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Volumn 20, Issue 19, 2012, Pages 5992-6002

Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain

(7) Akdemir, Atilla a Edink, Ewald b Thompson, Andrew J c Lummis, Sarah C R c Kooistra, Albert J b De Graaf, Chris b De Esch, Iwan J P b

a BEZMIALEM VAKIF UNIVERSITY (Turkey)

b AMSTERDAM INSTITUTE FOR MOLECULES (Netherlands)

c UNIVERSITY OF CAMBRIDGE (United Kingdom)

Author keywords

7 Receptor; AChBP; Cys loop; Docking; In silico screening; nAChR; Virtual screening

Indexed keywords

BUNGAROTOXIN RECEPTOR; BUNGAROTOXIN RECEPTOR LIGAND; EPIBATIDINE; NICOTINIC AGENT; TRITIUM; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CHEMICAL STRUCTURE; CHIMERA; COMPUTER MODEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; INTERMETHOD COMPARISON; LIGAND BINDING; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; HEK293 CELLS; HUMANS; LIGANDS; MODELS, MOLECULAR; NICOTINIC ANTAGONISTS; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, NICOTINIC; SMALL MOLECULE LIBRARIES;

EID: 84866434365 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.06.054 Document Type: Article

Times cited : (11)

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