Phosphoramidate derivatives of acyclovir: Synthesis and antiviral activity in HIV-1 and HSV-1 models in vitro

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 19, 2012, Pages 5802-5809

  Zakirova, Natalia F ^a   Shipitsyn, Alexander V ^a   Jasko, Maxim V ^a   Prokofjeva, Maria M ^a   Andronova, Valeria L ^b   Galegov, Georgiy A ^b   Prassolov, Vladimir S ^a   Kochetkov, Sergey N ^a  

^a ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^b D I IVANOVSKY INSTITUTE OF VIROLOGY   (Russian Federation)

Author keywords

Acyclovir (ACV); Antiviral activity; Herpes Simplex Virus (HSV); Human Immunodeficiency Virus (HIV); Phosphoramidates

Indexed keywords

9 (2 HYDROXYETHOXYMETHYL)GUANINE PHOSPHORODIAMIDATE; 9 (2 HYDROXYETHOXYMETHYL)GUANINE PHOSPHORODIHEXYLAMIDATE; 9 (2 HYDROXYETHOXYMETHYL)GUANINE PHOSPHORODIMORPHOLIDATE; 9 (2 HYDROXYETHOXYMETHYL)GUANINE PHOSPHORODIPYRROLIDATE; 9 (2 HYDROXYETHOXYMETHYL)GUANINE PHOSPHOROMONO 3 DIMETHYLAMINO 1 PROPYLAMIDATE; 9 (2 HYDROXYETHOXYMETHYL)GUANINE PHOSPHOROMONO N MORPHOLINOETHYLAMIDATE; 9 (2 HYDROXYETHOXYMETHYL)GUANINE PHOSPHOROMONO N,N DIMETHYLAMINOETHYLAMIDATE; 9 (2 HYDROXYETHOXYMETHYL)GUANINE PHOSPHOROMONODIPROPYLAMIDATE; 9 (2 HYDROXYETHOXYMETHYL)GUANINE PHOSPHOROMONOHEXYLAMIDATE; 9 (2 HYDROXYETHOXYMETHYL)GUANINE PHOSPHOROMONOMORPHOLIDATE; 9 (2 HYDROXYETHOXYMETHYL)GUANINE PHOSPHOROMONOPYRROLIDATE; 9 (2 HYDROXYMETHYL)GUANINE PHOSPHOROMONOMORPHOLIDATE; ACICLOVIR DERIVATIVE; ANTIVIRUS AGENT; PHOSPHORAMIDIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ARTICLE; DRUG CYTOTOXICITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; NONHUMAN; PH; VIRUS INHIBITION; VIRUS PARTICLE; VIRUS REPLICATION; VIRUS STRAIN; WILD TYPE;

ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; HEK293 CELLS; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HIV INFECTIONS; HIV-1; HUMANS; VERO CELLS; VIRUS REPLICATION;

HUMAN HERPESVIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; SIMPLEXVIRUS;

EID: 84866423253     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.08.008     Document Type: Article

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