Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 19, 2012, Pages 5864-5883

  Ikuma, Yohei ^a   Hochigai, Hitoshi ^a   Kimura, Hidenori ^a   Nunami, Noriko ^a   Kobayashi, Tomonori ^a   Uchiyama, Katsuya ^a   Furuta, Yudai ^a   Sakai, Mutsuko ^a   Horiguchi, Masakuni ^a   Masui, Yumi ^a   Okazaki, Kazuhiko ^a   Sato, Yasuhiro ^a   Nakahira, Hiroyuki ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

3H Imidazo 4,5 c quinolin 4(5H) one; Dipeptidyl peptidase IV; Lys554; Type 2 diabetes

Indexed keywords

2 (3 AMINOPIPERIDIN 1 YL) 3 (2 CHLORO 5 FLUOROBENZYL) 5 METHYL 4 OXO 4,5 DIHYDRO 3H IMIDAZO[4,5 C]QUINOLINE 7 CARBOXYLIC ACID; 2 (3 AMINOPIPERIDIN 1 YL) 3 (2 CHLOROBENZYL) 5 METHYL 4 OXO 4,5 DIHYDRO 3H IMIDAZO[4,5 C]QUINOLIN 6 CARBOXYLIC ACID; 2 (3 AMINOPIPERIDIN 1 YL) 3 (2 CHLOROBENZYL) 5 METHYL 4 OXO 4,5 DIHYDRO 3H IMIDAZO[4,5 C]QUINOLIN 8 CARBOXAMIDE; 2 (3 AMINOPIPERIDIN 1 YL) 3 (2 CHLOROBENZYL) 5 METHYL 4 OXO 4,5 DIHYDRO 3H IMIDAZO[4,5 C]QUINOLINE 8 CARBOXYLIC ACID; 2 (3 AMINOPIPERIDIN 1 YL) 3 (2 CHLOROBENZYL) 8 (DIFLUOROMETHOXY) 5 METHYL 3,5 DIHYDRO 4H IMIDAZO[4,5 C]QUINOLIN 4 ONE; 2 [3 [(TERT BUTOXYCARBONYL)AMINO]PIPERIDIN 1 YL] 3 (2 CHLOROBENZYL) 5 METHYL 4 OXO 4,5 DIHYDRO 3H IMIDAZO[4,5 C]QUINOLINE 8 CARBOXYLIC ACID; 3H IMIDAZO[4,5 C]QUINOLIN 4(5H) ONE DERIVATIVE; ALOGLIPTIN; CARBOXYL GROUP; DIPEPTIDYL PEPTIDASE; DIPEPTIDYL PEPTIDASE II; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; DIPEPTIDYL PEPTIDASE IX; DIPEPTIDYL PEPTIDASE VIII; LINAGLIPTIN; LYSINE; METHYL 2 (3 AMINOPIPERIDIN 1YL) 3 (2 CHLOROBENZYL) 5 METHYL 4 OXO 4,5 DIHYDRO 3H IMIDAZO[4,5 C]QUINOLINE 8 CARBOXYLATE; METHYL 2 [3 [(TERT BUTOXYCARBONYL)AMINO]PIPERIDIN 1 YL] 3 (2 CHLOROBENZYL) 5 METHYL 4 OXO 4,5 DIHYDRO 3H IMIDAZO[4,5 C]QUINOLINE 8 CARBOXYLATE; METHYL 4 [[[2 [3 [(TERT BUTOXYCARBONYL)AMINO]PIPERIDIN 1 YL] 1 (2 CHLOROBENZYL) 4 IODO 1H IMIDAZOL 5 YL]CARBONYL]AMINO]BENZOATE; METHYL 4 [[[2 [3 [(TERT BUTOXYCARBONYL)AMINO]PIPERIDIN 1 YL] 1 (2 CHLOROBENZYL) 4 IODO 1H IMIDAZOL 5 YL]CARBONYL]METHYLAMINO]BENZOATE; PALLADIUM; POTASSIUM CHANNEL HERG; QUINOLINE DERIVATIVE; SAXAGLIPTIN; SEPRASE; SITAGLIPTIN; TERT BUTYL [1 [8 CARBAMOYL 3 (2 CHLOROBENZYL) 5 METHYL 4 OXO 4,5 DIHYDRO 3H IMIDAZO[4,5 C]QUINOLIN 2 YL]PIPERIDIN 3 YL]CARBAMATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VILDAGLIPTIN;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHANNEL GATING; CROSS COUPLING REACTION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; INFRARED SPECTROSCOPY; LIPIDOSIS; MOLECULAR DOCKING; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTON NUCLEAR MAGNETIC RESONANCE; THIN LAYER CHROMATOGRAPHY;

DIABETES MELLITUS, TYPE 2; DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; HUMANS; IMIDAZOLES; MOLECULAR DOCKING SIMULATION; QUINOLINES;

EID: 84866424769     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.07.046     Document Type: Article

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