Detection of protein modifications and counterfeit protein pharmaceuticals using isotope tags for relative and absolute quantification and matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry: Studies of insulins

Analytical Biochemistry

Volumn 379, Issue 2, 2008, Pages 182-191

  Ye, Hongping ^a   Hill, John ^a   Kauffman, John ^a   Gryniewicz, Connie ^a   Han, Xianlin ^b  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aggregation; Counterfeit; Deamidation; Generic protein drugs; Glu C; Insulins; iTRAQ MALDI

Indexed keywords

AGGLOMERATION; CRIME; DESALINATION; DESORPTION; DRUG PRODUCTS; INSULIN; ISOTOPES; MAMMALS; MASS SPECTROMETERS; PROTEINS; REAGENTS;

ACTIVE PHARMACEUTICAL INGREDIENTS; COUNTERFEIT; DEAMIDATION; ITRAQ/MALDI; MASS SPECTROMETRIC ANALYSIS; MATRIX ASSISTED LASER DESORPTION/IONIZATION; PROTEIN DRUGS; TIME OF FLIGHT MASS SPECTROMETRY;

MASS SPECTROMETRY;

BOVINE INSULIN; HUMAN INSULIN; INSULIN GLARGINE; INSULIN LISPRO; ISOPHANE INSULIN; PIG INSULIN; REAGENT; RECOMBINANT DNA;

AMINO ACID SEQUENCE; ARTICLE; DRUG DETERMINATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN MODIFICATION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS;

BOVINAE; SUS;

EID: 45849125372     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2008.04.037     Document Type: Article

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