 1996; 148: 1915-1923.
8. Cooper ME. Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy. Diabetologia 2001; 44: 1957-1972.
9. Hostetter TH, Olson JL, Rennke HG, Venkatachalam MA, Brenner BM. Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation. Am J Physiol 1981; 241: F85-F93.
10. Adolescent type 1 Diabetes Cardio-renal Intervention Trial Group. Adolescent type1 Diabetes Cardio-renal Intervention Trial (AdDIT). BMC Pediatr 2009; 9: 79.
11. Kelly DJ, Zhang Y, Gow RM, Itescu S, Gilbert RE. Cells expressing the stem cell factor receptor, c-kit, contribute to neoangiogenesis in diabetes. Diab Vasc Dis Res 2005; 2: 76-80.
12. Niewczas MA, Ficociello LH, Johnson AC, Walker W, Rosolowsky ET, Roshan B et al. Serum concentrations of markers of TNFα and Fas-mediated pathways and renal function in non-proteinuric patients with type1 diabetes. Clin J Am Soc Nephrol 2009; 4: 62-70.
13. Ohshiro Y, Ma RC, Yasuda Y, Hiraoka-Yamamoto J, Clermont AC, Isshiki K et al. Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cβ-null mice. Diabetes 2006; 55: 3112-3120.
14. Ruster C, Wolf G. The role of chemokines and chemokine receptors in diabetic nephropathy. Front Biosci 2008; 13: 944-955.
15. Mezzano S, Aros C, Droguett A, Burgos ME, Ardiles L, Flores C et al. NF-κB activation and overexpression of regulated genes in human diabetic nephropathy. Nephrol Dial Transplant 2004; 19: 2505-2512.
16. Cherney DZ, Scholey JW, Sochett E, Bradley TJ, Reich HN. The acute effect of clamped hyperglycemia on the urinary excretion of inflammatory cytokines/chemokines in uncomplicated type1 DM: a pilot study. Diabetes Care 2011; 34: 177-180.
17. Schultz CJ, Konopelska-Bahu T, Dalton RN, Carroll TA, Stratton I, Gale EA et al. Microalbuminuria prevalence varies with age, sex, and puberty in children with type1 diabetes followed from diagnosis in a longitudinal study. Oxford Regional Prospective Study Group. Diabetes Care 1999; 22: 495-502.
18. Schwartz GJ, Munoz A, Schneider MF, Mak RH, Kaskel F, Warady BA et al. New equations to estimate GFR in children with CKD. J Am Soc Nephrol 2009; 20: 629-637.
19. Schwartz GJ, Work DF. Measurement and estimation of GFR in children and adolescents. Clin J Am Soc Nephrol 2009; 4: 1832-1843.
20. Wu CC, Chen JS, Lu KC, Chen CC, Lin SH, Chu P et al. Aberrant cytokines/chemokines production correlate with proteinuria in patients with overt diabetic nephropathy. Clin Chim Acta 2010; 411: 700-704.
21. Nomura S, Shouzu A, Omoto S, Nishikawa M, Iwasaka T. Effects of losartan and simvastatin on monocyte-derived microparticles in hypertensive patients with and without type2 diabetes mellitus. Clin Appl Thromb Hemost 2004; 10: 133-141.
22. Wolkow PP, Niewczas MA, Perkins B, Ficociello LH, Lipinski B, Warram JH et al. Association of urinary inflammatory markers and renal decline in microalbuminuric type1 diabetics. J Am Soc Nephrol 2008; 19: 789-797.
23. Yokota T, Ma RC, Park JY, Isshiki K, Sotiropoulos KB, Rauniyar RK et al. Role of protein kinaseC on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes 2003; 52: 838-845.