Extensive rigid analogue design maps the binding conformation of potent N -benzylphenethylamine 5-HT2A serotonin receptor agonist ligands

ACS Chemical Neuroscience

Volumn 4, Issue 1, 2013, Pages 96-109

  Juncosa, Jose I ^a   Hansen, Martin ^a   Bonner, Lisa A ^a   Cueva, Juan Pablo ^a   Maglathlin, Rebecca ^a   McCorvy, John D ^a   Marona Lewicka, Danuta ^a   Lill, Markus A ^a   Nichols, David E ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

5 HT2A; agonist; hallucinogen; molecular model; rigid analogue; serotonin

Indexed keywords

2 (4 BROMO 2,5 DIMETHOXYBENZYL) 6 (2 METHOXYPHENYL)PIPERIDINE; 2 (4 BROMO 2,5 DIMETHOXYPHENETHYL) 1,2,3,4 TETRAHYDROISOQUINOLINIUM CHLORIDE; 3 (2,5 DIMETHOXY 4 BROMOBENZYL) 1,2,3,4 TETRAHYDROISOQUINOLINIUM; 3 (4 BROMO 2,5 DIMETHOXYPHENYL) 1 (2 METHOXYBENZYL)PIPERIDINE; 4 (4 BROMO 2,5 DIMETHOXYPHENYL) 1,2,3,4 TETRAHYDROISOQUINOLINIUM; 4 (4 BROMO 2,5 DIMETHOXYPHENYL) 2,3,4,5 TETRAHYDRO 1H BENZ[C]AZEPINE; 5 (4 BROMO 2,5 DIMETHOXYPHENYL) 2 (2 METHOXYPHENYL)PIPERIDINE; BENZAZEPINE DERIVATIVE; CINANSERIN; MIANSERIN; N BENZYLPHENETHYLAMINE DERIVATIVE; PIPERIDINE DERIVATIVE; SEROTONIN 2A AGONIST; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING SITE; DRUG CONFORMATION; DRUG DESIGN; DRUG DISCRIMINATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; IN VIVO STUDY; LIGAND BINDING; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; RAT;

AFFINITY LABELS; BENZAZEPINES; HALLUCINOGENS; HUMANS; LIGANDS; MODELS, MOLECULAR; PHENETHYLAMINES; PROTEIN CONFORMATION; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN 5-HT2 RECEPTOR AGONISTS;

EID: 84866414310     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn3000668     Document Type: Article

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