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Volumn 7, Issue 9, 2012, Pages

A Cell Culture Adapted HCV JFH1 Variant That Increases Viral Titers and Permits the Production of High Titer Infectious Chimeric Reporter Viruses

Author keywords

[No Author keywords available]

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; LUCIFERASE; NONSTRUCTURAL PROTEIN 5A; PROTEIN P58; VIRUS RNA;

EID: 84866432403     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044965     Document Type: Article
Times cited : (29)

References (62)
  • 1
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, et al. (1989) Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244: 359-362.
    • (1989) Science , vol.244 , pp. 359-362
    • Choo, Q.L.1    Kuo, G.2    Weiner, A.J.3    Overby, L.R.4    Bradley, D.W.5
  • 3
    • 0033992516 scopus 로고    scopus 로고
    • Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties
    • Reed KE, Rice C, (2000) Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties. Curr Top Microbiol Immunol 242: 55-84.
    • (2000) Curr Top Microbiol Immunol , vol.242 , pp. 55-84
    • Reed, K.E.1    Rice, C.2
  • 5
    • 80053264773 scopus 로고    scopus 로고
    • Turning Hepatitis C Virus into a Real Virus
    • Murray CL, Rice CM, (2011) Turning Hepatitis C Virus into a Real Virus. Annu Rev Microbiol 65: 307-27.
    • (2011) Annu Rev Microbiol , vol.65 , pp. 307-327
    • Murray, C.L.1    Rice, C.M.2
  • 6
    • 0036829816 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis C
    • Seeff LB, (2002) Natural history of chronic hepatitis C. Hepatology. 36: S35-S46.
    • (2002) Hepatology , vol.36
    • Seeff, L.B.1
  • 7
    • 0025166005 scopus 로고
    • Hepatitis C virus infection is associated with the development of hepatocellular carcinoma
    • Saito I, Miyamura T, Ohbayashi A, Harada H, Katayama T, et al. (1990) Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc Natl Acad Sci U S A 87: 6547-6549.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 6547-6549
    • Saito, I.1    Miyamura, T.2    Ohbayashi, A.3    Harada, H.4    Katayama, T.5
  • 11
    • 34447296186 scopus 로고    scopus 로고
    • Hepatitis C virus molecular clones and their replication capacity in vivo and in cell culture
    • Bartenschlager R, Sparacio S, (2007) Hepatitis C virus molecular clones and their replication capacity in vivo and in cell culture. Virus Res 127: 195-207.
    • (2007) Virus Res , vol.127 , pp. 195-207
    • Bartenschlager, R.1    Sparacio, S.2
  • 12
    • 0345188811 scopus 로고    scopus 로고
    • Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
    • Lohmann V, Korner F, Koch J, Herian U, Theilmann L, et al. (1999) Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 285: 110-113.
    • (1999) Science , vol.285 , pp. 110-113
    • Lohmann, V.1    Korner, F.2    Koch, J.3    Herian, U.4    Theilmann, L.5
  • 13
    • 0034623816 scopus 로고    scopus 로고
    • Efficient initiation of HCV RNA replication in cell culture
    • Blight KJ, Kolykhalov AA, Rice CM, (2000) Efficient initiation of HCV RNA replication in cell culture. Science 290: 1972-1974.
    • (2000) Science , vol.290 , pp. 1972-1974
    • Blight, K.J.1    Kolykhalov, A.A.2    Rice, C.M.3
  • 14
    • 22544470874 scopus 로고    scopus 로고
    • Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
    • Wakita T, Pietschmann T, Kato T, Date T, Miyamoto M, et al. (2005) Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med 11: 791-796.
    • (2005) Nat Med , vol.11 , pp. 791-796
    • Wakita, T.1    Pietschmann, T.2    Kato, T.3    Date, T.4    Miyamoto, M.5
  • 17
    • 36348950345 scopus 로고    scopus 로고
    • Cell culture adaptation of hepatitis C virus and in vivo viability of an adapted variant
    • Kaul A, Woerz I, Meuleman P, Leroux-Roels G, Bartenschlager R, (2007) Cell culture adaptation of hepatitis C virus and in vivo viability of an adapted variant. J Virol 81: 13168-13179.
    • (2007) J Virol , vol.81 , pp. 13168-13179
    • Kaul, A.1    Woerz, I.2    Meuleman, P.3    Leroux-Roels, G.4    Bartenschlager, R.5
  • 18
    • 33750740163 scopus 로고    scopus 로고
    • Persistent hepatitis C virus infection in vitro: coevolution of virus and host
    • Zhong J, Gastaminza P, Chung J, Stamataki Z, Isogawa M, et al. (2006) Persistent hepatitis C virus infection in vitro: coevolution of virus and host. J Virol 80: 11082-11093.
    • (2006) J Virol , vol.80 , pp. 11082-11093
    • Zhong, J.1    Gastaminza, P.2    Chung, J.3    Stamataki, Z.4    Isogawa, M.5
  • 19
    • 34548228594 scopus 로고    scopus 로고
    • Robust production of infectious viral particles in Huh-7 cells by introducing mutations in hepatitis C virus structural proteins
    • Delgrange D, Pillez A, Castelain S, Cocquerel L, Rouille Y, et al. (2007) Robust production of infectious viral particles in Huh-7 cells by introducing mutations in hepatitis C virus structural proteins. J Gen Virol 88: 2495-2503.
    • (2007) J Gen Virol , vol.88 , pp. 2495-2503
    • Delgrange, D.1    Pillez, A.2    Castelain, S.3    Cocquerel, L.4    Rouille, Y.5
  • 20
    • 41949086805 scopus 로고    scopus 로고
    • Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus
    • Russell RS, Meunier JC, Takikawa S, Faulk K, Engle RE, et al. (2008) Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus. Proc Natl Acad Sci U S A 105: 4370-4375.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 4370-4375
    • Russell, R.S.1    Meunier, J.C.2    Takikawa, S.3    Faulk, K.4    Engle, R.E.5
  • 21
    • 35648963197 scopus 로고    scopus 로고
    • Robust hepatitis C genotype 3a cell culture releasing adapted intergenotypic 3a/2a (S52/JFH1) viruses
    • Gottwein JM, Scheel TK, Hoegh AM, Lademann JB, Eugen-Olsen J, et al. (2007) Robust hepatitis C genotype 3a cell culture releasing adapted intergenotypic 3a/2a (S52/JFH1) viruses. Gastroenterology 133: 1614-1626.
    • (2007) Gastroenterology , vol.133 , pp. 1614-1626
    • Gottwein, J.M.1    Scheel, T.K.2    Hoegh, A.M.3    Lademann, J.B.4    Eugen-Olsen, J.5
  • 22
    • 33846111662 scopus 로고    scopus 로고
    • Compensatory mutations in E1, p7, NS2, and NS3 enhance yields of cell culture-infectious intergenotypic chimeric hepatitis C virus
    • Yi M, Ma Y, Yates J, Lemon SM, (2007) Compensatory mutations in E1, p7, NS2, and NS3 enhance yields of cell culture-infectious intergenotypic chimeric hepatitis C virus. J Virol 81: 629-638.
    • (2007) J Virol , vol.81 , pp. 629-638
    • Yi, M.1    Ma, Y.2    Yates, J.3    Lemon, S.M.4
  • 23
    • 67849133617 scopus 로고    scopus 로고
    • Efficient production of infectious hepatitis C virus with adaptive mutations in cultured hepatoma cells
    • Bungyoku Y, Shoji I, Makine T, Adachi T, Hayashida K, et al. (2009) Efficient production of infectious hepatitis C virus with adaptive mutations in cultured hepatoma cells. Journal of General Virology 90: 1681-1691.
    • (2009) Journal of General Virology , vol.90 , pp. 1681-1691
    • Bungyoku, Y.1    Shoji, I.2    Makine, T.3    Adachi, T.4    Hayashida, K.5
  • 24
    • 34547734952 scopus 로고    scopus 로고
    • Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus
    • Jones CT, Murray CL, Eastman DK, Tassello J, Rice CM, (2007) Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus. J Virol 81: 8374-8383.
    • (2007) J Virol , vol.81 , pp. 8374-8383
    • Jones, C.T.1    Murray, C.L.2    Eastman, D.K.3    Tassello, J.4    Rice, C.M.5
  • 25
    • 34547616693 scopus 로고    scopus 로고
    • Hepatitis C Virus p7 Protein Is Crucial for Assembly and Release of Infectious Virions
    • Steinmann E, Penin F, Kallis S, Patel AH, Bartenschlager R, et al. (2007) Hepatitis C Virus p7 Protein Is Crucial for Assembly and Release of Infectious Virions. PLoS Pathogens 3: e103.
    • (2007) PLoS Pathogens , vol.3
    • Steinmann, E.1    Penin, F.2    Kallis, S.3    Patel, A.H.4    Bartenschlager, R.5
  • 26
    • 69249231061 scopus 로고    scopus 로고
    • Hepatitis C virus NS2 protein contributes to virus particle assembly via opposing epistatic interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes
    • Phan T, Beran RK, Peters C, Lorenz IC, Lindenbach BD, (2009) Hepatitis C virus NS2 protein contributes to virus particle assembly via opposing epistatic interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes. J Virol 83: 8379-95.
    • (2009) J Virol , vol.83 , pp. 8379-8395
    • Phan, T.1    Beran, R.K.2    Peters, C.3    Lorenz, I.C.4    Lindenbach, B.D.5
  • 27
    • 0037040923 scopus 로고    scopus 로고
    • An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A
    • Brass V, Bieck E, Montserret R, Wolk B, Hellings JA, et al. (2002) An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A. J Biol Chem 277: 8130-8139.
    • (2002) J Biol Chem , vol.277 , pp. 8130-8139
    • Brass, V.1    Bieck, E.2    Montserret, R.3    Wolk, B.4    Hellings, J.A.5
  • 29
    • 19644393931 scopus 로고    scopus 로고
    • Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
    • Tellinghuisen TL, Marcotrigiano J, Rice CM, (2005) Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase. Nature 435: 374-379.
    • (2005) Nature , vol.435 , pp. 374-379
    • Tellinghuisen, T.L.1    Marcotrigiano, J.2    Rice, C.M.3
  • 30
    • 42949130180 scopus 로고    scopus 로고
    • Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly
    • Appel N, Zayas M, Miller S, Krijnse-Locker J, Schaller T, et al. (2008) Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly. PLoS Pathog 4: e1000035.
    • (2008) PLoS Pathog , vol.4
    • Appel, N.1    Zayas, M.2    Miller, S.3    Krijnse-Locker, J.4    Schaller, T.5
  • 31
    • 49149113893 scopus 로고    scopus 로고
    • Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles
    • Masaki T, Suzuki R, Murakami K, Aizaki H, Ishii K, et al. (2008) Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles. J Virol 82: 7964-7976.
    • (2008) J Virol , vol.82 , pp. 7964-7976
    • Masaki, T.1    Suzuki, R.2    Murakami, K.3    Aizaki, H.4    Ishii, K.5
  • 32
    • 38349162328 scopus 로고    scopus 로고
    • Identification of residues required for RNA replication in domains II and III of the hepatitis C virus NS5A protein
    • Tellinghuisen TL, Foss KL, Treadaway JC, Rice CM, (2008) Identification of residues required for RNA replication in domains II and III of the hepatitis C virus NS5A protein. J Virol 82: 1073-1083.
    • (2008) J Virol , vol.82 , pp. 1073-1083
    • Tellinghuisen, T.L.1    Foss, K.L.2    Treadaway, J.C.3    Rice, C.M.4
  • 33
    • 42949145532 scopus 로고    scopus 로고
    • Regulation of hepatitis C virion production via phosphorylation of the NS5A protein
    • Tellinghuisen TL, Foss KL, Treadaway J, (2008) Regulation of hepatitis C virion production via phosphorylation of the NS5A protein. PLoS Pathog 4: e1000032.
    • (2008) PLoS Pathog , vol.4
    • Tellinghuisen, T.L.1    Foss, K.L.2    Treadaway, J.3
  • 34
    • 34548188701 scopus 로고    scopus 로고
    • The C terminus of hepatitis C virus NS4A encodes an electrostatic switch that regulates NS5A hyperphosphorylation and viral replication
    • Lindenbach BD, Prágai BM, Montserret R, Beran RK, Pyle AM, et al. (2007) The C terminus of hepatitis C virus NS4A encodes an electrostatic switch that regulates NS5A hyperphosphorylation and viral replication. J Virol 81: 8905-8918.
    • (2007) J Virol , vol.81 , pp. 8905-8918
    • Lindenbach, B.D.1    Prágai, B.M.2    Montserret, R.3    Beran, R.K.4    Pyle, A.M.5
  • 35
    • 70349728564 scopus 로고    scopus 로고
    • A conserved proline between domains II and III of hepatitis C virus NS5A influences both RNA replication and virus assembly
    • Hughes M, Gretton S, Shelton H, Brown DD, McCormick CJ, et al. (2009) A conserved proline between domains II and III of hepatitis C virus NS5A influences both RNA replication and virus assembly. Virol 83: 10788-10796.
    • (2009) Virol , vol.83 , pp. 10788-10796
    • Hughes, M.1    Gretton, S.2    Shelton, H.3    Brown, D.D.4    McCormick, C.J.5
  • 36
    • 80052066409 scopus 로고    scopus 로고
    • Regulation of the Production of Infectious Genotype 1a Hepatitis C Virus by NS5A Domain III
    • Kim S, Welsch C, Yi M, Lemon SM, (2011) Regulation of the Production of Infectious Genotype 1a Hepatitis C Virus by NS5A Domain III. J Virol 85: 6645-6656.
    • (2011) J Virol , vol.85 , pp. 6645-6656
    • Kim, S.1    Welsch, C.2    Yi, M.3    Lemon, S.M.4
  • 37
    • 69449083296 scopus 로고    scopus 로고
    • Compensatory mutations in NS3 and NS5A proteins enhance the virus production capability of hepatitis C reporter virus
    • Han Q, Xu C, Wu C, Zhu W, Yang R, et al. (2009) Compensatory mutations in NS3 and NS5A proteins enhance the virus production capability of hepatitis C reporter virus. Virus Research 145: 63-73.
    • (2009) Virus Research , vol.145 , pp. 63-73
    • Han, Q.1    Xu, C.2    Wu, C.3    Zhu, W.4    Yang, R.5
  • 38
    • 0036893332 scopus 로고    scopus 로고
    • Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication
    • Blight KJ, McKeating JA, Rice CM, (2002) Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication. J Virol 76: 13001-13014.
    • (2002) J Virol , vol.76 , pp. 13001-13014
    • Blight, K.J.1    McKeating, J.A.2    Rice, C.M.3
  • 39
    • 0034972539 scopus 로고    scopus 로고
    • Sequence analysis of hepatitis C virus isolated from a fulminant hepatitis patient
    • Kato T, Furusaka A, Miyamoto M, Date T, Yasui K, et al. (2001) Sequence analysis of hepatitis C virus isolated from a fulminant hepatitis patient. J Med Virol 64: 334-339.
    • (2001) J Med Virol , vol.64 , pp. 334-339
    • Kato, T.1    Furusaka, A.2    Miyamoto, M.3    Date, T.4    Yasui, K.5
  • 40
    • 79951931345 scopus 로고    scopus 로고
    • ENCODE tiling array analysis identifies differentially expressed annotated and novel 5′ capped RNAs in hepatitis C infected liver
    • Folkers ME, Delker DA, Maxwell CI, Nelson CA, Schwartz JJ, et al. (2011) ENCODE tiling array analysis identifies differentially expressed annotated and novel 5′ capped RNAs in hepatitis C infected liver. PLoS One 6: e14697.
    • (2011) PLoS One , vol.6
    • Folkers, M.E.1    Delker, D.A.2    Maxwell, C.I.3    Nelson, C.A.4    Schwartz, J.J.5
  • 41
    • 0035032237 scopus 로고    scopus 로고
    • Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations
    • Krieger N, Lohmann V, Bartenschlager R, (2001) Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations. J Virol 75: 4614-4624.
    • (2001) J Virol , vol.75 , pp. 4614-4624
    • Krieger, N.1    Lohmann, V.2    Bartenschlager, R.3
  • 42
    • 78650917501 scopus 로고    scopus 로고
    • Measuring antiviral activity of benzimidazole molecules that alter IRES RNA structure with an infectious hepatitis C virus chimera expressing Renilla luciferase
    • Liu S, Nelson CA, Xiao L, Lu L, Seth PP, et al. (2011) Measuring antiviral activity of benzimidazole molecules that alter IRES RNA structure with an infectious hepatitis C virus chimera expressing Renilla luciferase. Antiviral Res 89: 54-63.
    • (2011) Antiviral Res , vol.89 , pp. 54-63
    • Liu, S.1    Nelson, C.A.2    Xiao, L.3    Lu, L.4    Seth, P.P.5
  • 43
    • 0018351318 scopus 로고
    • Propagation of human hepatitis A virus in cell culture in vitro
    • Provost PJ, Hilleman MR, (1979) Propagation of human hepatitis A virus in cell culture in vitro. Proc Soc Exp Biol Med 160: 213-221.
    • (1979) Proc Soc Exp Biol Med , vol.160 , pp. 213-221
    • Provost, P.J.1    Hilleman, M.R.2
  • 44
    • 0019461029 scopus 로고
    • Propagation of human hepatitis A virus in African green monkey kidney cell culture: primary isolation and serial passage
    • Daemer RJ, Feinstone SM, Gust ID, Purcell RH, (1981) Propagation of human hepatitis A virus in African green monkey kidney cell culture: primary isolation and serial passage. Infect Immun 32: 388-393.
    • (1981) Infect Immun , vol.32 , pp. 388-393
    • Daemer, R.J.1    Feinstone, S.M.2    Gust, I.D.3    Purcell, R.H.4
  • 45
    • 0021176152 scopus 로고
    • Primary isolation and serial passage of hepatitis A virus strains in primate cell cultures
    • Binn LN, Lemon SM, Marchwicki RH, Redfield RR, Gates NL, et al. (1984) Primary isolation and serial passage of hepatitis A virus strains in primate cell cultures. J Clin Microbiol 20: 28-33.
    • (1984) J Clin Microbiol , vol.20 , pp. 28-33
    • Binn, L.N.1    Lemon, S.M.2    Marchwicki, R.H.3    Redfield, R.R.4    Gates, N.L.5
  • 46
    • 0025656594 scopus 로고
    • Inactivated candidate vaccines for hepatitis A
    • Andre FE, Hepburn A, D'Hondt E, (1990) Inactivated candidate vaccines for hepatitis A. Prog Med Virol. 37: 72-95.
    • (1990) Prog Med Virol , vol.37 , pp. 72-95
    • Andre, F.E.1    Hepburn, A.2    D'Hondt, E.3
  • 47
    • 0026643021 scopus 로고
    • A controlled trial of a formalin-inactivated hepatitis A vaccine in healthy children
    • Werzberger A, Mensch B, Kuter B, Brown L, Lewis J, et al. (1992) A controlled trial of a formalin-inactivated hepatitis A vaccine in healthy children. N Engl J Med 327: 453-457.
    • (1992) N Engl J Med , vol.327 , pp. 453-457
    • Werzberger, A.1    Mensch, B.2    Kuter, B.3    Brown, L.4    Lewis, J.5
  • 48
    • 61949320778 scopus 로고    scopus 로고
    • Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs
    • Gottwein JM, Scheel TK, Jensen TB, Lademann JB, Prentoe JC, et al. (2009) Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs. Hepatology 49: 364-377.
    • (2009) Hepatology , vol.49 , pp. 364-377
    • Gottwein, J.M.1    Scheel, T.K.2    Jensen, T.B.3    Lademann, J.B.4    Prentoe, J.C.5
  • 49
    • 44649122005 scopus 로고    scopus 로고
    • Intragenotypic JFH1 based recombinant hepatitis C virus produces high levels of infectious particles but causes increased cell death
    • Mateu G, Donis RO, Wakita T, Bukh J, Grakoui A, (2008) Intragenotypic JFH1 based recombinant hepatitis C virus produces high levels of infectious particles but causes increased cell death. Virology 376: 397-407.
    • (2008) Virology , vol.376 , pp. 397-407
    • Mateu, G.1    Donis, R.O.2    Wakita, T.3    Bukh, J.4    Grakoui, A.5
  • 50
    • 78149434641 scopus 로고    scopus 로고
    • DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A
    • Coelmont L, Hanoulle X, Chatterji U, Berger C, Snoeck J, et al. (2010) DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A. PLoS One 5: e13687.
    • (2010) PLoS One , vol.5
    • Coelmont, L.1    Hanoulle, X.2    Chatterji, U.3    Berger, C.4    Snoeck, J.5
  • 51
    • 31644439149 scopus 로고    scopus 로고
    • Insertion and deletion analyses identify regions of non-structural protein 5A of Hepatitis C virus that are dispensable for viral genome replication
    • Liu S, Ansari IH, Das SC, Pattnaik AK, (2006) Insertion and deletion analyses identify regions of non-structural protein 5A of Hepatitis C virus that are dispensable for viral genome replication. J Gen Virol 87: 323-327.
    • (2006) J Gen Virol , vol.87 , pp. 323-327
    • Liu, S.1    Ansari, I.H.2    Das, S.C.3    Pattnaik, A.K.4
  • 52
    • 67649197727 scopus 로고    scopus 로고
    • Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles
    • Hughes M, Griffin S, Harris M, (2009) Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles. J Gen Virol 90(Pt 6): 1329-1334.
    • (2009) J Gen Virol , vol.90 , Issue.Pt 6 , pp. 1329-1334
    • Hughes, M.1    Griffin, S.2    Harris, M.3
  • 53
    • 3142764760 scopus 로고    scopus 로고
    • Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes
    • Moradpour D, Evans MJ, Gosert R, Yuan Z, Blum HE, et al. (2004) Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes. J Virol 78: 7400-7409.
    • (2004) J Virol , vol.78 , pp. 7400-7409
    • Moradpour, D.1    Evans, M.J.2    Gosert, R.3    Yuan, Z.4    Blum, H.E.5
  • 54
    • 34247631514 scopus 로고    scopus 로고
    • Analysis of hepatitis C virus superinfection exclusion by using novel fluorochrome gene-tagged viral genomes
    • Schaller T, Appel N, Koutsoudakis G, Kallis S, Lohmann V, et al. (2007) Analysis of hepatitis C virus superinfection exclusion by using novel fluorochrome gene-tagged viral genomes. J Virol 81: 4591-4603.
    • (2007) J Virol , vol.81 , pp. 4591-4603
    • Schaller, T.1    Appel, N.2    Koutsoudakis, G.3    Kallis, S.4    Lohmann, V.5
  • 55
    • 33646743366 scopus 로고    scopus 로고
    • Characterization of the early steps of hepatitis C virus infection by using luciferase reporter viruses
    • Koutsoudakis G, Kaul A, Steinmann E, Kallis S, Lohmann V, et al. (2006) Characterization of the early steps of hepatitis C virus infection by using luciferase reporter viruses. J Virol 80: 5308-5320.
    • (2006) J Virol , vol.80 , pp. 5308-5320
    • Koutsoudakis, G.1    Kaul, A.2    Steinmann, E.3    Kallis, S.4    Lohmann, V.5
  • 56
    • 34548316984 scopus 로고    scopus 로고
    • The lipid droplet is an important organelle for hepatitis C virus production
    • Miyanari Y, Atsuzawa K, Usuda N, Watashi K, Hishiki T, et al. (2007) The lipid droplet is an important organelle for hepatitis C virus production. Nat Cell Biol 9: 1089-1097.
    • (2007) Nat Cell Biol , vol.9 , pp. 1089-1097
    • Miyanari, Y.1    Atsuzawa, K.2    Usuda, N.3    Watashi, K.4    Hishiki, T.5
  • 57
    • 44949107514 scopus 로고    scopus 로고
    • Critical role of virion-associated cholesterol and sphingolipid in hepatitis C virus infection
    • Aizaki H, Morikawa K, Fukasawa M, Hara H, Inoue Y, et al. (2008) Critical role of virion-associated cholesterol and sphingolipid in hepatitis C virus infection. J Virol 82: 5715-5724.
    • (2008) J Virol , vol.82 , pp. 5715-5724
    • Aizaki, H.1    Morikawa, K.2    Fukasawa, M.3    Hara, H.4    Inoue, Y.5
  • 58
    • 34548316984 scopus 로고    scopus 로고
    • The lipid droplet is an important organelle for hepatitis C virus production
    • 089-1097
    • MiyanariY, Atsuzawa K, Usuda N, Watashi K, Hishiki T, et al. (2007) The lipid droplet is an important organelle for hepatitis C virus production. Nat. Cell Biol 9:1 089-1097.
    • (2007) Nat. Cell Biol , vol.9 , pp. 1
    • Miyanari, Y.1    Atsuzawa, K.2    Usuda, N.3    Watashi, K.4    Hishiki, T.5
  • 59
    • 42949130180 scopus 로고    scopus 로고
    • Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly
    • Appel N, Zayas M, Miller S, Krijnse-Locker J, Schaller T, et al. (2008) Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly. PLoS Pathog. 4: e1000035.
    • (2008) PLoS Pathog , vol.4
    • Appel, N.1    Zayas, M.2    Miller, S.3    Krijnse-Locker, J.4    Schaller, T.5
  • 60
    • 0028096675 scopus 로고
    • Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome
    • Kaneko T, Tanji Y, Satoh S, Hijikata M, Asabe S, et al. (1994) Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome. Biochem Biophys Res Commun 205: 320-326.
    • (1994) Biochem Biophys Res Commun , vol.205 , pp. 320-326
    • Kaneko, T.1    Tanji, Y.2    Satoh, S.3    Hijikata, M.4    Asabe, S.5
  • 61
    • 0028978937 scopus 로고
    • Phosphorylation of hepatitis C virusencoded nonstructural protein NS5A
    • Tanji Y, Kaneko T, Satoh S, Shimotohno K, (1995) Phosphorylation of hepatitis C virusencoded nonstructural protein NS5A. J Virol 69: 3980-3986.
    • (1995) J Virol , vol.69 , pp. 3980-3986
    • Tanji, Y.1    Kaneko, T.2    Satoh, S.3    Shimotohno, K.4
  • 62
    • 8644290077 scopus 로고    scopus 로고
    • Reduction of Hepatitis C Virus NS5A Hyperphosphorylation by Selective Inhibition of Cellular Kinases Activates Viral RNA Replication in Cell Culture
    • Neddermann P, Quintavalle M, Di Pietro C, Clementi A, Cerretani C, et al. (2004) Reduction of Hepatitis C Virus NS5A Hyperphosphorylation by Selective Inhibition of Cellular Kinases Activates Viral RNA Replication in Cell Culture. J Virol 78: 13306-13314.
    • (2004) J Virol , vol.78 , pp. 13306-13314
    • Neddermann, P.1    Quintavalle, M.2    Di Pietro, C.3    Clementi, A.4    Cerretani, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.