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Analytical Chemistry

Volumn 84, Issue 18, 2012, Pages 8045-8051

Evaluation of intact mass spectrometry for the quantitative analysis of protein therapeutics

(2) Gucinski, Ashley C a Boyne, Michael T a

a CENTER FOR DRUG EVALUATION AND RESEARCH (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSOLUTE INTENSITY; ANALYTES; ANALYTICAL TECHNIQUES; CHARGE STATE; CHEMICAL FINGERPRINT; COMPARATIVE METHODS; DEGRADATION PRODUCTS; INTACT PROTEINS; INTERNAL STANDARDS; MANUFACTURING PROCESS; MODEL SYSTEM; MODIFIED PROTEINS; MULTIPLE CHARGE; PEPTIDE MAPPING; POST-TRANSLATIONAL MODIFICATIONS; PROTEIN SPECIES; PROTEIN THERAPEUTICS; QUALITY ASSESSMENT; RELATIVE RATIOS; STANDARD CURVES; STORAGE CONDITION; THERAPEUTIC DRUGS;

BYPRODUCTS; CHEMICAL MODIFICATION; DEGRADATION; ISOTOPES; MASS SPECTROMETRY;

PROTEINS;

DRUG; INSULIN; PEPTIDE; PROTEIN;

ARTICLE; ELECTROSPRAY MASS SPECTROMETRY; EVALUATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PEPTIDE MAPPING; PROTEIN PROCESSING;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INSULIN; PEPTIDE MAPPING; PEPTIDES; PHARMACEUTICAL PREPARATIONS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84866414226 PISSN: 00032700 EISSN: 15206882 Source Type: Journal
DOI: 10.1021/ac301949j Document Type: Article

Times cited : (38)

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