Antiherpetic properties of acyclovir 5′-hydrogenphosphonate and the mutation analysis of herpes virus resistant strains

Chemical Biology and Drug Design

Volumn 74, Issue 4, 2009, Pages 382-389

  Gus'Kova, Anna A ^a   Skoblov, Mikhail Yu ^a   Korovina, Anna N ^b   Yasko, Maxim V ^b   Karpenko, Inna L ^b   Kukhanova, Marina K ^b   Andronova, Valeria L ^c   Galegov, George A ^c   Skoblov, Yuri S ^d  

^a RESEARCH CENTRE FOR MEDICAL GENETICS   (Russian Federation)

^b ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^c D I IVANOVSKY INSTITUTE OF VIROLOGY   (Russian Federation)

^d SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

Author keywords

5 hydrogenphosphonate; Herpes simplex virus; Inhibitors; Mutations; Resistance

Indexed keywords

ACICLOVIR; ACICLOVIR 5' HYDROGENPHOSPHONATE; ACICLOVIR DERIVATIVE; DNA POLYMERASE; THYMIDINE KINASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ANTIVIRAL SUSCEPTIBILITY; ANTIVIRAL THERAPY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CROSS RESISTANCE; DOSE RESPONSE; DRUG SAFETY; ENZYME ACTIVITY; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; MALE; MOLECULAR CLONING; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; TREATMENT OUTCOME; VERO CELL; VIRUS MUTATION; VIRUS REPLICATION; VIRUS STRAIN;

ACYCLOVIR; AMINO ACID SEQUENCE; ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; DRUG RESISTANCE, VIRAL; HERPESVIRIDAE; HERPESVIRIDAE INFECTIONS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MUTATION; SEQUENCE ALIGNMENT; THYMIDINE KINASE; VERO CELLS;

ANIMALIA; HERPESVIRIDAE; HUMAN HERPESVIRUS 1; MUS; SIMPLEXVIRUS;

EID: 70349135966     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2009.00874.x     Document Type: Article

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